Welcome, Guest. Please login or register.
December 10, 2016, 06:25:24 AM

Login with username, password and session length

  • Total Posts: 704731
  • Total Topics: 56108
  • Online Today: 271
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 AM)
Users Online
Users: 3
Guests: 111
Total: 114


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Kaletra/Invirase to Prezista (update)  (Read 1905 times)

0 Members and 1 Guest are viewing this topic.

Offline MSPspud

  • Member
  • Posts: 613
  • Joined Mar 2005 - Formerly UofMurbs
Kaletra/Invirase to Prezista (update)
« on: April 04, 2007, 06:35:24 PM »
About two and a half months ago I switched to Prezista from a Kaletra/Invirase combination, all while remaining undetectable.  Since then Iíve gained close to 10 pounds, but to my surprise it hasnít been a bad weight.  Iím starting to build a lot of muscle and have notably been able to lift more than ever before.  Itís like my muscles are on steroids or something Ė even my shoulders are broadening!
When I started Kaletra/Invirase a year and a half before, I remember feeling as if my muscles stopped responding to workouts.  I started going to the gym more frequently to compensate and that seemed to work Ė or at least stopped the weight gain.  I almost forgot about those feelings until this switch.  Now Iím fairly confident my old combo retarded my muscle growth.

I know a few people out there have switched to Prezista.  Have you noticed any changes in your bodyís performance?  Or for those who are on Kaletra/Invirase have you ever noticed your muscles being less responsive to exercise?  I am curious as to any other experiences out there.  I canít wait to bring this up to my doctor in a couple of weeks!


Offline aztecan

  • Member
  • Posts: 5,512
  • 31 years positive, 59 years a pain in the butt
Re: Kaletra/Invirase to Prezista (update)
« Reply #1 on: April 05, 2007, 07:54:27 PM »
Hey Jason,

What are you taking with the Prezista? I presume it is boosted with Norvr.

I am looking at alternatives to see what I might like to switch to. This sounds encouraging if it works for me like it does for you.


"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline RAB

  • Member
  • Posts: 1,895
  • Joined March 2003
Re: Kaletra/Invirase to Prezista (update)
« Reply #2 on: April 05, 2007, 08:04:49 PM »
Hey Spud

I'm taking Kaletra/Invarase and work out regularly.  It's been a long time since I've realized any significant muscle gain (although to be honest, I probably need to be more attentive to changing my routine and could certainly benefit from a trainer--then there's the issue of my age   ::)).   In fact the only time I actually gain muscle mass is when I use steroids (lordy!   ;D), but that gain is usually short lived.

So I'll be very curious to hear what your doctor has to say about this, or whether other members, who've made the switch, have similar experiences.

You think there's something metabolic with the Kaletra/Invarase that is different from the Prezista?


Offline MSPspud

  • Member
  • Posts: 613
  • Joined Mar 2005 - Formerly UofMurbs
Re: Kaletra/Invirase to Prezista (update)
« Reply #3 on: April 06, 2007, 11:43:33 AM »
What are you taking with the Prezista? I presume it is boosted with Norvr.

Yes, it is boosted with Norvir as with most other PI's.  I am also on Epzicom.

You think there's something metabolic with the Kaletra/Invarase that is different from the Prezista?

I am not sure what may be happening but I have a few theories.  Here they are:

1.  I'm sleeping much better, so perhaps my body is able to build more muscle with a more productive sleep.

2.  Perhaps the synergy of Kaletra and Invirase didn't mix with my body's digestion, inhibiting some of protein breakdown and absorption (there are beneficial dietary proteases, BTW).

3.  Maybe Prezista has a molecular structure which is better able to stop HIV replication in the nads, increasing my testosterone.  (I have yet to see studies regarding its ability to cross the blood brain barrier and alike)

4.  I do feel less drugged overall, so perhaps it's all psychological and my mind is pushing my muslces harder while working out.  (Though, I didn't forsee this change when I did the switch). 

So, yes...  it'll be interesting to see what the doc has to say.  He did do some of the initial trials for this drug, so I'm sure he's heard it all.  I will keep you both updated (and anyone else who's interested).
« Last Edit: April 06, 2007, 02:00:38 PM by MSPspud »


Terms of Membership for these forums

© 2016 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.