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Author Topic: Combivir and Skin Discloration/Hyperpigmentation  (Read 3601 times)

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Offline Ralffey

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  • Posts: 4
Combivir and Skin Discloration/Hyperpigmentation
« on: November 13, 2006, 08:31:06 pm »
Hi,
I started taking meds(Sustiva and Epizicom) in April 2006.
Within two weeks of taking this combo, I had a severe allergic reaction and had to stop this regimen completely.
My doctor then put me on Combivir and Lexiva.
Almost immediately my VL went undetectable and my Tcells increased dramatically. 

Problem:
My skin is getting darker and darker and darker.
My doctor thinks that AZT can cause the darkening of skin in some black patients.
I'm not vain, but this is real noticeable.

I want to switch AZT out of my regime and take Viread, but I've heard that Viread can cause kidney problems.
Right now my kidneys, liver, heart, lungs, etc. are fine.  Should I switch and risk another set of sides effects?
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Offline newt

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  • Posts: 3,900
  • the one and original newt
Re: Combivir and Skin Discloration/Hyperpigmentation
« Reply #1 on: November 14, 2006, 02:47:38 am »
AZT is the most likely cause of this rare but important side effect, but it could, at an outside chance, be the 3TC in Combivir too.

Switiching to Viread will probably help.  Provided your kidney function is normal to start with, the chance of kidney problems from Viread is very, very low. Viread has a kinder side effect profile short and long term than AZT.

- matt
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"The object is to be a well patient, not a good patient"
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