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Author Topic: New class of HIV drug attacks previously untargeted enzyme  (Read 1109 times)

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Offline SASA39

  • Member
  • Posts: 690
New class of HIV drug attacks previously untargeted enzyme
« on: April 13, 2007, 06:08:23 PM »
http://www.eatg.org/news/newsitem.php?id=1493

New class of HIV drug attacks previously untargeted enzyme
Friday, April 13, 2007
 
 
 A new class of anti-HIV drug which inhibits an as-yet untargeted enzyme in the virus has proven effective in a drug trial.

A new class of anti-HIV drug which inhibits an as-yet untargeted enzyme in the virus has proven effective in a drug trial, according to an Article in this week's edition of The Lancet.

There is an urgent need for new antiretroviral drugs due to existing rates of failure in existing combination antiretroviral therapies. The current study looked at the new "integrase- inhibitor" raltegravir when used in conjunction with optimised background combination therapies, in patients with advanced HIV infection whose existing treatments were failing.

There are three types of enzyme essential to the successful replication of HIV-reverse- transcriptase, protease and integrase. Integrase is responsible for insertion of HIV DNA into the host cell's DNA. Until now all antiretroviral drugs for HIV which target enzymes have been reverse-transcriptase or protease inhibitors.

Dr Bach-Yen Nguyen, Merck Research Laboratories, Westpoint, Pennsylvania, USA, and colleagues divided their patients into four groups. One group received the background treatment plus placebo only, and the other three received the background treatment plus 200, 400 or 600 mg of raltegravir twice daily. All 178 patients across the four groups had been receiving antiretroviral therapy for an average of just under 10 years.

The researchers measured the amount of HIV genetic material (HIV RNA) in the blood of patients after 24 weeks, and found that patients taking raltegravir experienced an average of 98% drop in their HIV RNA count, compared to just 45% drop in the placebo group.

The number of CD4 cells-which give an indication of the immune response-were also significantly boosted in patients taking raltegravir. Patients receiving the 400 mg and 600 mg doses increased their CD4 count by 113 and 94 cells per ml of blood respectively.

Raltegravir also proved safe, well tolerated and potent in most of the patients.

In related studies of raltegravir*, 60% of the patients taking the drug reduced their HIV RNA loads to below 50 copies per ml-the lowest recordable value. Only 30% of patients in the placebo group achieved this

The authors conclude: "Taken together with the results of raltegravir in another study, these data confirm that HIV-1 Integrase is a valid target for antiretroviral therapy."

They add: "The promising efficacy and tolerability profile of raltegravir suggest that this drug has the potential to become an important component of combination treatment regimens used to treat heavily pretreated patients failing current therapies with multidrug-resistant virus and limited treatment options."

In an accompanying Comment, Dr Pedro Cahn and Dr Omar Sued, of the Fundación Huesped, Buenos Aires, Argentina, said that a new era of antiretroviral therapy had arrived and AIDS-related illness and deaths would be expected to continue to drop.

But they added: "Unfortunately, for more than 85% of patients living with HIV/AIDS [worldwide], access to basic care, including first-line antiretrovirals, is still unachievable. Will the new generation antiretrovirals help to bridge this gap, or will these extraordinary scientific achievements make the current differences even more painful?"

SOURCE: Medical News TODAY
http://www.medicalnewstoday.com/medicalnews.php?newsid=67577
Oct.     `06.  CD4=58  ?    %       VL not perform. ?!?
25.Dec.`06.         203       14        VL= 0
29.May.`07.    broken device        VL=1363
20.June`07     broken device        VL=0
25.Dec `07  CD4=582                  VL=70
14.May `08  CD4=448
29.July `08                                  VL=0
26.Nov `08  CD4=674                    VL=179
16.Mar `09  CD4=554                    VL=0
19.Jan`10 CD4=715               
03.Mar`10                                    VL=0
24.Aug`10 CD4=524                     VL=0
04.Dec`10 CD4=626                     VL=0
15.Sep`11                                   VL=93
17.Nov`11                                   VL=0
05/26 .Jul`12 CD4=713                 VL=0
28.Nov`12 CD4=916                     VL=0
09.May`13                                 VL=0

 


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