Breast Cancer breakthrough may give insights into HIV

[bimazek]

Breast Cancer breakthrough may give insights into HIV 

http://www.the-scientist.com/news/home/53062/

four genes enables tumor cells to progress  The four genes are EREG, a growth factor gene; MMP1 and MMP2, two matrix remodeling proteinases; and COX2, which produces an inflammatory protein.  group found that these genes were a part of a group of genes associated with breast cancer metastasis to the lungs

COX2, which produces an inflammatory protein

 viral proteins, such as the membrane protein gp120, induced the synthesis of both Cox-2 and IDO enzymes. The products from both these enzymes induces a state of immunological tolerance cause the CD8 cells to stop fighting the virus.... Immune tolerance suppresses the immune response against the virus

Cox-2 in HIV infections.  ibuprofen is a Cox-2 inhibitor.

Green tea and COX2 inhibitors combine to slow growth of ...
Green tea and COX-2 inhibitors combine to slow growth of prostate cancer ... Drug used to prevent HIV transmission from mother to child damages DNA ...
www.physorg.com/preview91975632.html -


Ibuprofen

Over activation of the Cox-2 enzyme results in the production of large amounts of prostaglandins. One prostaglandin, PGE2, is BOTH a major immunosuppressant AND a stimulator of cancer cell growth, metastasis and angiogenesis. There are hundreds and hundreds of scientific articles published on the role of Cox-2 prostaglandins in cancer cell development, yet oncologists never prescribe indomethacin, a powerful cox-2 inhibitor (primarily used to treat gout), to treat cancer or leukemia. Why?

The following article is a good general introduction of the role of Cox-2 enzyme activity and breast cancer. This is just one of many, many such articles.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=14993030&itool=pubmed_docsum


Any agent that increases cyclic AMP levels in lymphoid tissues blocks alpha and beta interferon synthesis. This list includes Cox-2 derived PGE2 prostaglandins, and stress hormones such as epinephrine (adrenaline) and norepinephrine.

http://www.google.com/search?hl=en&q=COX2+hiv&btnG=Google+Search







EREG             EREG

http://scholar.google.com/scholar?hl=en&lr=&q=+hiv+Growth+factors++EREG&btnG=Search

[J220]

Hey bimazek as usual, great info, but for the life of me I can't make sense of beginning or end of specific topics in the text body. Maybe it's just me, but could you orgazine your posts a bit better? Just a friendly suggestion, cause I do like reading your posts....J.