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Author Topic: Connection Between Smallpox Vaccine and HIV  (Read 6179 times)

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Offline edfu

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Connection Between Smallpox Vaccine and HIV
« on: May 19, 2010, 05:05:42 am »
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"No one will ever be free so long as there are pestilences."--Albert Camus, "The Plague"

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Offline Assurbanipal

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Re: Connection Between Smallpox Vaccine and HIV
« Reply #1 on: May 19, 2010, 07:45:21 am »
Fascinating.  What if we had a vaccine that cut transmission rates perceptibly (and could get people vaccinated). 
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5/06 VL 1M+, CD4 22, 5% , pneumonia, thrush -- O2 support 2 months, 6/06 +Kaletra/Truvada
9/06 VL 3959 CD4 297 13.5% 12/06 VL <400 CD4 350 15.2% +Pravachol
2007 VL<400, 70, 50 CD4 408-729 16.0% -19.7%
2008 VL UD CD4 468 - 538 16.7% - 24.6% Osteoporosis 11/08 doubled Pravachol, +Calcium/D
02/09 VL 100 CD4 616 23.7% 03/09 VL 130 5/09 VL 100 CD4 540 28.4% +Actonel (osteoporosis) 7/09 VL 130
8/09  new regimen Isentress/Epzicom 9/09 VL UD CD4 621 32.7% 11/09 VL UD CD4 607 26.4% swap Isentress for Prezista/Norvir 12/09 (liver and muscle issues) VL 50
2010 VL UD CD4 573-680 26.1% - 30.9% 12/10 VL 20
2011 VL UD-20 CD4 568-673 24.7%-30.6%
2012 VL UD swap Prezista/Norvir for Reyataz drop statin CD4 768-828 26.7%-30.7%
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Offline TabooPrincess

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Re: Connection Between Smallpox Vaccine and HIV
« Reply #2 on: May 19, 2010, 03:24:17 pm »
Smallpox vaccine isn't recommended for those with compromised immunity?  It sounds like a nasty vaccine...don't really understand the connection tbh but sounds interesting....
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09/ 2008 - Seroconversion
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12/2008 - cd4 794 vl 27798, 35%
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08/2009 - cd4 464 vl 54662, 32%
Started meds for pregnancy (Kaletra, AZT, Viread)
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10/2009 - cd4 860 vl 1088, 41%
11/2009 - cd4 771 vl 563, 38%
12/2009 - cd4 885 vl 151 42%
Discontinued meds after baby born
02/2010 - cd4 841 vl 63781, 38%
05/2010 - cd4 1080 vl 113000, 39%
08/2010 - cd4 770 vl 109242
12/2010 - cd4 642 vl 111000, 34%
06/2011 - cd4 450 vl 222000, 33%
11/2011 - cd4 419 vl 212000, 24%
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05/2012 -cd4 360 vl 99,190
10/2012 Atripla, cd4 690, vl 80
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Offline Matty the Damned

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Re: Connection Between Smallpox Vaccine and HIV
« Reply #3 on: May 19, 2010, 04:36:42 pm »
Quote from: TabooPrincess on May 19, 2010, 03:24:17 pm
Smallpox vaccine isn't recommended for those with compromised immunity?  It sounds like a nasty vaccine...don't really understand the connection tbh but sounds interesting....

Smallpox vaccine is not derived from the smallpox virus (variola) rather it's made from live vaccinia virus aka cowpox. Vaccinia is closely related to the virus which causes smallpox and provides immunity to both.

From my reading of the article in the OP this is about smallpox vaccination somehow making people less susceptible to HIV infection rather than using it as a therapeutic approach in HIV poz folks.

That said, smallpox vaccination is contraindicated for HIV positive people.

MtD
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Offline mecch

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Re: Connection Between Smallpox Vaccine and HIV
« Reply #4 on: May 20, 2010, 01:02:05 am »
I read it differently.  From an epidemiology perspective.  Smallpox vaccine maybe made populations more likely to express HIV infections as LTNP - infected but suppressed, thus the few infected with HIV did not spread the disease because they weren't shedding much virus.
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Offline BlackLion

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Re: Connection Between Smallpox Vaccine and HIV
« Reply #5 on: May 20, 2010, 03:01:07 am »
Quote from: mecch on May 20, 2010, 01:02:05 am
I read it differently.  From an epidemiology perspective.  Smallpox vaccine maybe made populations more likely to express HIV infections as LTNP - infected but suppressed, thus the few infected with HIV did not spread the disease because they weren't shedding much virus.

Yes, I agree with you.
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Offline Boze

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Re: Connection Between Smallpox Vaccine and HIV
« Reply #6 on: May 21, 2010, 06:00:33 pm »
I am sceptical. Smallpox vaccinations normally happened after birth. In this study

"Researchers looked at the ability of white blood cells taken from people recently immunised with vaccinia (cowpox virus used to vaccinate against smallpox) to support HIV replication.

They found significantly lower HIV replication in blood cells from such individuals."

They should be looking at blood cells of people vaccinated after birth - which is when most developed countries did it.

Also - vaccinations stopped in 1971 in the US and 1978 in Russia. So everybody born before those days should've been vaccinated - ie all the people who were sexually active in 80s-90s.

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==========
Aug08 - Seroconversion
Mar10 - Diagnosis; cd4 690 - VL 19,000
Apr10 - cd4 600
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Offline TabooPrincess

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Re: Connection Between Smallpox Vaccine and HIV
« Reply #7 on: May 22, 2010, 05:38:12 am »
Quote from: borzel on May 21, 2010, 06:00:33 pm
I am sceptical. Smallpox vaccinations normally happened after birth. In this study

"Researchers looked at the ability of white blood cells taken from people recently immunised with vaccinia (cowpox virus used to vaccinate against smallpox) to support HIV replication.

They found significantly lower HIV replication in blood cells from such individuals."

They should be looking at blood cells of people vaccinated after birth - which is when most developed countries did it.

Also - vaccinations stopped in 1971 in the US and 1978 in Russia. So everybody born before those days should've been vaccinated - ie all the people who were sexually active in 80s-90s.



I thought the vaccinations only lasted 3-5 years?  Which would tally....
Logged
09/ 2008 - Seroconversion
11/2008 - Tested pos, cd4 640 vl 25400
12/2008 - cd4 794 vl 27798, 35%
03/2009 - cd4 844 vl 68846, 35%
06/2009 - cd4 476 vl 49151, 33% (pregnancy confirmed)
08/2009 - cd4 464 vl 54662, 32%
Started meds for pregnancy (Kaletra, AZT, Viread)
09/2009 - cd4 841 vl 3213, 42%
10/2009 - cd4 860 vl 1088, 41%
11/2009 - cd4 771 vl 563, 38%
12/2009 - cd4 885 vl 151 42%
Discontinued meds after baby born
02/2010 - cd4 841 vl 63781, 38%
05/2010 - cd4 1080 vl 113000, 39%
08/2010 - cd4 770 vl 109242
12/2010 - cd4 642 vl 111000, 34%
06/2011 - cd4 450 vl 222000, 33%
11/2011 - cd4 419 vl 212000, 24%
03/2012 - cd4 280 vl 118000, 26% (repeated Cd4 at 360)
05/2012 -cd4 360 vl 99,190
10/2012 Atripla, cd4 690, vl 80
12/2012 Darunavir, norvir, truvada, Cd4 680, vl u/d
07/2013 cd4 750,ud

Offline Boze

  • Member
  • Posts: 477
Re: Connection Between Smallpox Vaccine and HIV
« Reply #8 on: May 22, 2010, 06:55:27 am »
Princess,

you're absolutely right (http://familydoctor.org/online/famdocen/home/healthy/vaccines/740.html). So then it does make sense.
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==========
Aug08 - Seroconversion
Mar10 - Diagnosis; cd4 690 - VL 19,000
Apr10 - cd4 600
May10 - VL 4,500
Jun10 - started Atripla ; VL 113
Jul 10 - UD vl, CD4 590
Aug 10 - UD, CD4 810, 52%
Nov 10 - UD, CD4 980

Offline veritas

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  • Posts: 1,410
Re: Connection Between Smallpox Vaccine and HIV
« Reply #9 on: May 22, 2010, 08:03:35 am »
The relationship between smallpox and hiv has been known for quite awhile. Both viruses use the same ccr5 receptor. The vaccine might have helped if one was vaccinated before contracting hiv, however, mtd is correct, the smallpox vaccine is contra-indicated for those with HIV:

http://www.cmaj.ca/cgi/content/full/162/3/406

However, the potential for new therapies exist with more research.

v
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