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Author Topic: Antigen p24 - 4th generation tests  (Read 1525 times)

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Offline blondbeauty

  • Member
  • Posts: 1,785
Antigen p24 - 4th generation tests
« on: June 21, 2006, 02:58:13 PM »
In the subforum "Am I infected" there is a thread titled "4th generation tests". If I understood correctly, antigen p24 dissapears when our bodies seroconvert and create antibodies against HIV. Then...¿why did my antigen p24 test gave a result of 23 (considering a count below 0,25 as negative) If I was already HIV+ in my elisa test?
Can somebody explain this?
Am I in a very advanced stage of the infection if antigen p24 and antibodies are present at the same time?  ???
The only member in these forums approved by WINBA: World International Nail and Beauty Association.
Epstein Barr +; CMV +; Toxoplasmosis +; HIV-1 +.
Counts when starting treatment:
V.L.:80.200 copies. CD4: 25%=503
Started Sustiva-Truvada 14/August/2006
Last V.L.count (Oct 2013): Undetectable
Last CD4 count (OCT 2013): 52%= 933

Offline newt

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  • Posts: 3,869
  • the one and original newt
Re: Antigen p24 - 4th generation tests
« Reply #1 on: June 21, 2006, 05:48:27 PM »
Well disappear is not quite true, it often becomes hard to detect. Since it is not a quantitative test, and has not been related to any stage of HIV infection other than acute infection before antibody production, all the results say are "yes/no, p24 is/isn't present".  That's all.  A fair proportion of people who are HIV antibody-positive will test "yes" on a p24 test from time to time, but clinically speaking, no-one really knows what detectable p24 after seroconversion means, if anything.

See HIV Viral Antigen Assays on HIV InSite for some science:

"When antibodies to HIV become detectable, however, p24 antigen is often no longer demonstrable, most likely due to antigen-antibody complexing in the blood. When detected, p24 antigen is highly specific for infection." (my bold)

- matt
« Last Edit: June 22, 2006, 03:34:10 AM by newt »
"The object is to be a well patient, not a good patient"

Offline blondbeauty

  • Member
  • Posts: 1,785
Re: Antigen p24 - 4th generation tests
« Reply #2 on: June 21, 2006, 06:59:29 PM »
Thank you Matt!
The only member in these forums approved by WINBA: World International Nail and Beauty Association.
Epstein Barr +; CMV +; Toxoplasmosis +; HIV-1 +.
Counts when starting treatment:
V.L.:80.200 copies. CD4: 25%=503
Started Sustiva-Truvada 14/August/2006
Last V.L.count (Oct 2013): Undetectable
Last CD4 count (OCT 2013): 52%= 933

 


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