A Study to Evaluate CJC1295 in HIV Patients With Visceral Obesity

[The Canuck]

Hello everyone,

I am participating into this study and thought it might be of interest for some of you. When Kaletra became part of my regimen I started to have cholesterol problems ( way too high ) and within 8 months gained about 20-25 pounds, where a lot of it was located in the abdominal part of my body. When switching to Reyataz / Norvir my cholesterol went back to normal but unfortunately my abdominal fat remained.

http://www.clinicaltrials.gov/ct/show/NCT00267527

We were told there wouldn't be any significant changes before weeks #6. No one on this study at my clinic noticed any improvements at week #6 either. It was actually my case too and received the number #8 shot this past Wednesday.

One guy had a dramatic ( meant in a nice way ) decrease of his abdominal fat between week #7 & 8. In my case , it looks like change are appearing as well. I noticed some fats is going away in that region and confident the next few weeks will show even more noticeable change.

Unfortunately I was the only one at my clinic who had the worst side effects. The worst being a change in my humour ( bad mood ) and my feet/hands were getting swollen a little ( uncomfortable ). However it was possible to diminish the dose every week if desired for avoiding side effects. I did this two times and things went back to normal including my normal humour ( good mood ).

I still have 4-5 weeks to go into this study and will keep you posted at the end for the results.

Regards,

The Canuck

[RAB]

Canuck

Interesting, I hadn't heard anything about this.

Thanks for the info, I'll be curious to hear about your updates.

RAB

(Who would actually like to gain weight, but like Canuck is carrying a paunch he hates!)

[Lisa]

I will be awaiting any encouraging word as well. I have developed an untenable amount of abdominal/breast obesity over the several years of being on the Viramune/Trizivir combo. It really has become quite distressing for me, and is causing physical problems as well.
I would like to participate in such a trial.

[The Canuck]

Hi y'all !

Last week I received my 11th injection out of 12. The results are far from being spectacular but felt I still had some results since I don't feel anymore like having ate for three after only one sandwich by example, which was the case before I entered into this study.

I'll never get the injection #12 though. I received a phone call this morning telling me the study was halted. Indeed an Argentinian died a few hours after his 11th injection ( lucky me I had that one too  ), but since I had it last Wednesday it sounds like I'll make it. 

They aren't sure if his death is related to the study but in such cases it had to be halted.

Regards,

The Canuck