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Author Topic: Complera & 400 Calorie Meal  (Read 10595 times)

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Offline sanduneboi

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Complera & 400 Calorie Meal
« on: April 30, 2012, 04:19:20 pm »
Not sure if this should go here or in the nutrition area.

My question is what are the issues if I take my medication without taking it with at least 400 calories? Will it be less effective in some way?
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Offline leatherman

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Re: Complera & 400 Calorie Meal
« Reply #1 on: April 30, 2012, 05:23:35 pm »
Quote from: sanduneboi on April 30, 2012, 04:19:20 pm
Will it be less effective in some way?
Yes. drugs with the requirement to be taken with food, absorb differently and less effectively without being accompanied by food. Too maintain the correct level of meds in your system complera must be taken with food. as to how many calories, you would have to look at the information on the package insert to find out that.
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leatherman (aka Michael)

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Offline Hellraiser

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Re: Complera & 400 Calorie Meal
« Reply #2 on: May 01, 2012, 01:01:34 am »
Quote from: leatherman on April 30, 2012, 05:23:35 pm
Yes. drugs with the requirement to be taken with food, absorb differently and less effectively without being accompanied by food. Too maintain the correct level of meds in your system complera must be taken with food. as to how many calories, you would have to look at the information on the package insert to find out that.

It's 400, like in the thread title.
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Offline leatherman

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Re: Complera & 400 Calorie Meal
« Reply #3 on: May 01, 2012, 01:16:34 am »
a little googling ("complera package insert") and I found this in the Pharmacokinetics section:
Quote
total calorie content of the meal was approximately 400 kcal with approximately 13 grams of fat

Single-dose administration of Complera tablet to healthy subjects under fasted conditions provided approximately 25% higher exposure of rilpivirine
so the answer to what happens w/o food is that the level of rilpivirine/Edurant is about 25% higher than it would be with 13 grams of fat in a 400 kcal meal

the package insert (http://www.gilead.com/pdf/complera_pi.pdf) does provide this caveat also:
Quote
Effects of Food on Oral Absorption 
Take COMPLERA with a meal. A food effect trial was not conducted for COMPLERA.
Therefore, the specific effect of food with COMPLERA tablets on rilpivirine, emtricitabine and tenofovir exposure has not been established. The recommendation to administer COMPLERA with a meal is based on the increased exposure that was observed when rilpivirine tablets were administered under fed conditions.
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leatherman (aka Michael)

We were standing all alone
You were leaning in to speak to me
Acting like a mover shaker
Dancing to Madonna then you kissed me
And I think about it all the time
- Darren Hayes, "Chained to You"

Offline sanduneboi

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Re: Complera & 400 Calorie Meal
« Reply #4 on: May 01, 2012, 04:05:49 am »
Quote from: leatherman on May 01, 2012, 01:16:34 am
a little googling ("complera package insert") and I found this in the Pharmacokinetics section:so the answer to what happens w/o food is that the level of rilpivirine/Edurant is about 25% higher than it would be with 13 grams of fat in a 400 kcal meal

the package insert (http://www.gilead.com/pdf/complera_pi.pdf) does provide this caveat also:

 ;D Thank you for that.
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Offline 2manyquestions

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Re: Complera & 400 Calorie Meal
« Reply #5 on: May 01, 2012, 05:13:36 am »
One question I have is : is it better to take complera without a meal or wait to take it with a meal?

Today, I missed me standard "time" that I take my meds.  Being new to this I had a meal and forgot to take them.  I realized this 30 min later and wasn't sure if I should take it immediately or wait for my next meal?  I chose to eat another 500 cal meal within a few hours to play it safe as I've heard the life of complera in your system is around 36 hours.

Any thoughts?
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Offline surf18

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Re: Complera & 400 Calorie Meal
« Reply #6 on: May 01, 2012, 07:25:14 am »
that is exactly why i said no thanks to this drug when it came out. too much work to have to take with a meal. ha
ill wait for quad pill.
also the drama that happens if you take it with acid reflux meds too.
way to many rules for a pill in this day and age.
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Offline leatherman

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Re: Complera & 400 Calorie Meal
« Reply #7 on: May 01, 2012, 09:45:58 am »
Quote from: surf18 on May 01, 2012, 07:25:14 am
too much work to have to take with a meal.
that's funny. LOL
I pop a Reyataz/Norvir/Truvada with dinner every night (because a person's gotta eat sometime during the day, right?) and think nothing of it. Taking pills with a meal is one of the easiest regimens out there. To be honest, it's just as easy as taking a pill at any other time of the day. (quite a few meds have restrictions about antacids because, just like food, that affects absorption)
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leatherman (aka Michael)

We were standing all alone
You were leaning in to speak to me
Acting like a mover shaker
Dancing to Madonna then you kissed me
And I think about it all the time
- Darren Hayes, "Chained to You"

Offline leatherman

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Re: Complera & 400 Calorie Meal
« Reply #8 on: May 01, 2012, 09:47:25 am »
Quote from: 2manyquestions on May 01, 2012, 05:13:36 am
I realized this 30 min later and wasn't sure if I should take it immediately or wait for my next meal?
30 mins later? I would have taken the pill.
An hour and a half later or more? I would have taken it with the next meal, or had a snack later on.
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leatherman (aka Michael)

We were standing all alone
You were leaning in to speak to me
Acting like a mover shaker
Dancing to Madonna then you kissed me
And I think about it all the time
- Darren Hayes, "Chained to You"

Offline Miss Philicia

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Re: Complera & 400 Calorie Meal
« Reply #9 on: May 01, 2012, 10:26:34 am »
ONE pill a day, with food -- my my folks, that is just so damn difficult. It's not like we all eat every day... something.
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Offline sanduneboi

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Re: Complera & 400 Calorie Meal
« Reply #10 on: May 01, 2012, 01:11:54 pm »
Quote from: Miss Philicia on May 01, 2012, 10:26:34 am
ONE pill a day, with food -- my my folks, that is just so damn difficult. It's not like we all eat every day... something.

HA!
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Offline gadawg1979

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Re: Complera & 400 Calorie Meal
« Reply #11 on: June 19, 2012, 01:24:25 am »
To be blunt I have found if you are not at 400 it gives me a massive case of the runs.....
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Diagnosed March 2012
Initial CD4- 156 VL 200K (started Complera) Genotype test no resistance
First labs on meds CD4- 246 VL 2K Taken after 30 days on Complera
90 Day labs VL 306 No CD4 Drawn
8/21/2012 CD4 474 VL Undetectable (40) %20.6
11/27/2012 CD 4 522 VL Undetectable (40)
2/14/2013 CD 4 464 VL Undetecable (30) 19.6%
6/8/3013 CD 4 528 VL Undetectable (30)
9/24/2013 CD 4 546 VL Undetectable (40)
1/30/2014 CD4 560 VL Undetectable (40) 22 %
6/19/2014 CD4 584 Vl Undetecable (30)

Offline Hellraiser

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Re: Complera & 400 Calorie Meal
« Reply #12 on: June 19, 2012, 10:13:06 am »
The only problem I've had with it is the nausea.  When I wake up the next morning I am nauseous for probably an hour or so.  When I eat it seems to go away.
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