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Author Topic: least likely to cause lipo issues?  (Read 7458 times)

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Offline spoon

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least likely to cause lipo issues?
« on: July 22, 2010, 04:48:40 pm »
I recently started Atripla after having been poz for about a year. One of the reasons I chose Atripla was because I was steering away from protease inhibitors since I had read that they were linked to lipo issues. However, I was just reading that reverse transcriptase inhibitors (like the ones found in Atripla) are associated with lipodystrophy (I'll paste the quote at the end of this post).  Does anyone know which meds are the least likely to cause lipo issues in 2010? The articles I've read are at least a few years old. Also, has anyone new to treatment experienced lipodystrophy on Atripla?

I'm aware not to stress about about these issues...I'm just looking for information here. Thanks!

quote:

The current regimen for people with HIV who are beginning treatment consists of three ART drugs: two reverse transcriptase inhibitors (such as those contained in Truvada) and a third drug, usually a protease inhibitor (such as Kaletra).
However, reverse transcriptase inhibitors have been associated with lipodystrophy, a side effect in which fat gets redistributed abnormally on the body. Changes in fat distribution can lead to changes in body shape and can also cause cardiovascular disease. As a result, researchers have experimented with antiretroviral regimens, such as the Kaletra/Isentress combination, that do not contain reverse transcriptase inhibitors.
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Offline aztecan

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  • Posts: 5,530
  • 36 years positive, 64 years a pain in the butt
Re: least likely to cause lipo issues?
« Reply #1 on: July 22, 2010, 10:27:54 pm »
Emtriva and Viread, which are combined to make Truvada, which is combined with Sustiva to make Atripla, are usually referred to as being some of the least offensive nukes regarding lipoatrophy.

Neither, as far as I know, are linked to lypohypertrophy, usually the pervue of the PIs.

You are on the simplest and easiest combo to take and it has a relatively low risk of fat redistribution.

HUGS,

Mark
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"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline newbieguy

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  • Posts: 197
Re: least likely to cause lipo issues?
« Reply #2 on: July 24, 2010, 03:11:39 pm »
this is another reason I decided to stop the Rey/Truvada/Norvir combo aside from I felt it was too strong a regimen for me given my good labs plus Ive heard better about the Atripla causing wasting than the one I was on.
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