CROI: Lipoatrophy Rare with New HIV Regimens

[Inchlingblue]

CROI: Lipoatrophy Rare with New HIV Regimens

By Ed Susman, Contributing Writer, MedPage Today

Published: February 20, 2010
Reviewed by Barry S. Zingman, MD; Professor of Clinical Medicine, Albert Einstein College of Medicine, Bronx, NY.   
 
Note that this study was published as an abstract and presented at a conference. These data and conclusions should be considered preliminary until published in a peer-reviewed journal.
SAN FRANCISCO -- Newer antiretroviral therapies appear less likely to cause wasting of fat in the limbs, which was common with long-term use of regimens devised in the late 1990s, researchers found.
In the new AIDS Clinical Trials Group study, researchers tested regimens that included the protease inhibitor atazanavir (Reyataz) boosted with ritonavir (Norvir) and another regimen based on the non-nucleoside reverse transcriptase inhibitor efavirenz (Sustiva) in patients who were also taking combinations of nucleoside reverse transcriptase inhibitors (NRTI).

The NRTI backbones consisted of tenofovir (Viread) and emtricitabine (Emtriva) in one arm and abacavir (Ziagen) and lamivudine (Epivir) in the other.

"We looked at limb fat and trunk fat and we found that all the regimens increased both limb fat and trunk fat," Grace McComsey, MD, of Case Western Reserve University in Cleveland, reported at the Conference on Retroviruses and Opportunistic Infections.

"The increase in limb fat is a good thing -- we were worried about lipoatrophy, the loss of limb fat. It was something we used to see a lot in the older regimens."

Continued . . .

LINK:

http://www.medpagetoday.com/MeetingCoverage/CROI/18592

[mecch]

"We looked at limb fat and trunk fat and we found that all the regimens increased both limb fat and trunk fat," Grace McComsey, MD, of Case Western Reserve University in Cleveland, reported at the Conference on Retroviruses and Opportunistic Infections."

Well now when my ID gets back from SF and I see him in a few weeks, he can stop telling me that its my lifestyle or diet. 

Still, I bet i can beat this bitty weight gain with diet and exercise - I was sort of afraid to try to lose weight - don't want to look "aidsy".  If my belly is the last place I'm gonna lose the weight, that means my face will get pretty damn thin.  Well its good news it wont be lipo, just skinny. 

[Miss Philicia]

Simply being thin doesn't look "aidsy" it just looks thin.  If that was the case then every 20-something hipster in skinny black jeans would have AIDS.

[Hellraiser]

Simply being thin doesn't look "aidsy" it just looks thin.  If that was the case then every 20-something hipster in skinny black jeans would have AIDS.

This is a stereotype I can get behind.

[tommy246]

"We looked at limb fat and trunk fat and we found that all the regimens increased both limb fat and trunk fat," Grace McComsey, MD, of Case Western Reserve University in Cleveland, reported at the Conference on Retroviruses and Opportunistic Infections."

Well now when my ID gets back from SF and I see him in a few weeks, he can stop telling me that its my lifestyle or diet. 

Still, I bet i can beat this bitty weight gain with diet and exercise - I was sort of afraid to try to lose weight - don't want to look "aidsy".  If my belly is the last place I'm gonna lose the weight, that means my face will get pretty damn thin.  Well its good news it wont be lipo, just skinny. 

Is it the norm for people on first line treatment to put on wieght . ive gained about 6 kilos in 3 months since starting atripla im assuming thats because im not fighting the virus 24-7