Reyataz/Norvir boost - precise timing necessary?

[mecch]

Does one have to precise in time, for taking Reyataz with Norvir boost and Truvada?  My ID switched me last week from Sustiva/truvada. On that combo, he told m to take it before bed, no matter what time, 11pm or 3am didnt matter.  He said i could do the same with Reyataz - at dinner - but didn't matter what time dinner is each day....

I see some people are very concerned to take Reyataz on precise schedule.
I thought Norvir boost was to keep consistent levels. 
I asked this question in another thread, but didn't get an answer.

So- everyday the exact same time, or is a couple hours difference not a big deal?

Is my ID correct, I would hope so?

[newt]

Hello hello

I wouldn't fret about precise time, just once a day.

A typical length for a therapeutic dose on Reyataz is 28 hours +/- 4 << but hmm, don't be one of the few who are nearer 24- than 36+ please.

As for the Norvir, it makes not a jot squit when you take it, the boosting effect is not related completely to timing - besides the straightforward get the drug level up boosting effect it does something to your liver metabolism which helps keep PI levels up, so brekkie, lunch or with a nightcap, with or separate from the rest of the drugs, will do.

I personally am completely flaky about by Reyataz timing, lunch one day, dinner the next, and it makes sod all effect on my viral load << do not copy me people -- and so are most of my friends << do not copy them either.

In short, I agree with your doc. This is quite a robust drug time wise. Likewsie Truvada. Once a day will do, don't fret on the time is what my doc said too.

This reminds me I must really go to clinic on Monday, it's been 6 months now.

Actually I am fibbing about the completely flaky, it's never more than +4 extra hours after i am due a dose, I am pretty strict thinking about it, I just enjoy, and take advantage of, the flexibility.

- matt

[mecch]

Thanks Newt. Amazing comprehensive answer as always. I feel better.

Now I hope I don't turn yellow.  Those disagreable Sustiva "skin chills" dissappeared mid-week, by the way, a couple days off the drug.  You were the only one to report someone else having that (your ex??) and I had to push my doc to switch me off. 

Nice to know all this medicine does control virus, however.  Millions down to 120, I feel good about that, that's for sure! 

Thanks again.

[a2z]

Thanks Newt. Amazing comprehensive answer as always. I feel better.

Now I hope I don't turn yellow.  Those disagreable Sustiva "skin chills" dissappeared mid-week, by the way, a couple days off the drug.  You were the only one to report someone else having that (your ex??) and I had to push my doc to switch me off. 

Nice to know all this medicine does control virus, however.  Millions down to 120, I feel good about that, that's for sure! 

Thanks again.

We'll find out how flexible it is for myself.  I've tried to keep to the following time adherance (-45 minutes to +5 minutes) and have violated 4 times in 6 1/2 weeks.  (100 minutes, 180 minutes twice, and 40 minutes) -- I take my bloodwork tomorrow and find out on the 10th.

I work with hundreds of people of which 10-15 see me on a daily basis.  Only 3 of which noticed I had slightly yellowed.  Two of them didn't say yellow...one said I looked the different and the other was relieved I got some color because I was looking "mighty white."  The third was an-ex-nurse and she looked closer...she was afraid of hepatitis (it's not) and urged I talk to my doc.  But she said it was barely noticeable.  No one suspected I was on HIV meds.  And everyone else noticed no change, or didn't say.

[hotpuppy]

I dyed my hair blond as a disguise /distraciton.

my study doc says the half lives are very long for reyataz/norvir.  I believe he mentioned 36 hours.

I take mine with breakfast.  I also have an alarm set in outlook to remind me.  so my blackberry goes off and my computer goes off and my laptop bugs me if I happen to open it in the morning.  That helps me not forget.  One morning my routine got disrupted and I missed a dose because I was stressed out about dealing with something else.

doc said no big deal, just don't make a habit of it.

I do have the slight yellowing thing... but it's not bad most of the time.  It was worse initially.  Sure wish they could avoid that.

[mecch]

Im ever so slightly yellow after about 2 weeks. But being a pale person naturally I think it improves the situation, as long as i ski all winter, i'll be tan on top of yellow...  Oh who the heck cares, as long as my eyes dont turn piss yellow and I can ski and work and have fun, I can't really complain.

Thanks for the half life info. 

[weasel]

I take mine with breakfast between 8am-9am

never miss a dose . works for me .

My doctor told me same time everyday , then later backed off and said a few hours did not matter .
but I like to do it same time .

                          hope it works for you , i am olive  to begin with so nobody ever notices

 i am off color 

                                                                             karl