Welcome, Guest. Please login or register.
March 29, 2024, 11:37:03 pm

Login with username, password and session length


Members
  • Total Members: 37614
  • Latest: bondann
Stats
  • Total Posts: 772964
  • Total Topics: 66312
  • Online Today: 741
  • Online Ever: 5484
  • (June 18, 2021, 11:15:29 pm)
Users Online
Users: 0
Guests: 124
Total: 124

Welcome


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Do I Have HIV?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Canadian-developed HIV vaccine approved for human studies  (Read 6524 times)

0 Members and 1 Guest are viewing this topic.

Offline Cosmicdancer

  • Member
  • Posts: 199
Canadian-developed HIV vaccine approved for human studies
« on: December 20, 2011, 08:44:23 pm »
This vaccine will be given to 40 HIV positive volunteers starting in January.  I'm puzzled by the theory behind using a killed whole HIV virus, since my understanding is that even when the immune system recognizes HIV, it cannot develop a sufficient immune response since the envelope constantly mutates.  If the vaccine can generate antibodies that target the conserved regions of HIV, maybe it will have some success.

http://www.thestar.com/news/canada/article/1104653--hiv-vaccine-developed-in-canada-approved-for-human-studies?bn=1

Canadian-developed HIV vaccine approved for human studies

After two decades of research, a group of Canadian scientists has won approval to start testing an experimental HIV vaccine on humans.

The vaccine, developed by researchers at the University of Western Ontario, has received a green light from the U.S. Food and Drug Administration for clinical human trials.

Beginning in January, the vaccine will be given to 40 healthy people with HIV to test its safety.

Dr. Chil-Yong Kang, professor of virology at the Schulich School of Medicine and Dentistry at the University of Western Ontario, called the FDA approval a “milestone.”

“We started the basic science research two decades ago,” Kang said. “The vaccine development, we started 10 years ago. This is incredible for us to get to this stage of development.”

Kang said the vaccine, called SAV001, is the first preventative HIV vaccine approved for clinical trials to use a killed whole HIV-1 virus to activate the immune response in humans.

The strategy has been used before to develop successful vaccines for influenza, polio, rabies and hepatitis A. Kang said these past successes for other viral diseases provide hope the Canadian-developed vaccine will work against HIV.

The human immunodeficiency virus used in the vaccine has been genetically altered to render it non-pathogenic, or unable to cause disease. Kang and his research team then further inactivated the virus using chemicals and radiation.

“In the past, people did not use this strategy (using a killed whole HIV virus) because people did not know how to make a safer virus and people did not know how to make large quantities of it,” Kang said. “Now we have solved those problems by the genetic engineering of the virus.”

According to the International AIDS Vaccine Initiative, there are 30 HIV vaccines currently being tested in phase 1 clinical trials around the world.

Many of these vaccines have largely focused on using one specific component of the human immunodeficiency virus to trigger an immune response. Other vaccines have used other viral vectors to create a vaccine. Right now, there is no effective HIV vaccine.

Dr. Jonathan Angel, president of the Canadian Association for HIV Research, whose research is funded by the Canadian Institutes of Health Research, said it is exciting that a Canadian scientist’s work has progressed from the basic research level to a vaccine approved for human clinical trials, meeting the rigorous criteria of the FDA.

But he also cautioned that developing an effective HIV vaccine remains a daunting task because HIV is a complex virus that scientists do not yet completely understand.

Should the SAV001 be proven safe, the vaccine will enter the second phase of clinical trials, in which it will be tested on 600 HIV-negative volunteers at high risk for HIV infection. Researchers will measure the volunteers’ immune response to the vaccine.

The third and final phase would enroll 6,000 HIV-negative volunteers at high risk for the disease. The participants, half of whom would be vaccinated and half un-vaccinated, would be tracked for three years to see how many in each group became infected with HIV.

Kang and his team received funding from Sumagen Canada, a company created in 2008 to support the development of the vaccine and a subsidiary of a Korean-based pharmaceutical venture company.
Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
2/2008 - 5/2015 - undetectable on Atripla
May, 2015 - UD, switched to Complera
September, 2015 - UD, 980 cd4, switched to Stribild (Complera interacted with acid reflux medication)
January, 2016 - Stribild, UD, 950 cd4
June, 2016 - UD, 929 cd4

Offline MiniPozToyota

  • Member
  • Posts: 206
Re: Canadian-developed HIV vaccine approved for human studies
« Reply #1 on: December 20, 2011, 11:58:33 pm »
Hope it works, sounds interesting...
April 2010- tested neg.
April 1 2011 -  CD4 346 VL 46856 22%
July 27 2011- Started Atripla
(Meds are good) needed more space to update been UD now for three years. Current down below
Jun 5 2014 - CD4 704 VL UD % 44.0

Offline leatherman

  • Global Moderator
  • Member
  • Posts: 8,595
  • Google and HIV meds are Your Friends
Re: Canadian-developed HIV vaccine approved for human studies
« Reply #2 on: December 21, 2011, 01:25:44 am »
the vaccine will be given to 40 healthy people with HIV to test its safety.
they're not looking for it to have any therapeutic value, are they? Is this just a test so if it doesn't kill off the pozzies, ;D then they'll give it to the neggies to see what happens if/when they get infected?
leatherman (aka Michael)

We were standing all alone
You were leaning in to speak to me
Acting like a mover shaker
Dancing to Madonna then you kissed me
And I think about it all the time
- Darren Hayes, "Chained to You"

Offline AlexMerida

  • Member
  • Posts: 28
Re: Canadian-developed HIV vaccine approved for human studies
« Reply #3 on: December 21, 2011, 09:57:23 am »
This vaccine was ready for clinical trials since 2006 (probably before)

http://www.cdnaids.ca/newestcanadianvaccinecandidategoing

Dr. Kang said: (in 2006)

" It is hoped that this vaccine could be available for therapeutic use within three years and for preventative use within six years"


Dr. Kang´s vaccine could be used for both thearapecutic and prohylicatic (preventive)

Even when the experimental design for the therapeutic is more simple and less time consuming.....it is seems that at the end the experiments will start with the prohylactic.

These vaccine is suported (in part) by Bill and Belinda Gates Foundation ( This foundation do not have the policts to support therapeutic vaccines).


 


Terms of Membership for these forums
 

© 2024 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.