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Author Topic: ABIVAX Phase 2a Trial Treats First Patient  (Read 570 times)

libvet and 1 Guest are viewing this topic.

Offline Jmarksto

  • Member
  • Posts: 544
ABIVAX Phase 2a Trial Treats First Patient
« on: February 02, 2015, 02:17:37 PM »
ABIVAX, a leading clinical stage biotech company developing and commercialising anti-viral compounds and human vaccines, today announced that enrolment has been initiated and the first HIV positive patient dosed in a Phase IIa clinical trial of ABX464.
ABX464 is a novel, small molecule inhibiting HIV replication through an entirely new mechanism. For the first time in the treatment of AIDS, this molecule could deliver a long lasting reduction of the viral load after a treatment of only a few weeks.

http://tinyurl.com/ly9fcq2

« Last Edit: February 02, 2015, 02:26:20 PM by Jmarksto »
03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45%  VL 25
02/25/14 CD4   792/37%  VL UD
07/09/14 CD4 1004/39%   VL UD
11/03/14 CD4   711/34%   VL UD

Offline Matts

  • Member
  • Posts: 239
Re: ABIVAX Phase 2a Trial Treats First Patient
« Reply #1 on: February 02, 2015, 03:22:14 PM »
http://www.abivax.com/en/treatment-of-the-first-hiv-positive-patient-in-abivaxs-phase-iia-clinical-trial-with-abx464/

I read this story today too.
This splicing inhibitor is an interesting new drug class. Resistance seems to be impossible or HIV has to die. Taking the drug only few times a year :)
triumeq

Offline Matts

  • Member
  • Posts: 239
Re: ABIVAX Phase 2a Trial Treats First Patient
« Reply #2 on: Yesterday at 02:43:39 PM »
CROI: "Durable Control of Viral Rebound in Humanized Mice by ABX464 Targeting Rev Functions"

http://www.croiconference.org/sessions/durable-control-viral-rebound-humanized-mice-abx464-targeting-rev-functions

I think that the French invented a pretty interesting stuff. Suppressing VL up to 2 months with a single pill. Monotherapy and completely new dosing schedules could become reality in some years. Maybe :)
triumeq

 


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