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Author Topic: Shingles Vaccine and Anal Warts Vaccine are in trials and may be approved  (Read 3132 times)

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Offline bimazek

  • Member
  • Posts: 781
Shingles Vaccine and Anal Warts Vaccine are in trials and may be approved

These are two diseases which are very common in hiv poz guys even on haart

and Shingles for example is horribly painful   Shingles= old chicken pox virus popping up again can cause blindness and other terrible complications

Anal Warts = HPV ... think texas with the vaccine of women for cervical cancer
get this vaccine to avoid cancer in anus

get these vaccines when and if they are approved

if you

every had chicken pox  -- you did

and

if you even had passive anal sex




Offline trellium

  • Member
  • Posts: 95
  • stArk raving Borg
hiya

You can ask your doc about getting Gardasil (HPV vaccine) for off-label use since it is not yet clear whether the vaccine is as effective for men as it is for women. (some risks, expensive too)

Are you referring to Zostavax (Shingles vaccine)?
It is actually a boosted dose (14 times more potent) of the Varivax (Merck's chickenpox vaccine) currently given to children and has already been approved by the FDA in 2006.

It is a live vaccine and should be avoided by all pozzies.

http://www.fda.gov/Cber/products/zosmer052506qa.htm
(from Q&A # 8  )

Who should not be immunized with Zostavax?

People who are allergic to neomycin, or any component of the vaccine should not receive Zostavax. Zostavax is a live vaccine and should not be given to individuals who have a weakened immune system caused by treatments that they are taking such as radiation, a class of drugs called corticosteroids, or due to conditions such as AIDS, cancer of the lymph, bone or blood.

In addition, Zostavax should not be used by women who are or may be pregnant.

Zostavax should not be used in children and it is not a substitute for Varivax, the vaccine to prevent chicken pox.

In addition, people who are in close contact with pregnant women who have not had chickenpox should talk to their healthcare provider to decide if using Zostavax is right for them.

Offline risred1

  • Member
  • Posts: 419
  • My Source for Supps - www.newyorkbuyersclub.org
Some Vaccines or Anti Viral Drugs such Valtrex do come with warnings about those with immune dieseases such as AIDS.

However, HIV impacted folks may still be able to be vaccinated and take Valtrex if your system is still above, "severely impacted", as stated in the Valtrex documentation.

Absolutely work with your HIV specialist, not your general practitioner, unless your GP is really up on HIV.

There is also some research going on about how these anti retroviral vaccines and drugs may infact help the body fight against HIV. I still can't find much information on this though.

 
risred1 - hiv +
02/07 CD4 404 - 27% - VL 15k
10/07 CD4 484 - 31% - VL 45k
05/08 CD4 414 - 26% - VL 70k
01/09 CD4 365 - 23% - VL 65k
05/09 CD4 291 - 23% - VL 115k - Started Meds - Reyataz/Truvada
06/09 CD4 394 - ?% - VL 1200 - Boosted Reyataz with Norvir and Truvada
07/09 CD4 441 - ?% - VL 118 - Boosted Reyataz with Norvir and Truvada
09/09 CD4 375 - ?% - VL Undetectable - Boosted Reyataz with Norvir and Truvada
12/09 CD4 595 - ?% - VL Undetectable - VIT D 34 - Reyataz/Truvada/Norvir

Offline northernguy

  • Member
  • Posts: 1,347
But Gardasil isn't a therapeutic vaccine is it?  So for those of us who already have HPV it won't do any good.
Apr 28/06 cd4 600 vl 10,600 cd% 25
Nov 8/09 cd4 510 vl 49,5000 cd% 16
Jan 16/10 cd4 660 vl 54,309 cd% 16
Feb 17/10 Started Atripla
Mar 7/10 cd4 710 vl 1,076 cd% 21
Apr 18/10 cd4 920 vl 268 cd% 28
Jun 19/10 cd4 450 vl 60 cd% 25
Aug 15/10 cd4 680 vl 205 cd% 27
Apr 3/11 cd4 780 vl <40 cd% 30
Jul 17/11 cd4 960 vl <40 cd%33
April 15/12 cd4 1,010 vl <40 cd% 39
April 20/12 Switched to Viramune + Truvada
Aug 2/12 cd4 1040, vl <40, cd% 38
Oct 19 cd4 1,110 vl <40 cd% 41

Offline hahaha

  • Member
  • Posts: 123
Since my CD4 is above 400, My doc suggest me to have HPV vaccine.  He told me that actually the vaccine do, in a way, suppress HIV as well, and it "might" boost the other therapeutic vaccine in the future. 

Maybe we shall all consult with our docs to see their point of view and exchange the opinion here.
Aug 9, 2006 Get infected in Japan #$%^*
Oct 2006 CD4 239
Nov 2006 CD4 299 VL 60,000
Dec 1, Sustiva, Ziagan and 3TC
Jan 07, CD4 400

Offline NYCguy

  • Member
  • Posts: 180
I don't know anything about the shingles vaccine, although it would seem that if tcell counts were normal it would be ok (however, absolutely check with hiv doc) but I have asked my doc about Guardasil and he gave me a script for it.  It costs about $170 but haven't bought it yet - my brother's ID doc (he's not poz, just gay and up on medical stuff) told him that it might be good to wait a while while they test it in men. 

Also, it is not a theraputic vaccine so it won't help if you already have hpv, however, my doc said it won't hurt you either.  It's still not clear to me if/how you can test for hpv.  Also, there are a number of different strains, so it's possible to have one strain and still benefit from Guardiasil if you don't have one of the four strains (the most cancer causing ones) that it protects against.

I did hear something about how it might have some theraputic effect for hiv...any more info on that appreciated.  I always worry about negative interations with potential future drugs or vaccines...
11/9/06 = #$%^&!
sometime early Dec 2006:
CD4 530 20%/VL >250,000 (&*$$%!!)
started Reyataz300mg/Norvir/Truvada 12-27-06.
1/30/07 CD4 540 30%/VL <400
4/07 CD4 600+ 33%/VL <50
6/9/07 CD4 720 37%/VL <50
10/15/07 CD4 891 (!) %? VL <50
1/2010 CD4 599 (37%) VL<50 (drop due to acute HCV)
9/2010 - looks like HCV is gone for good! And I'm finally drinking again, thank GOD
2013 - considering a switch to Stribild. but I love my Kidneys (but I hate farting all the time!)...
June 2013 - switched to Stribild.  so far so good...

Offline Miss Philicia

  • Member
  • Posts: 24,005
  • celebrity poster, faker & poser
You test for HPV by getting an anal pap smear, or at least that is the first step.  80% of HIV positive gay men already have HPV it is estimated.
"Iíve slept with enough men to know that Iím not gay"

Offline dixieman

  • Member
  • Posts: 889
When their available... I'll be first inline... never had hpv... and I had the pap smear to check for anal cancer..luckily I came back ok... but, who knows what may change in the future...  I have had shingles... 3 times at stressful moments in life... shingles are no fun...

Offline bimazek

  • Member
  • Posts: 781
there are phase trials of Therapeutic HPV vaccines  ... that is why i posted,... even if you have the virus you can get vaccine soon... i hope for approval

In addition to preventive vaccines, such as Gardasil and Cervarix, laboratory research and several human clinical trials are focused on the development of therapeutic HPV vaccines. In general these vaccines focus on the main HPV oncogenes, E6 and E7. Since expression of E6 and E7 is required for promoting the growth of cervical cancer cells (and cells within warts), it is hoped that immune responses against the two oncogenes might eradicate established tumors.[15]
t
http://en.wikipedia.org/wiki/HPV_vaccine

i think it is Authorised Medicines for Human Use - Gardasil
Therapeutic Indication. Gardasil is a vaccine for the prevention of high-grade cervical dysplasia (CIN 2/3), cervical carcinoma, high-grade vulvar ...
www.emea.europa.eu/humandocs/Humans/EPAR/gardasil/gardasil.htm
Roche enters therapeutic vaccines market - MarketWatch


Transgene's lead product, a therapeutic vaccine candidate codenamed TG 4001, differs from Gardasil - a new vaccine made by Sanofi SA (SNY : ...
www.marketwatch.com/.../story.aspx?guid=%7BB7DB4314-C935-4828-9479-CCE819A31EB8%7D

World market for cancer vaccines 2007-2012
Revenue forecasts for Gardasil and Cervarix 2007-2012; Table 4.1. Therapeutic cancer vaccines with licenses or predicted to obtain them within the forecast ...
www.leaddiscovery.co.uk/reports/World_market_for_cancer_vaccines.html - 44k - Cached - Similar pages
Pharm Aid: Dendreon
Well, cancer vaccines are back, driven partly, by approval of Merckís Gardasil. Therapeutic cancer vaccines are making news again. An FDA advisory committee ...
pharm-aid.blogspot.com/search/label/Dendreon


Human Papillomavirus Vaccines: Q & A - National Cancer Institute
NCI is also collaborating with other researchers on therapeutic HPV vaccines that would prevent the development of cancer among women previously exposed to ...
www.cancer.gov/cancertopics/factsheet/risk/HPV-vaccine - 54k - Cached - Similar pages
Aidsmap | An HPV vaccine - what it might really mean
Still, therapeutic HPV vaccines are also being developed to treat established ... If these therapeutic HPV vaccines prove as successful in patients as they ...
www.aidsmap.com/en/news/3429199D-5FE5-4795-B0E6-CD957617C160.asp - 30k - Cached - Similar pages

Biotechnology firms, pharmaceutical companies, and academic researchers are
working to develop vaccines against the types of human papillomavirus (HPV) that
cause most, if not all, cases of cervical cancer. Some are designing prophylactic
vaccines to prevent initial infections with HPV; if successful, these vaccines
ultimately could eliminate the public health problem of cervical cancer. Others are
focusing on therapeutic vaccines to control the progress of established disease or
prevent its recurrence in women who already have cervical dysplasia or cancer.
Vaccine developers face many technical challenges, in part because the HPV virus
itself has evolved various strategies for evading the immune response

Therapeutic HPV vaccines must prompt cell-
mediated immunity in order to be effective, since antibodies cannot reach and
eliminate the virus once it has been incorporated into host cells.


Randomized, double-blind, placebo-controlled Phase IIb trials are
currently taking place in multiple sites in Europe, Canada, Scandinavia, Australia, and
New Zealand.
34
These will assess wart recurrence rates and rates of disease
regression following vaccination.
Building on the success of its peptide vaccine against genital warts, Cantab has begun
developing a similar fusion protein vaccine to treat cervical dysplasia. By treating
early-stage cervical disease, scientists hope to reduce treatment costs and patient
trauma. This vaccine called TA-CIN uses a novel adjuvant (NAX-57) developed by
NovaVax Inc. (Columbia, MD, USA).


A major breakthrough in HPV vaccine research came with the discov-
ery that the capsid proteins L1 and L2 (or L1 alone) self-assemble into
virus-like particles (VLPs) when expressed in cells. VLPs closely
resemble native HPV particles and include the conformational epitopes
that induce virus-neutralizing antibodies. Therefore, the immune system
perceivesb VLPs as infectious viruses and responds accordingly

able 2. Therapeutic HPV Vaccines Under Development*
*Note: While efforts were made to be comprehensive, this is not a com

http://209.85.165.104/search?q=cache:GrODQKx0Pq0J:www.path.org/files/jsrp13710.pdf+%22therapeutic+HPV+vaccines%22&hl=en&ct=clnk&cd=1&gl=us

Table 2. Therapeutic HPV Vaccines Under Development*
*Note: While efforts were made to be comprehensive, this is not a complete list.

 


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