Calimmune: Safety Study of a Dual Anti-HIV Gene Transfer Construct to Treat HIV-

[Tadeys]

I remember reading on this forum a couple of months ago how scientist have discovered that they could DIRECTLY engraft cells with zinc fingers--- meaning, pour zinc fingers over cells. The cells studied endocytized the zinc fingers. This lead to a higher engrafment percentage then using the freaking adenovirus vector. But don't know if Callimine's technology can allow that "pouring"; besides, Calimunne is trying to delete a gene---like Sangamo-- AND insert an anti HIV gene....so, I think they need a the damn vector.

 There is Proof-of-principle that these anti HIV techniques CAN work...scientist just have to tweak them. Some newer anti HIV gene therapy technologies--still preclinical--seem light years ahead of the technology Sangamo, CoH, or Callimune have.

[geobee]

Carlos Barbas et al are doing "naked" ZFNs at the Scripps Institute in San Diego.  No vector.

http://www.genengnews.com/gen-news-highlights/naked-zfns-point-to-more-efficient-safer-gene-therapy/81246989/

[Hoyland]

For those interested Calimmune's CEO and CSO will be giving a talk on Thursday at noon explaining their work with stem cells and HIV. The talk will be webcast.

http://www.cirm.ca.gov/agendas/05202013/spotlight-hiv-immunity-pathway-clinical-trial?utm_source=twitterfeed&utm_medium=twitter

[JazJon]

For those interested Calimmune's CEO and CSO will be giving a talk on Thursday at noon explaining their work with stem cells and HIV. The talk will be webcast.

http://www.cirm.ca.gov/agendas/05202013/spotlight-hiv-immunity-pathway-clinical-trial?utm_source=twitterfeed&utm_medium=twitter

Interesting, I hope we can listen to it later in the day if we miss the live stream.

[JazJon]

For those interested Calimmune's CEO and CSO will be giving a talk on Thursday at noon explaining their work with stem cells and HIV. The talk will be webcast.

http://www.cirm.ca.gov/agendas/05202013/spotlight-hiv-immunity-pathway-clinical-trial?utm_source=twitterfeed&utm_medium=twitter

I missed it, I don't see any replay streaming options.   Did anyone catch it?  Did they share any interesting new information?

[Jmarksto]

I missed it, I don't see any replay streaming options.   Did anyone catch it?  Did they share any interesting new information?

Jaz; it is scheduled for Thursday (if I read Hoyl's post correctly), and it is still Wednesday so I don't think you have missed it.

[JazJon]

Jaz; it is scheduled for Thursday (if I read Hoyl's post correctly), and it is still Wednesday so I don't think you have missed it.

Oh whoops! lol

[Tadeys]

Can't see the presentation vía my f$&/@ing iPad. Can somebody comment on the presentation. Thanks.

[JazJon]

Well if they said anything interesting, it must have been in the beginning.   

I missed the first 30 minutes.   When I finally joined in, I only heard them voting down funding some unrelated bone stimulation thing.  (and then they broke for lunch)   

I tried again much later and all I heard was several good bye speeches to someone moving on.

So yeah someone will have to fill us in if anything interesting was talked about related to the Calimmune Study specifically.

[Hoyland]

The technology conspired against me and I too missed the presentation. However, the CIRM is shortly going to post a video online and so those that want to see the whole thing will be able to do so.

[Hoyland]

Hi SFGMOMO,

Based on your last post you should have had your second apheresis by now and possibly your treatment. How are things progressing, or have you had to sign a non-disclosure agreement and so are not in a position to tell us?