someone has seen this article?

[brazilianman]

someone has the signature of nature?


A synthetic CD4–heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry
Françoise Baleux1, Latino Loureiro-Morais2, Yael Hersant2, Pascal Clayette3, Fernando Arenzana-Seisdedos4, David Bonnaffé2 & Hugues Lortat-Jacob5



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AbstractThe HIV-1 envelope, gp120, which features the binding determinants for both CD4 and coreceptor recognition, is key for virus entry and represents an attractive pharmacological target. However, critical domains for entry (coreceptor and CD4 binding sites) are either cryptic or located in partially occluded cavities. Here we developed a chemical approach to synthesize a CD4-mimetic peptide linked to a heparan sulfate dodecasaccharide. This molecule binds to gp120, induces the exposure of the coreceptor binding domain and renders it available for interaction with the oligosaccharide. The linkage between the CD4 mimetic and the heparan sulfate derivative provides strong cooperative effects, resulting in low-nanomolar antiviral activity toward both CCR5- and CXCR4-tropic HIV-1 strains. This compound, which has the unique ability to simultaneously target two critical and highly conserved regions of gp120, establishes a new type of inhibitor and suggests a general concept for the inhibition of numerous other biological systems.

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 http://www.nature.com/nchembio/journal/vaop/ncurrent/abs/nchembio.207.html

[sensual1973]

Seen this on a french site few days ago,and always believed that a better solution would come from a country other than the US. France?,Germany .. ? .

[brazilianman]

 

www.jbc.org/cgi/reprint/M800066200v1.pdf