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Meds, Mind, Body & Benefits => Research News & Studies => Topic started by: leit on December 21, 2008, 01:39:03 pm

Title: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: leit on December 21, 2008, 01:39:03 pm

Dr. Nobuto Yamamoto claims he eradicated HIV using "Gc protein-derived Macrophage Activating Factor" (GcMAF):

Immunotherapy of HIV-infected patients with Gc protein-derived macrophage activating factor (GcMAF) (http://www3.interscience.wiley.com/journal/121531612/abstract)

ABSTRACT

Serum Gc protein (known as vitamin D3-binding protein) is the precursor for the principal macrophage activating factor (MAF). The MAF precursor activity of serum Gc protein of HIV-infected patients was lost or reduced because Gc protein is deglycosylated by alpha-N-acetylgalactosaminidase (Nagalase) secreted from HIV-infected cells. Therefore, macrophages of HIV-infected patients having deglycosylated Gc protein cannot be activated, leading to immunosuppression. Since Nagalase is the intrinsic component of the envelope protein gp120, serum Nagalase activity is the sum of enzyme activities carried by both HIV virions and envelope proteins. These Nagalase carriers were already complexed with anti-HIV immunoglobulin G (IgG) but retained Nagalase activity that is required for infectivity. Stepwise treatment of purified Gc protein with immobilized beta-galactosidase and sialidase generated the most potent macrophage activating factor (termed GcMAF), which produces no side effects in humans. Macrophages activated by administration of 100 ng GcMAF develop a large amount of Fc-receptors as well as an enormous variation of receptors that recognize IgG-bound and unbound HIV virions. Since latently HIV-infected cells are unstable and constantly release HIV virions, the activated macrophages rapidly intercept the released HIV virions to prevent reinfection resulting in exhaustion of infected cells. After less than 18 weekly administrations of 100 ng GcMAF for nonanemic patients, they exhibited low serum Nagalase activities equivalent to healthy controls, indicating eradication of HIV-infection, which was also confirmed by no infectious center formation by provirus inducing agent-treated patient PBMCs. No recurrence occurred and their healthy CD + cell counts were maintained for 7 years.


...And it's not the first time:

- FOCIS (Annual Meeting, Federation of Clinical Immunology Societies) 2006:
"Eradication of HIV By Treatment of HIV-Infected/AIDS Patients with Vitamin D-Binding Protein-Derived Macrophage Activating Factor GcMAF (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WCJ-4JYTMW6-FC&_user=10&_origUdi=B6WCJ-4S9KWVT-D&_fmt=high&_coverDate=12%2F31%2F2006&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ad1c7fd4ac3c02358b3f40fd107ce105)"

- FOCIS (Annual Meeting, Federation of Clinical Immunology Societies) 2008 ("Eradicates" - even more explicit title):
"Treatment of HIV-Infected Patients with Gc Protein-derived Macrophage Activating Factor (GcMAF) Eradicates HIV-infection (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WCJ-4S9KWVT-D&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=df82e5bc4925aa466ffea03d83d6accf)"


This is Dr. Nobuto Yamamoto's biography and Personal Insights (http://www.thedcasite.com/Yamamoto_file/Yamamoto_biographical.html).


... And, finally, Catie's warning:
"Cell stimulant touted as yet another cure - proceed with caution (http://www.catie.ca/catienews.nsf/00a48c8905294f0b8525717f00661eb8/59637160717da4f785257520005c5bac!OpenDocument)"
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF
Post by: bimazek on December 21, 2008, 01:56:23 pm
this seems to be from 2006 so it is old news or am i missing something
also for many years i have seen a poz friend of mine who has been struggling for decades and he constantly goes tanning and is very tan, releasing Vitamin D and perhaps helping naturally produce this factor, i am not trivializing this discovery
i am seriously stating that i feel that this one individuals survival is because of his constant tanning and release of vit D and associated factors along with the natural sunshine tanning, that is the only thing this of course he takes meds

Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF
Post by: mecch on December 21, 2008, 02:08:18 pm
I drink red wine. I tan. I had viral loads in the millions. HAART knocked it down thousands fold, in a few days, and now in a few months will knock it to below detection.

Wouldn't it be lovely if red wine soaked beach holidays cured HIV. 
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF
Post by: freewillie99 on December 21, 2008, 02:45:07 pm
This sounds like a joke.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: leit on December 21, 2008, 03:06:19 pm

I'm instinctively sceptical, too. Nevertheless, is it possible that NO PEER took the trouble to examine just ONE of the 15 patients Dr. Yamamoto claims having eradicated HIV from and to ESTABLISH THE TRUTH once and for all?
What are NIAID's SOS (http://forums.poz.com/index.php?topic=24749.0) for, if nobody cares to other researchers' work and verifies the results they claim???

Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: georgep77 on December 22, 2008, 01:05:07 am
Hopefully...   :D

I found this link about Dr, Nobuto

http://www.4marks.com/articles/details.html?article_id=2457
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: georgep77 on December 22, 2008, 06:32:02 pm
the opinion of Cancer Research UK about Dr. nabuto claim.

http://scienceblog.cancerresearchuk.org/2008/12/03/cancer-cured-for-good-gc-maf-and-the-miracle-cure/


                                     :)
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: leit on December 23, 2008, 03:07:06 am

the opinion of Cancer Research UK about Dr. nabuto claim.

VERY interesting, both post and comments!
...But my questions remain: why, instead of simply discussing papers, no peer examines a patient "cured" by Dr. Yamamoto or tries out the same protocol?
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activ
Post by: freewillie99 on December 23, 2008, 08:07:51 am
Quote
...But my questions remain: why, instead of simply discussing papers, no peer examines a patient "cured" by Dr. Yamamoto or tries out the same protocol?

Hmmm...perhaps because Dr. Yamamoto's (aka Mr. Robato) "cure" was a scam, sham, or fraud?  Just sayin.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: georgep77 on December 23, 2008, 11:13:10 am
I just sent an email to Bill & Melinda gates foundation about Dr. nobuto claim, I know they care about alternative solutions, let's see their opinion.

I'm instinctively sceptical, too. Nevertheless, is it possible that NO PEER took the trouble to examine just ONE of the 15 patients Dr. Yamamoto claims having eradicated HIV from and to ESTABLISH THE TRUTH once and for all?
What are NIAID's SOS (http://forums.poz.com/index.php?topic=24749.0) for, if nobody cares to other researchers' work and verifies the results they claim???


I agree with you Leit
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: leit on December 30, 2008, 07:58:46 am

Thanks, "georgep77"!
Please keep us advised!

Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: stargate12 on January 19, 2009, 10:32:04 am
Georgep77

Why  nobody from Gates foundation reply to you ? Have you sent the email to the right address ?


Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: georgep77 on January 19, 2009, 01:29:55 pm
Georgep77

Why  nobody from Gates foundation reply to you ? Have you sent the email to the right address ?



Maybe they don't want to lose time with Nobuto's research  :'(
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Bobitalia on January 27, 2009, 01:34:27 pm
 ;D  http://lilanew.forumup.it/viewtopic.php?t=1888&postdays=0&postorder=asc&start=165&mforum=lilanew (http://lilanew.forumup.it/viewtopic.php?t=1888&postdays=0&postorder=asc&start=165&mforum=lilanew)


 ;D

"Hello there,

I'm afraid I do not speak Italian. I speak English, and I am also a writer.

However, over here (I live in America) Gc-Maf has not been covered by the media at all, and I believe that needs to change. Also, many people here are skeptical.

I have sent some major news agencies information about this treatment, as well as the Bill and Melinda Gates Foundation. However, I believe that we need more spreading of the word this side of the waters if it's to become "big news" here.

I understand from running some posts through Google Translate that you wish to broaden your information campaign to the world. However, the language barrier is a problem for you. If you guys would like, you could send me the letters you'd like to send to the English-speaking world (it's fine if they are in Italian, Google Translate will give me the gist of the message contents. I would then translate them or write you a new letter in English which you could then forward on to the English news agencies of your choice. This could all be done via PM.

What do you say?

EDIT: I apologize for my English. If there is someone here who can speak English and Italian, perhaps you could convey the gist of this message to the other members here? What I'm offering is a concise, well-written, and personalized letter in English to send to news agencies.

Sincerely,
aardvark."

One of your members came over to an American board a while back to talk about the Ensoli vaccine. Out of curiosity I followed the link yesterday and I was thrilled to find not only active discussion of Gc-Maf, but an active campaign to inform the wider world of it.

The english is pretty good, but not perfect. This is why I offered to write English letters for people. Google can confuse words and make things hard to understand. If a letter is written poorly, or with a translator, many people would throw it away.

That is why I'm offering to write English letters to send to American and English news stations - so we can have a real hope of Gc-Maf becoming a reality."
Title: Immunotherapy of HIV-infected patients w/ Gc protein-derived MAF
Post by: Inchlingblue on February 10, 2009, 07:23:22 pm
Has anyone heard of this treatment approach? I read it through once, the language is technical, but it sounds very promising.

http://www.ncbi.nlm.nih.gov/pubmed/19031451
Title: Re: Immunotherapy of HIV-infected patients w/ Gc protein-derived MAF
Post by: stargate12 on June 26, 2009, 05:31:08 pm
What about FOCIS 2009 ?


T.101. Treatment of HIV-Infected Patients with Gc Protein-Derived Macrophage Activating Factor (GcMAF) and Its Coned Derivative (GcMAFc) Eradicates HIV-Infection


Nobuto Yamamoto1, Masumi Ueda1, Kazuya Hashinaka1, Theodore Sery1 and Charles Benson2

1Socrates Institute for Therapeutic Immunology, Philadelphia, PA

2University of Pennsylvania, Philadelphia, PA

Clinical Immunology
Volume 131, Supplement 1, 2009, Page S80
FOCIS 2009 Abstract Supplement - 9th Annual Meeting, Federation of Clinical Immunology Societies

It seems that new Gc-Maf works faster, they claim hiv eradication in 8 - 13 weeks.



Title: Re: Immunotherapy of HIV-infected patients w/ Gc protein-derived MAF
Post by: newt on June 26, 2009, 06:53:29 pm
People who want to read the whole caboodle it's here (PDF):

http://www3.interscience.wiley.com/cgi-bin/fulltext/121531612/PDFSTART

Very promising stufff, kinda seems to be ferrtting along unnoticed.

Pay attention to the CD4 and viral load tables, and the median viral load and proviral scores after treatment.

I wonder what happened after to the 20 odd study subjects.

- matt (no press release) the newt
Title: Re: Immunotherapy of HIV-infected patients w/ Gc protein-derived MAF
Post by: stargate12 on June 26, 2009, 07:35:31 pm
The reseaerch presented at FOCIS 2009 is not the research pubblished in January.
Title: Re: Immunotherapy of HIV-infected patients w/ Gc protein-derived MAF
Post by: Inchlingblue on June 26, 2009, 07:41:37 pm
The reseaerch presented at FOCIS 2009 is not the research pubblished in January.


How can one find what was announced at FOCIS 2009? Do you have a link?

Thanks ;)
Title: Re: Immunotherapy of HIV-infected patients w/ Gc protein-derived MAF
Post by: georgep77 on June 26, 2009, 07:49:29 pm
"healthy CD + cell counts were maintained for 7 years."

The big pharma is not going to be happy with this research   ;)
Title: Re: Immunotherapy of HIV-infected patients w/ Gc protein-derived MAF
Post by: Matts on June 27, 2009, 05:27:03 pm
The J. Med. Virol.study is interesting; all patients  reached undetectable VL and normal CD4 counts after 8 weeks, maintaining for 7 years. Yamamoto had similiar results with Cancer patients.

Arizona State University has developed a similar form of Gc-Maf, but can only use it in animal models, because Yamamoto owns the patent, as G. Ghirlanda told me. Link ASU LAB (http://chemistry.asu.edu/faculty/g_giovanna.asp)
But they founded the company Susavion Biosciences (link), (http://susavion.com/about.html)
and have some patents for Gc-Maf like this one:LINK WiPO (http://www.wipo.int/pctdb/en/fetch.jsp?ELEMENT_SET=B&IDB=0&LANG=ENG&IDOC=1402462&C=10&TOTAL=5&START=1&QUERY=%28PA%2Flaura+AND+PA%2Feggink%29+&FORM=SEP-0%2FHITNUM%2CB-ENG%2CDP%2CMC%2CAN%2CPA%2CABSUM-ENG&TYPE_FIELD=256&SEARCH_IA=US2005044215&DISP=25&SERVER_TYPE=19-10&IA=US2005044215&RESULT=3&DBSELECT=PCT&SORT=41264619-KEY&DISPLAY=DESC) (Laura Eggink,Kenneth J. Hoober)


Immune Research Inc. already offers Gc-maf:Link (http://www.immuneresearchinc.com/index.html)

More about Dr. Nobuto Yamamoto:Link DCA (http://www.thedcasite.com/Yamamoto_file/Yamamoto.html)
A study from 2003 using DBP-maf:Link PDF (http://www.neoplasia.com/pdf/manuscript/v05i01/neo02271.pdf)
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Bobitalia on June 28, 2009, 10:09:08 am
FOCIS MEETING 2009

POSTER T.101. _Treatment_of_HIV-Infecte d_Patients_with_Gc_Protei n-Derived_Macrophage_Acti vating_Factor_(GcMAF)_and _Its_Cloned_Derivative_(G cMAFc)_Eradicates_HIV-Inf ection_

Nobuto Yamamoto1, Masumi Ueda1, Kazuya Hashinaka1, Theodore Sery1, Charles Benson2. 1Socrates Institute for Therapeutic Immunology, Philadelphia, PA; 2University of Pennsylvania, Philadelphia, PA

Serum Gc protein (known as vitamin D-binding protein) is the precursor for the principal macrophage activating factor (MAF). The MAF precursor activity of serum Gc protein of HIVinfected patients was lost or reduced because Gc protein is deglycosylated by serum alpha-N-acetylgalactosami nidase (Nagalase) secreted from HIV-infected cells. Since Nagalase is the intrinsic component of gp120, serum Nagalase was already complexed with anti-HIV immunoglobulin G (IgG) in patient blood stream. The IgG-bound virions were infectious and retained Nagalase activity, leading to immunosuppression. Stepwise treatment of purified serum Gc protein or its cloned Gc protein with immobilized beta-galactosidase and sialidase generated the most potent MAF (termed GcMAF or GcMAFc, respectively) ever discovered, which produces no side effect in humans. Macrophages activated by intramuscular administration of GcMAF or GcMAFc (100 ng/patient) developed a large amount of Fc-receptors as well as enormous variation of receptors that phagocytize IgG bound and unbound HIV virions. Cells harboring HIV provirus were unstable and spontaneously released the virions at a high rate. After less than 18 weekly intramuscular administrations of 100 ng GcMAF or GcMAFc to twenty-four nonanemic patients, they exhibited healthy control level of Nagalase activity, indicating eradication of HIV-infection. Since GcMAFc has a potentmitogenic activity on myeloid progenitor cells (MPC), intravenous administration of GcMAFc allowed rapid interaction of GcMAFc with MPC in bone marrow and the systemic cell counts of the activated macrophages increased to 220-fold in 2 days. Weekly intravenous administration of 100 ng GcMAFc to HIV-infected patients eradicated HIV-infection in 8-13 weeks.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activ
Post by: Inchlingblue on June 28, 2009, 02:17:27 pm
Am I reading this wrong or is this news major?

Bobitalia: Do you by any chance have a link for the above, I was trying to find something with news from FOCIS 2009 and could not.

Thanks ;)
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Luke on June 28, 2009, 02:35:00 pm
You are clearly supposed to believe that it is major; but I suspect that it is only big news in the Federation Of Canteens In Schools ;)
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activ
Post by: Inchlingblue on June 28, 2009, 02:46:17 pm
You are clearly supposed to believe that it is major; but I suspect that it is only big news in the Federation Of Canteens In Schools ;)

I totally understand your cynicism about it but the thing is U. of Pennsylvania and FOCIS are reputable organizations. They wouldn't risk their reputations by making false claims etc.....that's precisely why it sounds so compelling, because the source of the claims is legitimate.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Luke on June 28, 2009, 02:48:12 pm
FOCIS aren't making any claims - 'tis merely smoke and mirrors.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Miss Philicia on June 28, 2009, 03:22:00 pm
Don't be dissin' U-Penn -- I'll have you know it's Ivy League and Miss P. gets her dental service for free there.  They love my AIDS.

That reminds me -- I need to scamper out and see the Sun Ra/Chicago Afro-Futurist Underground exhibit at ICA.

But yeah, Dr. Yamamoto sounds a bit quackish.  I was surprised to see the U-Penn imprimatur.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: positivmat on June 28, 2009, 09:43:50 pm
If you google his name and cancer and the GcMAFc cancer "study" from a while back you will find angry letters from cancer patients about the lack of scientific method used in his research. This "study" seems similar.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Bobitalia on June 29, 2009, 03:22:08 am
1) http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WCJ-4W5XH6K-84&_user=10&_coverDate=12%2F31%2F2009&_alid=942456218&_rdoc=1&_fmt=high&_orig=search&_cdi=6740&_sort=r&_docanchor=&view=c&_ct=7&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e3492a5b0d48987abc7e5492f3e60ad3

2)E D I T O R - I N - C H I E F
ARIE J. ZUCKERMAN
Royal Free and University College Medical School
University College London
London, England
E-Mail: j.m.vir@medsch.ucl.ac.uk



U S E D I T O R
BRIAN W.J. MAHY
Centers for Disease Control and Prevention
Atlanta, Georgia
USA
E-Mail: virology@bellsouth.net



E D I T O R I A L B O A R D


LARRY J. ANDERSON
Centers for Disease Control and Prevention
Atlanta, Georgia
USA



ANN M. ARVIN
Stanford University Medical Center
Stanford, California
USA



ALAN BARRETT
University of Texas Medical Branch
Galveston, Texas
USA



JÜRG BÖNI
University of Zurich
Zurich,
Switzerland



W. DAVID CUBITT
Hospital for Sick Children
London,
England



BETRAM FLEHMIG
Hygiene-Institute der Universität
Tübingen,
Germany



WOLFRAM H. GERLICH
Justus-Liebig Universitat Giessen
Giessen,
Germany



PAUL D. GRIFFITHS
Royal Free and University College Medical School, University College London
London, England



IAN D. GUST
University of Melbourne
Melbourne,
Australia



TIM J. HARRISON
Royal Free and University College Medical School,
University College London
London, England



JACQUES IZOPET
Institut Fédératif de Biologie de Purpan
Toulouse,
France



DENNIS J. MCCANCE
Queen's University
Belfast,
N. Ireland

JOHN F. MODLIN
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire
USA



PHILIP P. MORTIMER
Central Public Health Laboratory
London,
England



ISA K. MUSHAHWAR
Viral Discovery Group, Abbott Laboratories
North Chicago, Illinois
USA


PIERRE ROLLIN
Centers for Disease Control and Prevention
Atlanta, Georgia
USA



B.D. SCHOUB
National Institute of Virology
Sandringham,
South Africa



VINCENTE SORIANO
Hospital Carlos III
Madrid
Spain



LAWRENCE R. STANBERRY
The University of Texas Medical Branch
Galveston, Texas
USA



EDWARD TABOR
Quintiles, Inc.
Rockville, Maryland
USA



G.A. TANNOCK
RMIT University
Victoria,
Australia



STEVEN TRACY
University of Nebraska Medical Center
Omaha, Nebraska
USA



KOICHI YAMANISHI
Osaka University
Osaka,
Japan



A. ZANETTI
Istituto di Virologia
Universita degli studi di Milano
Milano, Italy





TANYA SHENNAN
Royal Free and University College Medical School
University College London
London, England




J o u r n a l P r o d u c t i o n
John Wiley & Sons
Paula Vetrovec
Journal of Medical Virology

Link :

http://www.faqs.org/patents/app/20090041793

http://www.freshpatents.com/-dt20090212ptan20090041793.php

3. google.it  : nagalase, Yamamoto

Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Luke on June 29, 2009, 03:52:57 am
Bobitalia,

You have simply posted a list of members of the editorial board of a journal. They aren't actually endorsing a single word of Dr. Nobuto Yamamoto's 'research'.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: veritas on June 29, 2009, 05:18:22 am


Complete eradication is impossible to say with 100% accuracy due to the fact HIV can hide in many places that can't be tested for the virus (ie: the brain). There is also a question about the patient who had the bone marrow transplant ------ calling it a functional cure ( not that there's anything wrong with that!). Anything that can help safely  toward that end is worth pursuing .

v
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Luke on June 29, 2009, 05:29:19 am

Complete eradication is impossible to say with 100% accuracy due to the fact HIV can hide in many places that can't be tested for the virus (ie: the brain). There is also a question about the patient who had the bone marrow transplant ------ calling it a functional cure ( not that there's anything wrong with that!). Anything that can help safely  toward that end is worth pursuing .

v

True, but Yamamoto gets serious credibility problems when his idea of eradication of HIV is a viral load <400 copies/ml, so not even the <50 copies/ml goal of current antiretroviral treatments.

By his measure, I was cured of HIV within two weeks of starting treatment with Sustiva & Truvada ;)
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: veritas on June 29, 2009, 08:16:26 am

Luke,

I haven't followed Yamamoto's research that closely, so my comment was really meant to be more of a general statement. If he truly said that eradication is a viral load of <400, then I certainly agree his credibility is suspect.
Even the therapy that I am following closely and am very excited about (anti-ps) will really never be able to be proven a cure for the same reasons that I stated above.However,to build an immune response that can functionaly cure HIV without needing a "cocktail" is everybodie's dream.

v
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Ann on June 29, 2009, 08:27:04 am
Maybe it's because my eyes tend to glaze over when I read these articles, but nowhere did I see mention of viral load testing - and I did look for it. All I read was - "After less than 18 weekly intramuscular administrations of 100 ng GcMAF or GcMAFc to twenty-four nonanemic patients, they exhibited healthy control level of Nagalase activity, indicating eradication of HIV-infection." Since when was Nagalase activity levels an indication of the eradication of hiv infection? Am I missing something? ???

Ann
(who wants to know)
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Luke on June 29, 2009, 08:30:51 am
Maybe it's because my eyes tend to glaze over when I read these articles, but nowhere did I see mention of viral load testing

Ann, try CATIE's debunked version: http://www.catie.ca/catienews.nsf/00a48c8905294f0b8525717f00661eb8/59637160717da4f785257520005c5bac!OpenDocument
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Ann on June 29, 2009, 08:40:22 am
Thanks Luke, that's a very informative article - and it didn't make my eyes glaze over! ;)

I found the "cautions and concerns" section quite interesting.

I'm wondering if this might turn out to be a less toxic treatment, even if it isn't a cure - although the thought of weekly intramuscular injections makes me shudder.

Ann
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: veritas on June 29, 2009, 08:46:45 am

Look on the bright side --------- the injections could be subcutaneous!!!! (lol).
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Assurbanipal on June 29, 2009, 08:58:31 am
... Since when was Nagalase activity levels an indication of the eradication of hiv infection? Am I missing something? ???

Ann
(who wants to know)

I think you have precisely fingered the weak point in both the cancer and the HIV papers; he has concluded that Nagalase activity is a marker for cancer activity and HIV and infers that reduction in Nagalase activity to normal levels indicates a cure. 

He does not verify that inference using modern tests for HIV.

Nor does he cite to anyone else who has verified that this secondary marker (Nagalase) is or remains a reliable indicator in the presence of therapy that directly targets Nagalase.

Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Bobitalia on June 29, 2009, 09:11:05 am
mail  Niaid:
NIAID Office of Communications and Government Relations [niaid@AIR.ORG]
A: xxxxxxxxxx - Italy



This is in reply to your inquiry dated January 8, 2009, to the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), concerning an article reported in the January 2009 issue of the Journal of Virology.



While the report of this immunotherapeutic intervention is very interesting and very important, it is early to know whether GcMAF can actually eradicate HIV. Further research, using modern plasma viral load assays, would be important in determining the significance of this treatment.



That said, harnessing the power of the immune system could be a very potent way to treat HIV infection. A number of strategies are being investigated to suppress the virus and enhance resistance to HIV. NIAID will continue to support the fundamental research that will be the foundation for new therapeutic approaches to HIV/AIDS.



We hope this information will be helpful to you.



Sincerely,





Correspondence Specialist

Legislative Affairs and Correspondence Management Branch

Office of Communications and Government Relations

National Institute of Allergy and Infectious Diseases
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Bobitalia on June 29, 2009, 09:15:47 am
mail :
The Hiv Eradication article pubblished by prof. Yamamoto on January 2009 on the scientific Journal Medical Virology, has had little feedback...better say, no feedback at all even by the national and international press too.
This fact is very strange!
Only  some associations have posted the news on their home-pages but the news has dropped away without any feedback.
Some Hiv+ people have activated a series of initiatives to contact the directors of the JMV, responsable of the publication.
The publication of Prof. Yamamoto is rich of significant data and descriptive tables about the research and are of a big impact.
The directors of the magazine, Prof. Zuckerman and Prof. Mahny have answered to the questions, guaranteeing the validaty of the data, eventhough in an elusory way, but at the same time threatening to sue us without any reason. The questions were legitimate and politely done!
Is it possible that nobody wants to comment this article of such a big impact!?
Anyway it has been prepared the following e-mail and sent to the most prestigious agencies.

Dear director  of Aids Operative Centre.
more than 4 months ago has been possible to notice the publishing, on the scientific Jornal Medical Virology, an article on HIV eradication by Prof. Yamamoto, explaining the way he obtained the Hiv eradication in only 18 weeks by injecting, weekly, 100ng GcMAF, an  activating factor of macrophages obtained by the Gc Protein. This is shown by a fully successfull experiment, done  in 2002 on 15 assintomatic Hiv+ patients and non anemic one; these patients have been healthy without having a viral feedback (HIV-RNA, HIV-DNA) and immune alterations such as CD4, CD8 and their percentage absolutely normal) in more than seven years (J. Med. Virol. 81:16-26, 2009).

We have been trying to inquire with the help of the associations, specialists and even embassys without having a feedback, particularly:
1 - [authorised ethic committees]
2 - [centres and patients]
3 - [contacts with the authors]
4 - [contacts with the directors of JMV]
....

Now, since the issue continues to cause serious disturbance among all the Hiv+, and we are not in the best possible conditions, we ask to You and to Your Institution, authority of national importance, to clear up the points above, in order to ascertain whether we are faced with a falsely  clamorous scientific discovery or a true one.
Certainly we would like to see confirmed the latter one. We are convinced that you would put under exam the GcMAF, a low-cost molecule and of an easy preparation, for further clinical trial in case of the results of Prof Yamamoto would be authentic. This would represent the salvation of millions of Hiv+ people all over the world.
Dispite the disappointment in case the trial is not true, we are greatful to You for having provided to us an answer.
Hopefully in an acceptance of our request, we thank and cordially greet.

117 Hiv+ patients.
 


Immunotherapy of HIV-infected patients with Gc protein-derived macrophage activating factor (GcMAF).Yamamoto N, Ushijima N, Koga Y.
Division of Molecular Immunology and Immunotherapy, Socrates Institute for Therapeutic Immunology, Philadelphia, Pennsylvania 19126-3305, USA. nobutoyama@verizon.net

Serum Gc protein (known as vitamin D3-binding protein) is the precursor for the principal macrophage activating factor (MAF). The MAF precursor activity of serum Gc protein of HIV-infected patients was lost or reduced because Gc protein is deglycosylated by alpha-N-acetylgalactosaminidase (Nagalase) secreted from HIV-infected cells. Therefore, macrophages of HIV-infected patients having deglycosylated Gc protein cannot be activated, leading to immunosuppression. Since Nagalase is the intrinsic component of the envelope protein gp120, serum Nagalase activity is the sum of enzyme activities carried by both HIV virions and envelope proteins. These Nagalase carriers were already complexed with anti-HIV immunoglobulin G (IgG) but retained Nagalase activity that is required for infectivity. Stepwise treatment of purified Gc protein with immobilized beta-galactosidase and sialidase generated the most potent macrophage activating factor (termed GcMAF), which produces no side effects in humans. Macrophages activated by administration of 100 ng GcMAF develop a large amount of Fc-receptors as well as an enormous variation of receptors that recognize IgG-bound and unbound HIV virions. Since latently HIV-infected cells are unstable and constantly release HIV virions, the activated macrophages rapidly intercept the released HIV virions to prevent reinfection resulting in exhaustion of infected cells. After less than 18 weekly administrations of 100 ng GcMAF for nonanemic patients, they exhibited low serum Nagalase activities equivalent to healthy controls, indicating eradication of HIV-infection, which was also confirmed by no infectious center formation by provirus inducing agent-treated patient PBMCs. No recurrence occurred and their healthy CD + cell counts were maintained for 7 years.

s.o.s. FROM ITALY
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Ann on June 29, 2009, 09:18:03 am

Look on the bright side --------- the injections could be subcutaneous!!!! (lol).


I did weekly sub-Q injections for a year when I was on Interferon for hep C. They were a horror! I never could bring myself to stick myself - my daughter usually did it for me. I was fine once the needle was in and I could take over from there, but I could never stick it in me. I'd break out in a cold sweat and start shaking! I'm such a wimp when it comes to needles. Intramuscular injections would be even worse, IMO.

I think you have precisely fingered the weak point in both the cancer and the HIV papers; he has concluded that Nagalase activity is a marker for cancer activity and HIV and infers that reduction in Nagalase activity to normal levels indicates a cure.  

He does not verify that inference using modern tests for HIV.

Nor does he cite to anyone else who has verified that this secondary marker (Nagalase) is or remains a reliable indicator in the presence of therapy that directly targets Nagalase.


Thanks for that, I'm glad it's not just me who thought it was strange.

Ann
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: parteboy on June 29, 2009, 09:39:41 am
not sure if its just me but on page 19 of the journal article he describes the method he used to measure viral load

HIV-1 RNA in serum was measured by a RT-PCR kit
(Amplicator HIV-1 Monitor, Roche Diagnostic Systems,
Basel, Switzerland) as described by Hashida et al.
[2000]. The cutoff value of this assay is 400 copies/ml.

whilst 400 copies is not a cure maybe its enough to keep the balance and hence manageable.

Even if this is not a lead its seems as if we constantly write articles about refuting the research. it seems to be discussion paper after discussion paper. why not just check the results, check the patients and then either say yay or nay....

What i am extremely surprised about is the lack of a global reseach catalogue. A central repository of all research that is going on, been done, being thought of. i just read a couple of articles and they are talking about the same thing.... Isn't this just duplication of effort?

Anyway just my thoughts and feel free to correct me if I read the journal incorrectly always up for learning how to read research papers.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: georgep77 on June 29, 2009, 10:02:40 am
Somebody get me the "18 weekly administrations of 100 ng" I'll do it

         I'm going to tell,  if this treatment works or not.

                                     :)

                                        
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Bobitalia on June 29, 2009, 10:12:21 am
if this treatment works or not   :)
OHHHHHHHHHHH
YES!  if or if .

Thank you very much :)
Re: Re: FW: FOCIS 2009Wednesday, June 24, 2009 8:54 PM
From: "nobutoyama@verizon.net" A dd sender to ContactsTo: xxxxxxxxxxx.


Dear xxxxx

I wrote you and ask Dr. Benson to foward it to you (see below). But apparently, he did not. I read your email address to Dr. Benson today.

Regards,

Dr. Yamamoto
-------------------------

Jun 20, 2009 03:24:42 AM, nobutoyama@verizon.net wrote:

Dear xxxx



Up to the recent FOCIS meeting, we presented clinical studies supported by Japanese IRB. We do not plan to present our studies in future HIV Meetings, until US IND approval and clinical studies.


Your statement “amazing results” is over exaggeration. All HIV virions in patient blood stream are bound with anti-HIV IgG (non-neutralizing). Activated macrophages have a large number of Fc receptors that rapidly phagocytize IgG bound virions. In fact, one Japanese group (Nakagawa et al. 2003) already published that oral administration of a feeble macrophage activating agent NK-4 increased CD4 counts and decreased Nagalase activity with Thai HIV-infected patients (Anticancer Res 23: 4389-94).



If you are interested in GcMAF therapy, we are glad to help you as soon as IND approval. In your next communication with us, please identify who you are (e.g., your institution, position and title). Otherwise, our Record Department easily dismisses your request.



Sincerely,



Nobuto Yamamoto, Ph.D., Director

Socrates Institute for Therpeutic Immunology

------------------------- ------------------------- ----------------------


Jun 18, 2009 07:41:58 PM, cebenson@vet.upenn.edu wrote:


Charles E. Benson, Ph.D.
Professor emeritus of Veterinary Microbiology
School of Veterinary Medicine
University of Pennsylvania
Philadelphia, PA 19104
_________________________ _______
From: xxxxxxxxxx
Sent: Thursday, June 18, 2009 5:51 AM
To: Charles Benson
Subject: FOCIS 2009

Dear Charles Benson.

I have read the article available on line http://www.sciencedirect. com/science?_ob=ArticleUR april 2009 ( you have presented that research at FOCIS 2009 T101 Treatment of HIV-Infected Patients with Gc Protein-Derived Macrophage Activating Factor GcMAF and Its Coned Derivative GcMAFc Eradicates HIV-Infection ).

I would like to know if you are planning to present that amazing result at IAS or other well known HIV MEETING.

Would you be so kind to provide me some more information about future clinical trial ?

Best Regards

xxxx

Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: stargate12 on June 29, 2009, 10:38:23 am

You have simply posted a list of members of the editorial board of a journal. They aren't actually endorsing a single word of Dr. Nobuto Yamamoto's 'research'.

You are wrong, the scientific members must have absolutely approved the published research, don't forget that is a peer-review scientific magazine. How come you claim the scientific members do not approve a single word of Dr. Nobuto ?  Have you got  more informations ?
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Luke on June 29, 2009, 10:41:25 am
You are wrong, the scientific members must have absolutely approved the published research, don't forget that is a peer-review scientific magazine. How come you claim the scientific members do not approve a single word of Dr. Nobuto ?  Have you got  more informations ?

Actually, I am not wrong. They are simply the editorial board and are in NO WAY endorsing his claims to have eradicated HIV in his test subjects. Where are you getting your information from? I assume you don't understand the process of peer-review if you think they are agreeing with him.

Also, I didn't actually say anything at all about not approving what Yamamoto says. I said that they hadn't endorsed it. Subtle, but very crucial, difference. Clearly it has been approved for publication; but in a month of Sundays that can't be stretched to imply that they in any way agree with his conclusions.

Quote
The mistake, of course, is to have thought that peer review was any more than a crude means of discovering the acceptability — not the validity — of a new finding.
Richard Horton, editor of the The Lancet
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Assurbanipal on June 29, 2009, 11:02:36 am
You are wrong, the scientific members must have absolutely approved the published research, don't forget that is a peer-review scientific magazine. How come you claim the scientific members do not approve a single word of Dr. Nobuto ?  Have you got  more informations ?

Publication of a paper in a peer reviewed scientific journal does not mean that each member of the editorial board agrees with all statements made in the paper.  In fact few, if any, of the members of the editorial board may have read the paper before publication.  The editorial board usually serves as a pool that recruits authors and papers, recruits peer reviewers and oversees the procedures for review at a rather general level.  They don't all get involved in the review of each individual paper.

Assurbanipal (who has both published and peer reviewed)
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activ
Post by: Inchlingblue on June 29, 2009, 01:13:54 pm
According to the CATIE article, re: the 400-limit viral load assay,

In these five people, viral loads fell to low or so-called undetectable levels over the course of the first six weeks of the study. Bear in mind that the viral load assay used in the study had a lower-limit of quantification of 400 copies/mL. More sensitive assays with a lower-limit of quantification ranging between 75 and 40 copies/mL are routinely used in high-income countries such as Japan. That the MAF research team used an older and less-sensitive assay is unusual and suggests that its pilot study was done many years ago when high-sensitivity viral load assays were not yet available. As a result of using the 400-copy assay, it is possible that low-level viral replication that the assay could not detect was taking place in study participants.

It's also possible the viral loads could have been as low as undetectable or <50 but there's no way to tell if 400 was the lower limit of that particular assay.

This work obviously needs to be repeated, which is the hallmark of any experiment worth it's salt: can it be reproduced? If that is ever done, more advanced and sensitive viral load assays can be used and the validity of the therapy can be better assessed.

It's confusing to know where things stand with this, at the very least it deserves a closer look and legitimate peer review.

PS: I assume the mention of "University of Pennsylvania" in one of Bobitalia's posts was a typo because if they are involved with this it does give the whole thing more credibility.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activ
Post by: Luke on June 29, 2009, 01:41:10 pm
PS: I assume the mention of "University of Pennsylvania" in one of Bobitalia's posts was a typo because if they are involved with this it does give the whole thing more credibility.

No, it isn't a typo; but nor does it imply the University of Pennsylvania's direct involvement or endorsement.

http://www.ncbi.nlm.nih.gov/pubmed/19031451 (http://www.ncbi.nlm.nih.gov/pubmed/19031451)
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activ
Post by: Inchlingblue on June 29, 2009, 01:59:27 pm
No, it isn't a typo; but nor does it imply the University of Pennsylvania's direct involvement or endorsement.

http://www.ncbi.nlm.nih.gov/pubmed/19031451 (http://www.ncbi.nlm.nih.gov/pubmed/19031451)


I didn't see any mention of University of Pennsylvania in the link you provided. It's possible I missed it but I looked carefully. The Socrates Institute for Therapeutic Immunology, which is mentioned and is in Philadelphia I believe is Yamamoto's company.

I do think that an established Ivy League institution such as U Penn would not want their name anywhere near any research that would tarnish their stellar reputation. I'm still not convinced they are involved though, the only indication seems to be one of Bobitalia's posts on this thread.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Luke on June 29, 2009, 02:07:22 pm
You are 100% correct there, Inchlingblue. My bad!. Looks like someone took a few mischievous editorial liberties to add some credibility ;)
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activ
Post by: Inchlingblue on June 29, 2009, 02:11:14 pm
FOCIS MEETING 2009

POSTER T.101. _Treatment_of_HIV-Infecte d_Patients_with_Gc_Protei n-Derived_Macrophage_Acti vating_Factor_(GcMAF)_and _Its_Cloned_Derivative_(G cMAFc)_Eradicates_HIV-Inf ection_

Nobuto Yamamoto1, Masumi Ueda1, Kazuya Hashinaka1, Theodore Sery1, Charles Benson2. 1Socrates Institute for Therapeutic Immunology, Philadelphia, PA; 2University of Pennsylvania, Philadelphia, PA

Serum Gc protein (known as vitamin D-binding protein) is the precursor for the principal macrophage activating factor (MAF). The MAF precursor activity of serum Gc protein of HIVinfected patients was lost or reduced because Gc protein is deglycosylated by serum alpha-N-acetylgalactosami nidase (Nagalase) secreted from HIV-infected cells. Since Nagalase is the intrinsic component of gp120, serum Nagalase was already complexed with anti-HIV immunoglobulin G (IgG) in patient blood stream. The IgG-bound virions were infectious and retained Nagalase activity, leading to immunosuppression. Stepwise treatment of purified serum Gc protein or its cloned Gc protein with immobilized beta-galactosidase and sialidase generated the most potent MAF (termed GcMAF or GcMAFc, respectively) ever discovered, which produces no side effect in humans. Macrophages activated by intramuscular administration of GcMAF or GcMAFc (100 ng/patient) developed a large amount of Fc-receptors as well as enormous variation of receptors that phagocytize IgG bound and unbound HIV virions. Cells harboring HIV provirus were unstable and spontaneously released the virions at a high rate. After less than 18 weekly intramuscular administrations of 100 ng GcMAF or GcMAFc to twenty-four nonanemic patients, they exhibited healthy control level of Nagalase activity, indicating eradication of HIV-infection. Since GcMAFc has a potentmitogenic activity on myeloid progenitor cells (MPC), intravenous administration of GcMAFc allowed rapid interaction of GcMAFc with MPC in bone marrow and the systemic cell counts of the activated macrophages increased to 220-fold in 2 days. Weekly intravenous administration of 100 ng GcMAFc to HIV-infected patients eradicated HIV-infection in 8-13 weeks.


Bobitalia:  Do you have a link that leads to the above post? Thanks.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activ
Post by: Inchlingblue on June 29, 2009, 02:28:54 pm
Dr. Joel Gallant was asked about this and here is his response:

Interesting! I'd have to see the actual data rather than just the abstract, but my biggest concern is that their definition of "eradiction" is normal nagalase activity, which, as far as I know, is no one else's definition. I'm curious to know what evidence there is for eradication besides having a normal nagalase level.

I hope this gets presented at an HIV-related conference, such as the upcoming IAS meeting in Cape Town, and that we see more data and more studies from this group.


LINK:

http://www.hopkins-hivguide.org/q_a/patient/recent_questions/yamamoto_focis_2009.html?contentInstanceId=490040&siteId=7151
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Bobitalia on June 30, 2009, 03:07:24 am
I do not speak English.
I am an HIV-positive boy.
in italy small group of activists.  >:(
against pharmaceutical companies and associations. >:(
I believe and I do not think a Yamamoto. but silence is suspicious.

1
February 9, 2009 at 9:17 am
I have read some opinions about Yamamoto?s research that was pubblished in The Journal of medical virology january 2009.
Yamomoto?s study deserves far more than the weak brief once-over given to it by CATIE.
Yamamoto?s scientific background is impressive.
Preclinical peer-review researches pubblished in Nature magazine about MAF.
1990 http://www.nature.com/icb/journal/v68/n2/abs/icb19 9019a.html
1993 http://www.nature.com/icb/journal/v71/n4/abs/icb19 9329a.html
1998 http://www.nature.com/icb/journal/v76/n3/abs/icb19 9833a.html.
Nature has extremely stringent standards for publication, and will reject papers that report good quality scientific work if editors feel the
work is not a breakthrough in the field. Such journal generally has a two-tier reviewing system. In the first stage, members of the editorial board verify
that the paper s findings  if correct  would be ground-breaking enough to warrant publication in Nature. Most papers, more and less 95 %, are rejected at this stage. Nature publishes about 5 percent of received papere. Papers that do pass this pre-reviewing are sent out for in-depth
review to outside referees. Even after all reviewers recommend publication and all reviewer criticisms/suggestions for changes have been met, papers may still be returned to the authors for shortening to meet the journal s length limits.
And
http://www.pubmedcentral.nih.gov/articlerender.fcg i?artid=1502120 ( the MAF
results come from other researchers in different university and hospital ).
Vitamin D Binding Protein-Macrophage Activating Factor (DBP-maf) Inhibits Angiogenesis and Tumor Growth in Mice1
Oliver Kisker,* Shinya Onizuka, Christian M Becker, Michael Fannon, Evelyn Flynn,* Robert D?Amato, Bruce Zetter, Judah Folkman, Rahul Ray, Narasimha Swamy, and Steven Pirie-Shepherd??
*Division of Surgical Research, Children?s Hospital, Boston, MA 02115, USA
Department of General Surgery, University Hospital Marburg, Philipps University, Marburg, Germany
Department of Surgery II, Nagasaki University School of Medicine, Nagasaki, Japan
§Department of Gynecology and Obstetrics, University Hospital Benjamin Franklin, Free University Berlin, Berlin, Germany
¶Department of Ophthalmology Harvard Medical School, USA
#Department of Surgery and Cell Biology, Harvard Medical School, USA
**Bioorganic Chemistry and Structural Biology, Vitamin D Laboratory, Department of Medicine, Boston University, Boston, MA 02118, USA
Department of Pediatrics, Brown Medical School, Providence, RI, USA
Attenuon LLC, San Diego, CA 92121, USA
Address all correspondence to: Steven Pirie-Shepherd, Attenuon, LLC, 10130 Sorrento Valley Road, Ste B, San Diego, CA 92121, USA. E-mail: shepherd@attenuon.com
Also corresponding author: Narasimha Swamy, Department of Pediatrics, Brown Medical School, 101 Dudley Street, Providence, RI, USA. E-mail: nswamy@wihri.org
Received August 30, 2002; Accepted September 27, 2002.
Moreover the most important cancer meeting in USA.
2004
http://aacrmeetingabstracts.org/cgi/content/abstra ct/2004/1/287-b
2005 http://www.aacrmeetingabs tracts.org/cgi/content/ab stract/2005/1/1423-c.
Among the members of the Editorial Board of The Journal of Medical Virology, there is CDC of Atlanta.
It is very difficult to believe that CDC gave green light to pubblish Yamamoto?s declaration about HIV ERADICATION without scientific evidence.
I trust much more CDC than any other..
E D I T O R - I N - C H I E F
ARIE J. ZUCKERMAN
Royal Free and University College Medical School
University College London
London, England
E-Mail: j.m.vir@medsch.ucl.ac.uk
U S E D I T O R
BRIAN W.J. MAHY
Centers for Disease Control and Prevention
Atlanta, Georgia
USA
E-Mail: virology@bellsouth.net
Why the study and results that were pubblished in Cancer Research, Nature, The Journal of medical virology, Clinical immunology, Aids research
magazine (and many others ) has not been proved wrong yet?.. ?
After 7 years the accademic questions about proviral hiv dna pcr are
worthless.

2.

Meeting FOCIS 2007 - "Treatment of HIV-infected Patients with Vitamin D-binding Protein Derived Macrophage Activating Factor (GcMAF) Eradicates HIV-Infection"
Meeting FOCIS 2008 - "Treatment of HIV-Infected Patients with Gc Protein-derived Macrophage Activating Factor (GcMAF) Eradicates HIV-infection"
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: veritas on June 30, 2009, 04:32:55 am

Bobitalia,

Your quote:

"Nature has extremely stringent standards for publication, and will reject papers that report good quality scientific work if editors feel the
work is not a breakthrough in the field"

I agree with your quote. "Nature" is the foremost journal for breakthrough technology (if its published in "Nature" ---- pay attention.)
The links you provided for MAF did not work for me. Could you relink in another way?

Thanks,
v
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Ann on June 30, 2009, 04:43:35 am
V, try these:

http://www.nature.com/icb/journal/v68/n2/abs/icb199019a.html

http://www.nature.com/icb/journal/v71/n4/abs/icb199329a.html

http://www.nature.com/icb/journal/v76/n3/abs/icb199833a.html

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1502120

http://aacrmeetingabstracts.org/cgi/content/abstract/2004/1/287-b

http://www.aacrmeetingabstracts.org/cgi/content/abstract/2005/1/1423-c

Bob's links have spaces in them in weird spots. ::)

About par for the course in this thread, eh?

Ann
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Luke on June 30, 2009, 05:07:47 am
It is a shame I'm not a mouse.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: xman on June 30, 2009, 03:17:08 pm
instead of making assumptions on the reliability of this approach, why no clinic or research group tries to repeat the experiment to see if it works?

i only see a lot of articles and a lot of scepticism. no study that i'm aware of proves insuccess of this procedure. if i'm wrong correct me.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Ann on June 30, 2009, 07:24:32 pm
Someone requested that another, similar thread (Immunotherapy of HIV-infected patients w/ Gc protein-derived MAF) be merged with this one. I've merged them and so now posts #14 thru #20 are the posts from that thread, which is reflected in the subtitle of those posts. (They were happily all grouped together when the threads were merged.) Just letting you all know so as to avoid confusion. Hopefully. ;)

Ann
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: georgep77 on July 01, 2009, 12:46:28 am
instead of making assumptions on the reliability of this approach, why no clinic or research group tries to repeat the experiment to see if it works?

i only see a lot of articles and a lot of scepticism. no study that i'm aware of proves insuccess of this procedure. if i'm wrong correct me.
you are right xman, yamamoto is talking about eradication and healthy CD + cell counts maintained for 7 years, this could lead to enormous progress in the treatment of HIV.

The question is,  why a huge research like this.... remain unnoticed?
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Luke on July 01, 2009, 06:24:21 am
you are right xman, yamamoto is talking about eradication and healthy CD + cell counts maintained for 7 years, this could lead to enormous progress in the treatment of HIV.

The question is,  why a huge research like this.... remain unnoticed?

Because, to put it quite simply, Yamamoto isn't showing anyone anything that is worth getting excited about.

For starters, if he is so convinced of his own findings and these patients are still healthy after all this time; why isn't he testing them to the latest gold standard assays? The cost of doing that certainly can't be an issue - so why isn't that happening? If there is anything to this, then getting people excited is within his control.

Until then, the vast majority of people are going to remain justifiably sceptical about something that has seen more false hopes shattered than I have had hot dinners.

More to the point, why aren't the people who are writing to Dr Yamamoto asking him why he isn't doing any of this? Is getting him a good Google ranking really more important than getting to the truth?

And who is to say that it has gone unnoticed? Who is to say that there aren't dozens of scientists beavering away at similar approaches, but who have more sense than to make the exaggerated claims that Yamamoto already has a reputation for making? (http://scienceblog.cancerresearchuk.org/2008/12/03/cancer-cured-for-good-gc-maf-and-the-miracle-cure/ (http://scienceblog.cancerresearchuk.org/2008/12/03/cancer-cured-for-good-gc-maf-and-the-miracle-cure/))

As Cancer Research UK noted about Yamamoto's over-hyped claims about having found a cure for cancer:

Quote
Another telling point is the type of journal in which the research was published. If this research was truly groundbreaking, and pointed the way to a cure for cancer, then the research would likely be found in top-tier ’high-impact’ medical journals journals like The Lancet, The New England Journal of Medicine or the Journal of the American Medical Association.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activ
Post by: Inchlingblue on July 01, 2009, 01:42:41 pm
I think part of what's going on here is that Yamamoto wants to patent the manufacturing process of Gc-maf,

GcMAF is a naturally made molecule and is not patentable, though its manufacturing process is patent protected.

LINK:

http://www.rexresearch.com/yamamoto/yamamoto.htm


That's why there are limitations on the studies with Gc-Maf going on at Arizona State University.

The letter below is from Yamamoto to someone who had written him, it sounds like he is waiting for a patent on Gc-Maf manufacturing to be approved:


May 31, 2008

Dear Shylock,

We have exhausted GcMAF stock. We hope to prepare new stock of GcMAF in a few months. We keep your information until approval for commercialization of GcMAF. However, our institute is non-profit organization and we can collaborate with your group for cancer therapy.

Incidentally GcMAF is the most powerful curative remedy for HIV disease. We are glad to help you for GcMAF therapy of tuberculosis and hepatitis.

Regards,

Dr. Nobuto Yamamoto, Director

Socrates Institute for Therapeutic Immunology

LINK:

http://scienceblog.cancerresearchuk.org/2008/12/03/cancer-cured-for-good-gc-maf-and-the-miracle-cure/

PS: I sent AMFAR an email about Yamamoto and Gc-Maf, calling it to their attention in case they are not aware of it.
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activ
Post by: Inchlingblue on July 13, 2009, 12:25:46 pm
I thought this was interesting, from the Johns Hopkins website:

Posted on Jul 8, 2009

Dear Doctor Gallant,

Besides nagalase, Dr. Nobuto Yamamoto published the (astonishing!) values of the established immunovirological HIV infection markers ONCE, in the "Journal of Medical Virology" [http://www3.interscience.wiley.com/cgi-bin/fulltext/121531612/PDFSTART - tables I and III], where he claimed he cured 15/15 patients (100%!!!) in 18 weeks, as confirmed by a 7 years follow-up.

Too bad, it was impossible to obtain any documentation (IRBs certification, "cured" patients' records...) proving those data either from the author or the directors of the journal [http://www3.interscience.wiley.com/journal/32763/home/EditorialBoard.html]. Nonetheless, the latter keep refusing to retract the article.
Quite fishy, isn't it?

On Jul 11, 2009 Joel E. Gallant, M.D., M.P.H. replied:

It's certainly interesting, but I'll have to take your word for the facts of the case, not having researched it myself. It's worth noting that this paper in which "eradiction" of HIV was reported was only published in the Journal of Medical Virology. I suspect that the editors and reviewers from more widely read journals were also dubious about the value of "nagalase levels" as an indicator of cure. But if Yamamoto is really on to something, I'm sure we'll hear more.

LINK:

http://www.hopkins-hivguide.org/q_a/patient/recent_questions/yamamoto_focis_2009.html?contentInstanceId=490040&siteId=7151
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: Bobitalia on August 15, 2009, 04:51:00 am
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Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: sensual1973 on August 15, 2009, 09:45:39 am
ok , please this is quiet technical and complicated for me to understand,can you just brief it in a simple way for us to understand ?

thanx
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activ
Post by: Inchlingblue on August 15, 2009, 10:58:27 am
Bobitalia: Can you give some context for this letter? Obviously it seems to be written by Nobuto Yamamoto but can you supply any more information?
Title: Re: Dr. Nobuto Yamamoto claims he eradicated HIV using GcMAF, a macrophage activator
Post by: J220 on August 17, 2009, 02:34:59 pm
Sounds like a croc of s*** to me....and I'm one of the resident optimists! Until he shows solid data, if it walks like a quack and sounds like a quack....well, you know the rest. Luckily there's other bona fide research out there to be hopeful about (e.g. VRX496, etc.)