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Author Topic: Medication options after resistance  (Read 2308 times)

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Offline TabooPrincess

  • Member
  • Posts: 314
Medication options after resistance
« on: December 24, 2010, 09:29:07 am »
Does anyone know if there are any once a day meds options if someone has built up resistance to one or all of; kaletra, kivexa and viread (as a combo)?

Sorry to be vague, this is for my partner not me.  He struggled with this once a day regime (clearly as he built up resistance) and now I'm concerned that his only options will be twice a day regimes which I think he's going to find near impossible.  He's vague about what the doctors have said to him.  His Cd4 is very low, around 100 so I'm really worried for him.

Any input would be appreciated!
09/ 2008 - Seroconversion
11/2008 - Tested pos, cd4 640 vl 25400
12/2008 - cd4 794 vl 27798, 35%
03/2009 - cd4 844 vl 68846, 35%
06/2009 - cd4 476 vl 49151, 33% (pregnancy confirmed)
08/2009 - cd4 464 vl 54662, 32%
Started meds for pregnancy (Kaletra, AZT, Viread)
09/2009 - cd4 841 vl 3213, 42%
10/2009 - cd4 860 vl 1088, 41%
11/2009 - cd4 771 vl 563, 38%
12/2009 - cd4 885 vl 151 42%
Discontinued meds after baby born
02/2010 - cd4 841 vl 63781, 38%
05/2010 - cd4 1080 vl 113000, 39%
08/2010 - cd4 770 vl 109242
12/2010 - cd4 642 vl 111000, 34%
06/2011 - cd4 450 vl 222000, 33%
11/2011 - cd4 419 vl 212000, 24%
03/2012 - cd4 280 vl 118000, 26% (repeated Cd4 at 360)
05/2012 -cd4 360 vl 99,190
10/2012 Atripla, cd4 690, vl 80
12/2012 Darunavir, norvir, truvada, Cd4 680, vl u/d
07/2013 cd4 750,ud

Offline eric48

  • Standard
  • Member
  • Posts: 1,361
Re: Medication options after resistance
« Reply #1 on: December 26, 2010, 10:43:24 am »
Sorry Taboo

Sorry about saying this below.

Often on this forum I see very moving answers such as : sorry for your loss

I just hope this will not happen because of this virus.

Your (his) best choice is for a combo that will match the virus profile and resistance / history

His CD4 count is low. It is important that is he fully adherent to the combo that will be prescribed.

It is easier with once a day. Maybe for some people it is also easier to forget when it is once a day.

You seem to care about him.

I suppose you will have to nurse him into taking his med religiously.

Regardless of the number of times/day

Good luck and take care of you 2

Eric
NVP/ABC/3TC/... UD ; CD4 > 900; CD4/CD8 ~ 1.5   stock : 6 months (2013: FOTO= 5d. ON 2d. OFF ; 2014: Clin. Trial NCT02157311 = 4days ON, 3days OFF ; 2015: https://clinicaltrials.gov/ct2/show/NCT02157311 ; 2016: use of granted patent US9101633, 3 days ON, 4days OFF; 2017: added TDF, so NVP/TDF/ABC/3TC, once weekly

 


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