POZ Community Forums
Meds, Mind, Body & Benefits => Research News & Studies => Topic started by: georgep77 on February 25, 2011, 09:52:03 am
-
it successful, it can be envisioned that KP-1461 would be given together with an anti-viral regimen such as Atripla and after a year or so, the viruses could be mutated out of existence and patients could achieve a cure.
The magnitude of disruption from such a technology to the current $12B HIV market would be drastic and completely game changing.
http://www.koronispharma.com/pdf/110126%20Wedbush%20Report%20(Re-%20Gilead-Koronis).pdf
-
Very interesting. I'm a bit concerned about some terms used in that article like acquire/stifle competitors. Could this mean they intend to stop or alter development?
-
I get the impression that if little Koronis was working on yet another long-term therapy, Gilead would be going after merger (if anything), but this is something they would like to "stifle" (their word).
-
My guess is, if Gilead felt threatened by Koronis, they would buy the rights to the technology, put it in a box and close the lid... for a long time. Given the less than stellar results from the Koronis studies, Gilead could merely state that additional in-house investigation raised doubts about efficacy and the company has terminated research of KP-1461... simple as that.
If Gilead thought it did work, it would be an ace in their hand, to be ressurected when a credible threat emerged from a competitor. Remember, commercial companies are in business to maximize profit. Their fudiciary responsibility is to their shareholders, not their patients.
This is why public and non-profit funding (like the Gates foundation and Hughes Medical) is so important. They help keep the rest of the industry ethical.
-
Latest on Koronis - KP-1461
http://www.telegraph.co.uk/finance/newsbysector/pharmaceuticalsandchemicals/8378101/HIV-drug-firm-Koronis-Pharmaceuticals-eyes-London-listing.html
-
There are hoardes of scientists at universities and national institutes who play a watchdog role over the pharma industry and any attempt to squash a cure would never work.
Big Pharma conspiracy theories have some value, cause big pharma can do shitty things.
But lets get real.
-
Pass me my deck chair - matt
-
Sounds great but how does it target virus in the reservoirs?
-
Hi ppp-
I don't know if it will answer your question fully, but there was a lot of discussion about that in the thread
"the return of kp 1461 in 2010"
http://forums.poz.com/index.php?topic=29122.0
-
I get the impression that if little Koronis was working on yet another long-term therapy, Gilead would be going after merger (if anything), but this is something they would like to "stifle" (their word).
Accord to this information some big companies, love stifling competition:
http://www.bloomberg.com/news/2011-03-24/glaxo-accuses-abbott-of-stifling-competition-in-aids-drug-price-increase.html
>:(
-
You know what the worst is.. is when people tell me there IS already a cure.. but the pharmcompanies don't want to let it out.. I have a hard time believing this. It would get out for sure. But it makes me nervous that so many people are convinced of this. I'm not one for conspiracy theories.. and obviously a cure is very important to me. It seems like they're just one small breakthrough away from it... but it's very elusive *_*
-
i hear the same thing for cancer too. i put that in the back of my mind and hope that ethics and stuff like that really are in the forfront and that no one could have a cure for these heinous diseases and not let us have them. maybe im naive.
-
You know what the worst is.. is when people tell me there IS already a cure.. but the pharmcompanies don't want to let it out.. I have a hard time believing this. It would get out for sure. But it makes me nervous that so many people are convinced of this. I'm not one for conspiracy theories.. and obviously a cure is very important to me. It seems like they're just one small breakthrough away from it... but it's very elusive *_*
I hate when people say that. Its so dumb to say such a thing.
-
I don't see how these companies would be able to keep a cure a secret, with the number of people who are involved in the research. Also, I think while there is a ton of money to be made in the treatment, a cure could also be big bucks because of the numbers of people who have it. Also, you'd probably still have people contracting the virus for many many years. The first company to come up with the cure would completely shut down all the others, so they may still have an incentive to do the right thing.
-
They f**king better do the right thing...and there is major money to be made and on top of it the prestige and notoriety that comes with it..and those that would even think about stifling the possibility should be ashamed...
-
As I read this topic a few days ago it got me thinking
When was the last time a disease was cured?
-
I Know u might think otherwise but his name is Timothy Brown and if it can happen to him it can happen to us!
-
^Yep. Thats right ppp333. I like the positive thinking!
4 years later and Timothy Brown still aint got no HIV! It can definitely happen to us. Only time will tell.
Things will only get better as time goes on. It went from people dying like crazy with HIV.....to taking 20+ pills a day to stay alive...... to taking like 10 pills a day...... to a just a few a day....... and now some people take just as little as one a day. Side effects went from super nasty... to mostly tolerable (depending on the med of course).
Whats the next step? Once a week pill? Once a month? A quarterly/semi-annually/annual vaccine like a flu shot? Or even better....Eradication! Who knows? Only time will tell but I'm optimistic things will change soon. :) I don't talk like this usually. I'm usually the one to complain but lately Ive been doing a lot of thinking.... and things could be worse, but its not. Thank god.
-
I do hope ur right...but back to the thread, what is currently going on with KP1461? Are theytrying to raise money for another trial? Would any human participate in this? I mean this is some heavy duty shit but it could be lead to the C word...right now im hoping for this, Sangamo, and still hoping for Dr. sudhir Paul...the race continues I just wish thy would go faster and I know I've not had this long but even being poz for a day is long enough...
-
I really do feel like it's just around the corner..
-
My take is that if a company like GILD that's already making a TON of $$$ from HIV were to sense a real threat, it wouldn't be that they "hide" a cure... they could acquire it and drastically slow down the already slow path to learning if it really works.
I truly doubt if a cure was proven, that it would be kept from the public... too many people involved in trials would know about it to keep it a secret.
-
Does anyone know what is currently being done with KP1461 today? R they looking for investors or r they looking for candidates for a trial...?
-
In any case reading carefully the article of Wedbush it seems that analysts are recommending Gilead to concentrate future investments in other areas like HCV and IPF in consideration of a likely HIV franchise cliff that Gilead could face in the next years.
-
Given the recent drug price increases effected by Gilead, they seem to be anticipating an end to the HIV gravy train. True to their fudiciary duty to the shareholders, they are trying to get as much $$$ out of their HIV franchise while they still can. They could expect any or all of the following; a cure, therapeutic long-term treatment, or less costly generics as patents expire.
-
The most recent financing will be used to conduct Phase II clinical trials. If the trials are successful, Elmer said the company will make a determination whether to partner with a larger pharmaceutical company or to continue going alone with later-stage research.
Of course as a venture capitalist, Elmer knows that multiple problems can arise for an early stage drug company. And that's part of the reason he is trying to guard his optimism.
"We are feeling pretty good about it right now, but we will have to wait and see," he said.
Source (http://www.seattlepi.com/default/article/Koronis-HIV-drug-draws-funding-1242160.php)
Several series of in vitro experiments were done in cell cultures, using a very nasty strain of HIV, a homogeneous, highly fit virus. And after an average 15 serial passages, that virus was irreversibly extinguished--repeatedly. Repeated, published experiments have demonstrated that you can collapse the viral population with KP-1461.
Source (http://findarticles.com/p/articles/mi_m0HSW/is_423/ai_n21055143/pg_2/?tag=content;col1)
In conclusion:
- Koronis' HIV drug draws funding ($20 million to be used for studies)
- in vitro experiments have demonstrated that you can collapse the viral population with KP-1461
- Gilead see KP-1461 as a possible cure for HIV
Reasons to hopes for sure. And if confirmed by the trials results of the new Phase II to come, Koronis won't let the KP-1461 to be buried, even by big pharma let say having bought them:
Nobel Price, saving the world from a deadly virus and still, big money, etc
If KP-1461 is a cure, we will know it sooner or later no matter the scenario, I bet.
-
It is my belief that most drug companies are starting to realize that a cure for HIV is an inevitability and is only a matter of time. The Berlin patient is proof that a cure which was once thought unattainable is a reachable reality. Granted we won't be using the same technique but it is evidence that the virus can at least be eliminated. And like John says if they can be the one to do it first then they will reap a big PR coup not to mention licensing the drug.
-
This is very exciting news...
I went to the web site for the company http://www.koronispharma.com/index.html and had a look around.
Does anyone know whats happened to the people involved in the trials? Did they just say "thanks for the help, see ya later?"
Either way, the whole concept of "wearing out the virus" until it's useless look promising. I hope they get the investors/funding they need and get on with it....
-
Hi pozoz
Previous clinical trials has shown:
- KP-1461 repeatedly caused a permanent eradication of HIV in vitro
- No evidences of drug resistances to KP-1461
- KP-1461 is safe and well tolerated over 80 patients in these early human clinical trials
- Conclusive evidences that KP-1461 cause a significantly increase rate of mutations formations in HIV in early human clinical trials
And that's what has been observed in the clinical trials participants (3 class drugs resistant at entry):
no cure, but a significant increase rate of mutations formations in HIV (124 days trial)
Koronis need now a sophisticated development partner to complete late stage development (full-scale phase II, one or more phase III for regulatory approval)
Now, Koronis draws funding ($20 million to be used for studies) so the second Phase II can start.
This second Phase II have to answer to the following questions:
1. Is KP-1461 able to produce a meaningful reduction in VL?
2. What kind of optimized treatment we will need to get this VL drop?
It's during this new phase II that they will be able to conclude whether or not KP-1461 might or not lead to a cure, be use as a new treatment option, or can be forgotten.
If successful, then the Phase III can start. It will have to compare KP-1461 results against other standard available treatments.
Still a long way to go. The only things we can enjoy now, is the results we already get plus hopes.
-
Hi pozoz
Previous clinical trials has shown:
- KP-1461 repeatedly caused a permanent eradication of HIV in vitro
- No evidences of drug resistances to KP-1461
- KP-1461 is safe and well tolerated over 80 patients in these early human clinical trials
- Conclusive evidences that KP-1461 cause a significantly increase rate of mutations formations in HIV in early human clinical trials
And that's what has been observed in the clinical trials participants (3 class drugs resistant at entry):
no cure, but a significant increase rate of mutations formations in HIV (124 days trial)
Koronis need now a sophisticated development partner to complete late stage development (full-scale phase II, one or more phase III for regulatory approval)
Now, Koronis draws funding ($20 million to be used for studies) so the second Phase II can start.
This second Phase II have to answer to the following questions:
1. Is KP-1461 able to produce a meaningful reduction in VL?
2. What kind of optimized treatment we will need to get this VL drop?
It's during this new phase II that they will be able to conclude whether or not KP-1461 might or not lead to a cure, be use as a new treatment option, or can be forgotten.
If successful, then the Phase III can start. It will have to compare KP-1461 results against other standard available treatments.
Still a long way to go. The only things we can enjoy now, is the results we already get plus hopes.
Cheers John,
Definetely agree we can all be hopefull about this. Something worth following for sure.
I probably would try to get in the trial if I was in the states. Because that's not possible I'd like to thank all those who will be doing the trials for all our benefit, and of course all those who have done so in the past.
-
for reals?
-
I've been following this study a bit closely since, if it delivers what it promises, would make millions of people very happy. I looked at this site:
http://www.koronispharma.com/clinicaltrials.html (http://www.koronispharma.com/clinicaltrials.html)
Phase 2a Trial
An Open-label, Multicenter, Mechanism Validation Study to Evaluate the Safety, Efficacy, and Tolerability of KP-1461 as Monotherapy for 124 Days in ARV-experienced, HIV-1-infected Subjects. This study enrolled 27 of the 32 subjects targeted for the trial. Koronis stopped this trial prior to complete enrollment in order to conduct in vitro serial passage studies, which have confirmed HIV ablation consistent with original preclinical results. The trial closure was not requested or required by the FDA and was not related to any safety concerns or adverse events during the trial. KP-1461 was shown to be well tolerated. Results also demonstrated drug activity as subjects treated with KP-1461 had an increased frequency of HIV mutations that were statistically significant as compared to a separate control group.
It seems that the Phase 2a trial has been suspended, though I don't really understand why. In fact, I can't tell if this is a good thing or a bad thing. Could someone clarify, please? Thanks!
-
As I remember it, there was some issue with Koronis not being able to repeat their earlier in vitro results. So they went back and re-ran their tests. Looks like the got a result similar to their first results -- good news.
-
As I remember it, there was some issue with Koronis not being able to repeat their earlier in vitro results. So they went back and re-ran their tests. Looks like the got a result similar to their first results -- good news.
Ah, that's very good news. Thanks for the clarification. I'm afraid I'm not so well versed with medical speak. :) Keeping fingers crossed!
-
So, like Karl Marx said " capitalism carries the seeds of it's own destruction "
HIV's strength ( its ability to mutate rapidly ) could also be its weakness .
HIV carries the seeds of its destruction in its DNA
Interesting, hope so
-
if they are no risks for the host it should work at least in theory.
-
The concept behind KP-1461 is so basic, I bet the people that developed it slapped their foreheads and exclaimed "Of course, this is so simple!"
The premise is that it encourages the HIV virus to continually and rapidly mutate in random ways, making it worthless in that it cannot reproduce or infect. From what I understood of the Phase II clinical trials, patients were given KP-1461 and Atripla for a year - KP-1461 to damage the viruses already in the system and Atripla to keep the viruses from reproducing as much as possible.
The original version of this post said that 80+ people were cured of HIV... this was wrong, and I apologize. What it really meant was that these people were able to tolerate the medication and it showed a very high rate of mutation of HIV. Here's a link with some better information on what's going on (http://en.wikipedia.org/wiki/Error_catastrophe#KP-1461).
The day this drug is released to the public, I will shed happy tears for the millions of poz people living with HIV, including my friends. Definitely keeping my fingers crossed for this one...
-
How does this deal with latent reserves?
-
How will the scientist or doctors know when the drug can be stopped and viral ablation or collapse has happened and that one can stop KP and Atripla.
-
Koronis Appoints Rondaxe To Secure Commercialization Partner For KP-1461, Possible
Cure For HIV
http://www.pacifichorizon.com/news/1944423439100428%20Koronis%20Rondaxe%20Agreement%20Press%20Release.pdf
(Syracuse, NY. – April 28, 2010) – Rondaxe Enterprises, LLC, announced today that it has
entered into an agreement with Koronis Pharmaceuticals to secure a commercialization partner to
advance an HIV drug known as KP-1461. KP-1461 is currently in phase II clinical trials and is
demonstrating remarkable potential to alter the treatment paradigm for HIV.
“If approved, KP-1461 could significantly advance the treatment of HIV over currently available
agents, and lead to a cure, rather than today’s chronic treatment of the disease,” said Rondaxe’s
James Bergey, Ph.D., who is leading the project. ...
could this be the real deal?
-
I hope so, I really freakin' hope so!
-
I would really like to understand how KP-1461 deals with the virus in the reservoirs. It seems to me that unless there is a specific mechanism of action that allows the drug to reach the reservoirs, that the virus in these reservoirs would remain untouched and unmutated. In that case, I guess KP-1461 would just be another med, albeit one that the virus cannot develop resistance to (which would be a wonderful improvement).
Can someone clear this up for me?
-
From what I understand, KP-1461 is used in combination with another treatment like Atripla, Btripla or the combination therapies out there. Atripla to reduce the viral load, and KP-1461 to damage the viruses themselves by causing them to mutate excessively. Basically, this combination situation causes the viruses in the reservoirs to be released, thereby be vulnerable to KP-1461 and the other meds.
-
I wouldn't be getting to optimistic here. Great that it can cause highly mutated strains of the virus that is actually replicating, but what about the virus that isn't? The main problem with being able to eradicate HIV are the latent cells that it can hide out in. How is taking a medication that can encourage mutations getting HIV out of these cells? Also, wouldn't all these mutations make it even more possible to become resistant to other drugs that you might otherwise be taking to control the virus? So I'd be very cautious before being sold on an idea such as this. Yes, it would work nicely in a system with no latent cells, sure. But unfortunately, that's not reality with HIV. I guess if all you have in your body is a strain that is already resistant to most drugs out there, taking this would be a great option. But I don't see it as a cure unless I'm missing something.
I'm more encouraged by other ideas being researched, such as gene therapy with HIV-resistant CD4's and stem cells, or vaccines that can train the immune system to fight off the virus without the need for medications.
-
I would really like to understand how KP-1461 deals with the virus in the reservoirs. It seems to me that unless there is a specific mechanism of action that allows the drug to reach the reservoirs, that the virus in these reservoirs would remain untouched and unmutated. In that case, I guess KP-1461 would just be another med, albeit one that the virus cannot develop resistance to (which would be a wonderful improvement).
This is an excellent point. After an in-depth conversation with some of the Koronis folks, I'm no closer to understanding how KP-1461 will somehow achieve either a sterilizing or or functional cure, nor am I understanding any of the potential clinical benefits of this agent. The public relations surround this drug appears much more solid than the science. While I understand that PR and resulting press is necessary to spark investment needed to conducted additional Phase II studies looking at clinical efficacy -- which thus far hasn't been demonstrated (a high mutation rate hasn't been proven to be a surrogate marker of anything) -- simply because the word "cure" makes its way into media reports doesn't necessarily make it so.
Once there's proof of concept, we'll all have a lot more to talk about. But we're not there yet, period.
Tim
-
Well, In my opinion...
Until they are half way through Phase 3 research...I wouldnt get my panties in a bunch and overly excited...I have seen sooooooo many trials DIE in late Phase 2 early Phase 3...
Everything looks GOD DAM GREAT when your in Phase 1 and looking for Investors...but I see too many times that after that happens, and the money is in the door... HASTA LA VISTA BAY-BEE ! :-*
-
As the VP Manufacturing & Business Development at Koronis, I wanted to respond to the number of questions/comments on this forum concerning KP-1461’s impact on the virus in the latent reservoirs.
KP-1461 is effective against viruses which are actively replicating. Therefore, if latent reservoirs of virus are activated, this will also enable KP-1461 to be incorporated into these viral genomes and cause progressively deleterious mutations. While the effect of these mutations is not immediate, it stands to reason that successive cycles of reservoir activation in the presence of a VDA agent will result in progressively weakened viruses seeding subsequent reservoirs until the weakened virus is no longer able to elicit a productive infection. Therefore, we believe that use of KP-1461 in conjunction with a compound that activates the latent reservoir could eventually provide a sustained virologic response.
In closing, it is important to note that although there is considerable promise with this therapeutic approach, more studies are required to validate the true potential of VDA and KP-1461 in humans. With this in mind, we are very encouraged by the recently published data from our first Phase 2 study and are actively moving forward with plans for our next study to further evaluate the clinical potential of KP-1461.
-
I'm a little confused. So Phase 2 has been completed with positive results?
-
As the VP Manufacturing & Business Development at Koronis, I wanted to respond to the number of questions/comments on this forum concerning KP-1461’s impact on the virus in the latent reservoirs.
KP-1461 is effective against viruses which are actively replicating. Therefore, if latent reservoirs of virus are activated, this will also enable KP-1461 to be incorporated into these viral genomes and cause progressively deleterious mutations. While the effect of these mutations is not immediate, it stands to reason that successive cycles of reservoir activation in the presence of a VDA agent will result in progressively weakened viruses seeding subsequent reservoirs until the weakened virus is no longer able to elicit a productive infection. Therefore, we believe that use of KP-1461 in conjunction with a compound that activates the latent reservoir could eventually provide a sustained virologic response.
In closing, it is important to note that although there is considerable promise with this therapeutic approach, more studies are required to validate the true potential of VDA and KP-1461 in humans. With this in mind, we are very encouraged by the recently published data from our first Phase 2 study and are actively moving forward with plans for our next study to further evaluate the clinical potential of KP-1461.
Hello Mr. Fromhold:
Thank you for posting this information - it sounds very encouraging. I'm not sure if a missed it or not, but are there thoughts as to how to activate the latent reservoirs, or would this occur as a result of depleting the non-latent active reservoirs. Also, in regards to response time for the successive cycles to be activated and eliminated - is there any idea of how long that would take and/or how long the treatment would need to be to completely eradicate the virus, including the latent resorvoirs from the body?
Thanks again for your response and the work you all are doing.
-Phil
-
As the VP Manufacturing & Business Development at Koronis, I wanted to respond to the number of questions/comments on this forum concerning KP-1461’s impact on the virus in the latent reservoirs.
KP-1461 is effective against viruses which are actively replicating. Therefore, if latent reservoirs of virus are activated, this will also enable KP-1461 to be incorporated into these viral genomes and cause progressively deleterious mutations. While the effect of these mutations is not immediate, it stands to reason that successive cycles of reservoir activation in the presence of a VDA agent will result in progressively weakened viruses seeding subsequent reservoirs until the weakened virus is no longer able to elicit a productive infection. Therefore, we believe that use of KP-1461 in conjunction with a compound that activates the latent reservoir could eventually provide a sustained virologic response.
In closing, it is important to note that although there is considerable promise with this therapeutic approach, more studies are required to validate the true potential of VDA and KP-1461 in humans. With this in mind, we are very encouraged by the recently published data from our first Phase 2 study and are actively moving forward with plans for our next study to further evaluate the clinical potential of KP-1461.
I was under the impression that if we could activate the viral reservoirs then currently existing HAART would do a fine job of destroying the virus. Is that not the case?
-
Obviously all progress towards a cure is welcomed and I am confidentent a "funtional" cure could come about in the next 5 years (at least in the west)
However as we all now there is a masive sigma with this illness that exists in no other and untiil they can STOP 100% the spread of the disease, so that you can not pass on the virus (in sex at least) the sigma will continue and QoL will continue to be low
-
Unfortunately, I'm unable to respond to each individual post, but as a follow-up to my earlier post associated with KP-1461 and the viral reservoirs, I encourage all who are interested to use the following link to access a podcast interview I did with Genetic Engineering & Biotechnology News earlier this year. Accessing the audio file will require you to register for “free access," and the associated interview (~15min) will provide a much more comprehensive overview of KP-1461. Here is the link: http://www.genengnews.com/gen-podcasts/nonsuppressive-drug-therapy-for-hiv/331/
-
is there any updates regarding kp-1461 ? , i dont know but from all the clinical trials and hiv cure research, i bet for kp-1461 . i got a strong feeling about this one , i hope so heheheh
-
@ Meech.. why do you counter every positive thinking?? Are u born this way??? or this virus has changed you this way!! I guess we should keep a positive attitude coz we are positive !! lol .. 8)
-
@ Meech.. why do you counter every positive thinking?? Are u born this way??? or this virus has changed you this way!! I guess we should keep a positive attitude coz we are positive !! lol .. 8)
You are replying to someone's post from a year ago, and Mecch was just pointing out the logic that hiding a cure for HIV would never work.
-
My guess is, if Gilead felt threatened by Koronis, they would buy the rights to the technology, put it in a box and close the lid... for a long time. Given the less than stellar results from the Koronis studies, Gilead could merely state that additional in-house investigation raised doubts about efficacy and the company has terminated research of KP-1461... simple as that.
If Gilead thought it did work, it would be an ace in their hand, to be ressurected when a credible threat emerged from a competitor. Remember, commercial companies are in business to maximize profit. Their fudiciary responsibility is to their shareholders, not their patients.
This is why public and non-profit funding (like the Gates foundation and Hughes Medical) is so important. They help keep the rest of the industry ethical.
I am hopeful for a cure. I am skeptical about conspiracy theories, very prevalent among some people, that "evil" "Big Pharma" or the US Government, or the Illumaniti, have a cure and are hiding it, or will squash a cure, when it is discovered, to maximize profit and return to shareholders. Duh.
-
I think, everyone who has a slight idea of how research in this field works would agree with Mecch. Most of the basic research that has been done has been publicly funded, which means that the results are published and freely available for the benefit of everyone. What pharmaceutical companies do is pick up promising leads and develop them further to the point where they can start clinical trials.
Sangamo for example did not invent the zinc finger nucleases (ZFN). Those existed before and Sangamo just saw the potential of using them to disable the CCR5 gene in CD4 cells. The basic functioning of their approach is no secret. If they don't develop a treatment based on this mechanism and patent it, some other company will give it a shot.
The whole conspiracy theories about a cure held back are just nonsense...
-
You know what the worst is.. is when people tell me there IS already a cure.. but the pharmcompanies don't want to let it out.. I have a hard time believing this. It would get out for sure. But it makes me nervous that so many people are convinced of this. I'm not one for conspiracy theories.. and obviously a cure is very important to me. It seems like they're just one small breakthrough away from it... but it's very elusive *_*
I hate when people say that. Its so dumb to say such a thing.
Out of the hundreds (or thousands) of conspiracy theories made up over the past 300 years, name ONE that ever turned out to be true. That's pretty much how I view each and every conspiracy theory that lingers on and on. Nobody can keep a secret all the way to their death bed. I would like to think we can trust the majority of people would have some sort of basic minimal level of humanity out there.
-
let us not lose hope. Pray. everything is in God's perfect timing. :)
-
let us not lose hope. Pray. everything is in God's perfect timing. :)
Who's God? Does he post here?
-
We need more than just a pray
the CCR5 gene expression in CD4 cells that HIV uses it is very well known at least 10 years before now!!!!
the concept of reservorio is very ambiguous
ARV will NEVER DESToRY THE VIRUS ..... (this is something wery well known too at least 15 year )
The leaves and the branches of a tree can be cut again and again, but once you stop cutting them the tree returns to grow. why? Perhaps because the tree does not die if someone just cut the leaves and the branches. Is the tree hidden? The reservoir could be the roots….
You need to remove the roots in order to kill a tree in many cases
ARV just cut the leaves and the branches.
Why academia are just looking where the virus is hiding. Academia knows where the virus is…
Any approach trying to flush, clean or whatever to the “ reservoir” WIL TAKE MANY MANY YEARS ( Dr. Margolis)