POZ Community Forums
Meds, Mind, Body & Benefits => Research News & Studies => Topic started by: Jmarksto on February 22, 2013, 05:13:04 pm
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The Conference on Retroviruses and Opportunistic Infections (CROI) 2013 runs from March 3 - 6.
Here is a link to the conference program, which includes the specific presentations. I haven't been around for the previous conferences, but this looks pretty comprehensive.
http://zika.retroconference.org/croi-2013-pocket-program.pdf
It should be a news worthy week.
JM
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we need something good this time.
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Sigh, the abstract titles do not look promising...
SB-728-T:
Central Memory T Cell Is the Critical Component for Sustained CD4 Reconstitution
in HIV Subjects Receiving ZFN CCR5 Modified CD4 T Cells (SB97289T)
"Not every patient's CD4 cells went up after our therapy but we think we know why"
"And don't ask us about Viral Load"
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Yellowfever, where did you get this information from?
Did'nt Sangamo say Phase II info was going to be released later this year (meaning not in March, not at CROI)?
Been reading the threads from http://www.investorvillage.com/smbd.asp?mb=1933&mn=50615&pt=msg&mid=12562154 for the past 1/2 hour and can't find any info. Just speculation. Sangamo shares HAVE been going up these past few months...whatever that means( good or bad).
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Tadeys; Their Feb 14, 2013 Leerink Swann Global Healthcare Conference presentation on their website (you have to register, but they let me in)
http://investor.sangamo.com/events.cfm
Indicates that they will present prelim data the 1st half of 2013 (at CROI) for SB-728-902-5 and SB-728-1101, with complete data by the end of 2013. They also indicate they will be Phase 3 "ready" in 2013.
JM
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Thanks JM: but still don't know where yellowfever got his info since CROI has not started... ???
I know this gene therapy CAN work, but it all depende on how much editing can be done on the cells( in terms of porcentaje of over all cells without the gene) ...the more, the better.
My bet is on callimune (RNAi). But still have my fingers crossed for Sangamo.
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Tadeys;
Yellow got the title of the presentation from the CROI program (see the link in the opening post of this thread), although I believe the comments in quotes are really Yellow's him/herself's.
JM
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I saw the title; just can not seem to find the following:
"Not every patient's CD4 cells went up after our therapy but we think we know why"
"And don't ask us about Viral Load"
Perhaps he made it up, but since it is quoted seems that he read it somewhere. somehow I think this is old info Sangamo released...
Thanks
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Some fascinating and promising basic research and some disturbing presentations:
374 HIV Preferentially Infects Hematopoietic Progenitor Cells with High CD4 and Can Be Found in CD133+ Hematopoietic Progenitor Cells in a Subset of Optimally Treated People with Long-term Viral Suppression
Lucy McNamara*, N Sebastian, A Onafuwa-Nuga, J Riddell, D Bixby, and K Collins
Univ of Michigan, Ann Arbor, US
This means that in some individuals the virus is not only in our bone marrows but in (I presume) unipotent "stem"cells, I if I were to guess within the lymphoid lineage which inclueds our T-Cells, both CD4 and CD8, B-cells and natural killer cells. However CD4 is also expressed on monocytes and macrophages too, and there is not enough information in the title to say which hematopoietic population the indentified cells belong to.
Bottom line is, as these progenitors grow up and divide any integrated virus goes along with them-another damn reservoir.
The CD133+: http://en.wikipedia.org/wiki/CD133
CD133, originally known as AC133.[1] CD133 is a glycoprotein also known in humans and rodents as Prominin 1 (PROM1).[2] Currently the function of CD133 is unknown. It is a member of pentaspan transmembrane glycoproteins (5-transmembrane, 5-TM), which specifically localize to cellular protrusions.
CD133 is expressed in hematopoietic stem cells,[3] endothelial progenitor cells,[4] glioblastoma, neuronal and glial stem cells,[5] various pediatric brain tumors,[6] as well as adult kidney, mammary glands, trachea, salivary glands, placenta, digestive tract, testes, and some other cell types.[7][8]
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Yeah Mishma, saw that this morning... :o Stopped reading the CROI pdf after I saw this.
So, What's the good news?
I think gen therapy is the only solution (for now)...hopefully the CD8 cells that are being "trained" to hunt down HIV infected cells also kill off these stem cells.
And Regarding stem cells: did'nt some research show last year that stem cells where NOT infected with hiv? Remember reading it.
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I saw the title; just can not seem to find the following:
"Not every patient's CD4 cells went up after our therapy but we think we know why"
"And don't ask us about Viral Load"
Perhaps he made it up, but since it is quoted seems that he read it somewhere. somehow I think this is old info Sangamo released...
Thanks
Yes, it is my take on the abstract title....
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Yellow, you gave me FEVER! Review your MLA... :P
Regarding Phase II vs III for Sangamo. BASICALLY, Phase II figures out if something works, Phase III compares the product to something similar in the market. There is'nt anything to compare Zinc Fingers to. Yes, there will be a Phase III, but phase II is BIG for Sangamo..although something CAN go wrong in the post I phases.
Ciao
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*pats my own back* for sounding officious. I could really have a career in bullshitting.
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And Regarding stem cells: did'nt some research show last year that stem cells where NOT infected with hiv? Remember reading it.
http://www.nature.com/nrmicro/journal/v9/n5/full/nrmicro2564.html
Alas the CROI 2013 abstract on stem cell "infestation" is not the first paper on the subject. The above link doesn't take you to the abstract, but the title and the fact it is published in Nature would add weight, which these new results
would confirm.
The good news:
Abstract #7 In vivo Imaging. This is huge.
Opening remarks by Stevenson #2
48LB Functional cure with ex early HAART in an infant. This is huge.
All the nano stuff under: New approaches to ARV therapy
The stuff on measuring rectal HIV in GALT
375 and 376 I'll be watching
All the stuff on HIV/SIV-host interaction
A Novel innate HIV-1 neutralizing protein in breast milk.
And a whole lot more but that's all I can peruse tonight.
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This is what I read last year regarding there being NO HIV virus in stem cells:
http://www.hiv-reservoir.net/index.php/the-news/209-no-hiv-reservoir-found-in-hpcs.html
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Thanks Tadeys.
I should of remembered this study as it is on a site I go to periodically.
These were in CD34 cells, which acts as an adhesion molecule and binds CD62L or something called L-selectin. The receptor is found in precursors of hematopoietic cells, and endothelial cells in lymph glands.
Yeah it is damn confusing, for instance the text I reference often didn't have any information on this CD133 receptor (last edition 2012), whose function remains unknown. Without having access to the full paper one can't say with certainty what additional CD markers were present.
During Hemtopoises cells start out first as stem cells with universal potential, then advance to becoming multipotent followed by cells with unipotential before becoming the committed precursors and late differentiated and mature blood cells that we all know. The virus was found in what they call a unipotent lineage so my guess is this is downstream of actual stem cells with universal potential, which is a good thing as it narrows down which cell lineage harbors HIV.
CD stands for clusters of differentiation and we've already identified hundreds. My text goes up to CD363!
As it often goes in science we have seemingly conflicting results which will only get sorted out over time, and of course repeating the experiments over and over.
Plenty of diagrams of the process on the net. I even googled Hematopoiesis for Dummies in the hope they could make better sense out of the process than brain damaged me.
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" I even googled Hematopoiesis for Dummies in the hope they could make better sense out of the process than brain damaged me."
Don't worry. I am medical doctor. One would think that we KNOW this stuff. In med School we take a very basic immunology course...and 75% of what we learn, we forget. :)
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As a bench researcher/lab supervisor I had trouble keeping up with what was going on the next bench. I knew a few physician scientists but they are a rare breed and if they are both, their families can suffer-as demanding as both jobs are. Our daughter is a physician.
I don't know if you saw an earlier comment that I made in one of the forums, but I'm schlepping Abul Abbas's text, "Cellular and Molecular Immunology," which you may have used. I started reading it in 1991 and I'm now reading the 7Th edition-and I still don't know a fraction of what I'd like to know.
Tadeys, check out my other thread on innate immune responses and the review I posted. I've got CD8's coming out my ears and I still haven't eradicated this bastard. I think any functional cure has got to involve tweaking our innate immune response, possibly by silencing integrated DNA through methylation. Of course it is tricky because HIV grabs and incorporates NFkb, a key transcription factor, into it's promoter region.