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Author Topic: Gilead knew that Truvada was toxic before 2004...  (Read 121 times)

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Offline Mishma

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Gilead knew that Truvada was toxic before 2004...
« on: Today at 08:51:58 AM »
And had started research on a safer version (TAF) at that time. The company stopped their research and only restarted it because the patent on Truvada is expiring in 2018.

And we're still schlepping Truvada as PrEP. 

http://www.latimes.com/business/la-fi-gilead-20160529-snap-story.html

* For acute infection and for those younger patients or in resource poor locations, Truvada has it's place.

2016 CD4 25% UD (less than 20). 30+ years positive. Dolutegravir, Acyclovir, Clonazepam, Lisinopril, Quetiapine, Sumatriptan/Naproxen, Restasis, Latanoprost, Asprin, Levothyroxine, Restasis, Triamcinolone.

Offline leatherman

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Re: Gilead knew that Truvada was toxic before 2004...
« Reply #1 on: Today at 10:34:53 AM »
truvada simply has a higher toxicity than we would like. I've been taking Viread/Truvada since 2001 with zero side effects - the same as the vast majority of Tenofovir disoproxil users. While I certainly agree that TDF is a much better medication, and that TAF does have it share of negative side effects, let's not throw out the baby with the bathwater. Every HIV medication has it's share of bad side effects for a small amount of the patient population. There are no 100% side effect free meds (of any kind!) on the market. (Aspirin still kills 100s of people a year yet it can be found cheap on store shelves for anyone to purchase - with little notice or worry about it's deadly potential) However, because some people have a negative reaction doesn't mean the med doesn't work fine for a large number of people.

what then would you suggest we "schlep" in place of Truvada? There's never going to be a side effect free drug to offer HIV- people, but if we weren't offering Truvada, right now there would be no PrEP option to offer at all. :(

The research originally stopped because they had developed a medication with a high tolerability rate. No company is ever under a mandate to further improve a medication - although as consumers we certainly would hope that research and refinement would continue. After years of successful Truvada therapy for patients, the company re-visited this medication to improve it further - as other current HIV meds are improvements on previous meds.

whether a decade ago gilead, knowingly with precognition, stopped research on TDF, willfully endangering the life and health of patients, for the sole motive of profits to be made when they developed TDF as a response to the TAF patent expiration is definitely an issue will need be decided by a court.


* For acute infection and for those younger patients or in resource poor locations, Truvada has it's place.
some estimates are that 627,000 of maybe only 850,000 PLWH in America take Tenofovir as part of their HIV regimen, so Truvada already has a place beyond the groups you mentioned.
leatherman (aka mIkIE)

Sometimes it snows in April
Sometimes I feel so bad, so bad
Sometimes I wish that life was never ending,
But all good things, they say, never last

All good things, they say, never last
And love, it isn't love until it's past

chart from 1992-2015
Isentress/Prezcobix

Offline Mishma

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Re: Gilead knew that Truvada was toxic before 2004...
« Reply #2 on: Today at 10:43:33 AM »
Physicians are trained to first and foremost-Do no harm. Truvada has proven toxicities. Condoms, to my knowledge, do not.

And to compare Asprin to Truvada is disingenuous and misses the point.


I will be joining this lawsuit.
2016 CD4 25% UD (less than 20). 30+ years positive. Dolutegravir, Acyclovir, Clonazepam, Lisinopril, Quetiapine, Sumatriptan/Naproxen, Restasis, Latanoprost, Asprin, Levothyroxine, Restasis, Triamcinolone.

Offline Wade

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Re: Gilead knew that Truvada was toxic before 2004...
« Reply #3 on: Today at 10:54:27 AM »
I'm with leatherman on this one .
I've taken Viread since it was approved and have no kidney issues
and my bones were strong enough to take on 2 knee replacements.

Truvada is keeping many from being newly infected and to me the risk is outweighed.
I also don't think there is a drug on the market that is with out side affects.
I took some of the worst of the worst and would do it again ...they saved my life.
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Offline leatherman

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Re: Gilead knew that Truvada was toxic before 2004...
« Reply #4 on: Today at 11:06:05 AM »
Physicians are trained to first and foremost-Do no harm. Truvada has proven toxicities.
what medications are you currently taking? I hope they are doing well for you, keeping you healthy and UD. However, there are people taking those exact same medications having a horrible time with both long and short term effects. Do you plan on filing suit against those companies also?

I will be joining this lawsuit.
that's good. please make sure to keep us up to date on the proceedings. I'm just as anxious to see 1) if gilead did this knowingly; 2) if they did it with malice; 3) if they broke any laws; and 4) how government can in any way force the pharma industry to constantly re-evaluate and update their medications to provide as close to 0 side effects as possible (or "no harm" as you mentioned).
leatherman (aka mIkIE)

Sometimes it snows in April
Sometimes I feel so bad, so bad
Sometimes I wish that life was never ending,
But all good things, they say, never last

All good things, they say, never last
And love, it isn't love until it's past

chart from 1992-2015
Isentress/Prezcobix

Offline Mishma

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  • HIV drugs are our Allies but hardly our Friends
    • Marquis de Vauban
Re: Gilead knew that Truvada was toxic before 2004...
« Reply #5 on: Today at 01:10:09 PM »
Leatherman

I know all this and my remarks were for PrEP, and not for acute infection-as I posted. Two different beasts, yet as the article points out Gilead will be promoting TAF for acute infection-by comparing it favorably over Truvada (and other formulations).

I'm currently on mono therapy with Tivicay and undetectable, but I still struggle with cognition and periodic flairs. Since we don't test reservoirs and rely solely on blood levels and CD4  counts, I'm in a holding pattern until there is enough virus to measure, specifically enough to ascertain whether or not I would be suitable candidate for Selzentry. Believe me I want to add another drug as I too am concerned about resistance.

Mind you the bone density issues really didn't become problematic until I started getting joints replaced and had a tough time healing. Likewise my kidney function tests were all within the purported acceptable limits yet when I stopped the drug, and within 3 weeks, I lost 16 lbs-presumably  the water I was retaining.

The only physician I was seeing that said the nucleotides were toxic was my neurologist. When I stopped both my peripheral as well as autonomic neuropathies improved.
2016 CD4 25% UD (less than 20). 30+ years positive. Dolutegravir, Acyclovir, Clonazepam, Lisinopril, Quetiapine, Sumatriptan/Naproxen, Restasis, Latanoprost, Asprin, Levothyroxine, Restasis, Triamcinolone.

 


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