the opinion of Cancer Research UK about Dr. nabuto claim.
...But my questions remain: why, instead of simply discussing papers, no peer examines a patient "cured" by Dr. Yamamoto or tries out the same protocol?
I'm instinctively sceptical, too. Nevertheless, is it possible that NO PEER took the trouble to examine just ONE of the 15 patients Dr. Yamamoto claims having eradicated HIV from and to ESTABLISH THE TRUTH once and for all?I agree with you Leit
What are NIAID's SOS (http://forums.poz.com/index.php?topic=24749.0) for, if nobody cares to other researchers' work and verifies the results they claim???
Georgep77Maybe they don't want to lose time with Nobuto's research :'(
Why nobody from Gates foundation reply to you ? Have you sent the email to the right address ?
The reseaerch presented at FOCIS 2009 is not the research pubblished in January.
You are clearly supposed to believe that it is major; but I suspect that it is only big news in the Federation Of Canteens In Schools ;)
Complete eradication is impossible to say with 100% accuracy due to the fact HIV can hide in many places that can't be tested for the virus (ie: the brain). There is also a question about the patient who had the bone marrow transplant ------ calling it a functional cure ( not that there's anything wrong with that!). Anything that can help safely toward that end is worth pursuing .
v
Maybe it's because my eyes tend to glaze over when I read these articles, but nowhere did I see mention of viral load testing
... Since when was Nagalase activity levels an indication of the eradication of hiv infection? Am I missing something? ???
Ann
(who wants to know)
Look on the bright side --------- the injections could be subcutaneous!!!! (lol).
I think you have precisely fingered the weak point in both the cancer and the HIV papers; he has concluded that Nagalase activity is a marker for cancer activity and HIV and infers that reduction in Nagalase activity to normal levels indicates a cure.
He does not verify that inference using modern tests for HIV.
Nor does he cite to anyone else who has verified that this secondary marker (Nagalase) is or remains a reliable indicator in the presence of therapy that directly targets Nagalase.
You have simply posted a list of members of the editorial board of a journal. They aren't actually endorsing a single word of Dr. Nobuto Yamamoto's 'research'.
You are wrong, the scientific members must have absolutely approved the published research, don't forget that is a peer-review scientific magazine. How come you claim the scientific members do not approve a single word of Dr. Nobuto ? Have you got more informations ?
The mistake, of course, is to have thought that peer review was any more than a crude means of discovering the acceptability — not the validity — of a new finding.Richard Horton, editor of the The Lancet
You are wrong, the scientific members must have absolutely approved the published research, don't forget that is a peer-review scientific magazine. How come you claim the scientific members do not approve a single word of Dr. Nobuto ? Have you got more informations ?
PS: I assume the mention of "University of Pennsylvania" in one of Bobitalia's posts was a typo because if they are involved with this it does give the whole thing more credibility.
No, it isn't a typo; but nor does it imply the University of Pennsylvania's direct involvement or endorsement.
http://www.ncbi.nlm.nih.gov/pubmed/19031451 (http://www.ncbi.nlm.nih.gov/pubmed/19031451)
FOCIS MEETING 2009
POSTER T.101. _Treatment_of_HIV-Infecte d_Patients_with_Gc_Protei n-Derived_Macrophage_Acti vating_Factor_(GcMAF)_and _Its_Cloned_Derivative_(G cMAFc)_Eradicates_HIV-Inf ection_
Nobuto Yamamoto1, Masumi Ueda1, Kazuya Hashinaka1, Theodore Sery1, Charles Benson2. 1Socrates Institute for Therapeutic Immunology, Philadelphia, PA; 2University of Pennsylvania, Philadelphia, PA
Serum Gc protein (known as vitamin D-binding protein) is the precursor for the principal macrophage activating factor (MAF). The MAF precursor activity of serum Gc protein of HIVinfected patients was lost or reduced because Gc protein is deglycosylated by serum alpha-N-acetylgalactosami nidase (Nagalase) secreted from HIV-infected cells. Since Nagalase is the intrinsic component of gp120, serum Nagalase was already complexed with anti-HIV immunoglobulin G (IgG) in patient blood stream. The IgG-bound virions were infectious and retained Nagalase activity, leading to immunosuppression. Stepwise treatment of purified serum Gc protein or its cloned Gc protein with immobilized beta-galactosidase and sialidase generated the most potent MAF (termed GcMAF or GcMAFc, respectively) ever discovered, which produces no side effect in humans. Macrophages activated by intramuscular administration of GcMAF or GcMAFc (100 ng/patient) developed a large amount of Fc-receptors as well as enormous variation of receptors that phagocytize IgG bound and unbound HIV virions. Cells harboring HIV provirus were unstable and spontaneously released the virions at a high rate. After less than 18 weekly intramuscular administrations of 100 ng GcMAF or GcMAFc to twenty-four nonanemic patients, they exhibited healthy control level of Nagalase activity, indicating eradication of HIV-infection. Since GcMAFc has a potentmitogenic activity on myeloid progenitor cells (MPC), intravenous administration of GcMAFc allowed rapid interaction of GcMAFc with MPC in bone marrow and the systemic cell counts of the activated macrophages increased to 220-fold in 2 days. Weekly intravenous administration of 100 ng GcMAFc to HIV-infected patients eradicated HIV-infection in 8-13 weeks.
instead of making assumptions on the reliability of this approach, why no clinic or research group tries to repeat the experiment to see if it works?you are right xman, yamamoto is talking about eradication and healthy CD + cell counts maintained for 7 years, this could lead to enormous progress in the treatment of HIV.
i only see a lot of articles and a lot of scepticism. no study that i'm aware of proves insuccess of this procedure. if i'm wrong correct me.
you are right xman, yamamoto is talking about eradication and healthy CD + cell counts maintained for 7 years, this could lead to enormous progress in the treatment of HIV.
The question is, why a huge research like this.... remain unnoticed?
Another telling point is the type of journal in which the research was published. If this research was truly groundbreaking, and pointed the way to a cure for cancer, then the research would likely be found in top-tier ’high-impact’ medical journals journals like The Lancet, The New England Journal of Medicine or the Journal of the American Medical Association.