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Author Topic: HIV can be cured, easy  (Read 13925 times)

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Offline Poz Brit

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HIV can be cured, easy
« on: September 07, 2006, 05:04:34 am »
I was chatting on line and the conversation went to Pheromones, as the other party is a user of them and pointed out a thread in a forum for pheromones, well here is the link http://pherolibrary.com/forum/showthread.php?p=189778&posted=1#post189778 there is a bloke there trying to educate about condom use and warning of HIV and STD, and receiving flack for it, here is a Quote from the thread.
Quote
Seeing that all viral infections can be wiped out with Ozone treatment so easy and so cheap no dramas no regrets, just a fresh start, but of course the remedy is not easily accepted by the minds of some because it is so simple and so cheap, and some people think that treatment has to be expensive to work.Well for a man who is 55 and told by the doctors and specialists that i wouldnt get to 30 i really do know better, it only takes Study and APPLICATION, But some find it very comforting to live with their little very special afflictions, after all they get attention and consessions and of cource only heaps of money can make us better it has to be a lot, or even better a new great scientific discovery. OK this isnt directed at you personally Regret, just at so many who say we havent got a chance. I have seen Ozone utterley obliterate aids and other sneaky viral conditions including very serious cancers. Elements in our society do and will suppress the effacy of ozone treatment, and the pharmaceutical companys are the worst at distributing bullshit, and manufacturing scientific reasons why simple and inexpensive treatments wont work, as they will do anything to protect their form of income the parasites.

Personally I find this hard to believe that there are people out there that think this crap.
John(UK)

Offline anniebc

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Re: HIV can be cured, easy
« Reply #1 on: September 07, 2006, 06:58:19 am »
Every village has it's idiot...they're always good for a laugh.

Hugs
Jan :-*
-----------------------------------------------------------------------
Never knock on deaths door..ring the bell and run..he really hates that.

Offline Cliff

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Re: HIV can be cured, easy
« Reply #2 on: September 07, 2006, 07:26:24 am »
That's funny!  I ran across this website.  It talks about giving ozone treatments up the bum (or vagina).  They blow air up your bottom and then ask that you not release it.  Yeah right.

http://www.appliedozone.com/medical.html

I suppose people seek these treatments out of ignorance, desperation and a lack of trust (for the medical establishment).  The sad part is that there are jerks more than willing to take their money.

Offline Lisa

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Re: HIV can be cured, easy
« Reply #3 on: September 07, 2006, 07:39:18 am »
Well I'd be willing to give it a go, but admittedly would be a little miffed to find all manner of wildlife, and insects forming a conga line on my porch. :o ;D
No Fear  No Shame  No Stigma
Happiness is not getting what you want, but wanting what you have.

Offline Lisa

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Re: HIV can be cured, easy
« Reply #4 on: September 07, 2006, 07:41:35 am »
C'mon Cliffy...we are all pretty used to folk blowing smoke up our asses......... :-X
No Fear  No Shame  No Stigma
Happiness is not getting what you want, but wanting what you have.

Offline Iggy

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Re: HIV can be cured, easy
« Reply #5 on: September 07, 2006, 08:14:41 am »
.
« Last Edit: January 12, 2007, 09:36:08 pm by Iggy »

Offline Andy Velez

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Re: HIV can be cured, easy
« Reply #6 on: September 07, 2006, 08:58:30 am »
Does that mean the problems with the ozone layer would be useful for something?Just asking.
Andy Velez

Offline pozguy75

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Re: HIV can be cured, easy
« Reply #7 on: September 07, 2006, 09:26:20 am »
Smoke and mirrors...smoke and mirrors...these people are unbelievable...
Dx 2005
ATRIPLA

Offline HIVworker

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  • HIV researcher
Re: HIV can be cured, easy
« Reply #8 on: September 07, 2006, 09:30:20 am »
Andy,

Yes, it is a double-whammy. I think ozone is a potentially toxic material. I have no doubt it inactivates HIV in a test tube, but so does bleach and I'd not recommend putting that up someones exhaust pipe...

Rich
NB. Any advice about HIV is given in addition to your own medical advice and not intended to replace it. You should never make clinical decisions based on what anyone says on the internet but rather check with your ID doctor first. Discussions from the internet are just that - Discussions. They may give you food for thought, but they should not direct you to do anything but fuel discussion.

Offline carousel

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Re: HIV can be cured, easy
« Reply #9 on: September 07, 2006, 09:34:02 am »
.
« Last Edit: February 15, 2007, 12:26:40 pm by carousel »

Offline DanielMark

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Re: HIV can be cured, easy
« Reply #10 on: September 07, 2006, 10:34:43 am »
"I have seen Ozone utterley obliterate aids and other sneaky viral conditions including very serious cancers."

Proving once again that idiots are roaming the earth, and some of them have Internet access.

In a way it makes me laugh. In another way it makes me want to weep.

Daniel

MEDS: REYATAZ & KIVEXA (SINCE AUG 2008)

MAY 2000 LAB RESULTS: CD4 678
VL STILL UNDETECTABLE

DIAGNOSED IN 1988

Offline Jeff64

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Re: HIV can be cured, easy
« Reply #11 on: September 07, 2006, 10:36:45 pm »
<<That's funny!  I ran across this website.  It talks about giving ozone treatments up the bum (or vagina).  They blow air up your bottom and then ask that you not release it.  Yeah right.

http://www.appliedozone.com/medical.html

I suppose people seek these treatments out of ignorance, desperation and a lack of trust (for the medical establishment).  The sad part is that there are jerks more than willing to take their money.>>


Oh, I dont pay for those treatments, I just use the air hose at the gas station!

I really do find it hard to believe that we still have these snake-oil salesmen in the world...you would think that people would at least do a little research or speak to their own doctors prior to ungergoing a possible harmful procedure or therapy.

Guess there is a sucker born every minute!

Jeff

Offline malibueast

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Re: HIV can be cured, easy
« Reply #12 on: September 07, 2006, 11:39:56 pm »
the funny thing about HIV is that it has always been preventable and now with proper treatment and care can be contained.  the idea of this major cure has been floating around for years.  i remember when i started taking meds in 1997 that it was thought that after a couple years, the virus would simply disappear.  well that didn't happen.

Offline gvcmdny

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Re: HIV can be cured, easy
« Reply #13 on: June 27, 2007, 11:39:53 pm »
There are several methods with which a human organism fights an infectious diseases. One is a release by microphages a hydrogen peroxide, (H2O2), which is very highly toxic to bacteria, virus and fungi, second is a nitric oxide, released from endothelial cells (famous Viagra has a same effect-release of NO (nitric oxide) from endothelia cells (I am not saying that Viagra can cure an HIV infection) and another way is a release of oxygen free radicals which generates an oxydative stress. Blood cells can "survive" an oxydative stress, but bacteria, virus and fungi can not. Hydrogen peroxide releases also an anion of oxygen (same oxydative stress). you can find enormous scientific material regarding mentioned compounds in pubmed (library of medicine, national institute of health).
if somebody is interested to research a little, I can provide a scientific articles regarding studies what has been done already or in stage of development.

Offline Cerrid

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Re: HIV can be cured, easy
« Reply #14 on: June 28, 2007, 07:08:52 am »
second is a nitric oxide, released from endothelial cells (famous Viagra has a same effect-release of NO (nitric oxide) from endothelia cells

Poppers does that, too! ;D

Anyways, nobody doubts that the human body uses these highly aggressive substances to fight and destroy invaders. But it does so under extremely fine-tuned and controlled conditions. Besides, these radical substances have very short half-lives, they're inactivated within seconds. It's absolutely detrimental for your health if you suggest one should inhale or ingest ozone, NO, peroxides and stuff... it'll damage your body tissue faster than anything else, causing pulmonary diseases and a lot of other undesirable complications.

"Boredom is always counterrevolutionary. Always." (Guy Debord)

Offline emeraldize

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Re: HIV can be cured, easy
« Reply #15 on: June 28, 2007, 07:18:45 am »
if somebody is interested to research a little, I can provide a scientific articles regarding studies what has been done already or in stage of development.


Yes, please. I am always interested in the HIV research my tax dollars help to fund.  And, welcome to the site.  Thank you.   Em

Offline Basquo

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Re: HIV can be cured, easy
« Reply #16 on: June 28, 2007, 09:04:11 am »
There are several methods with which a human organism fights an infectious diseases. One is a release by microphages a hydrogen peroxide, (H2O2), which is very highly toxic to bacteria, virus and fungi, second is a nitric oxide, released from endothelial cells (famous Viagra has a same effect-release of NO (nitric oxide) from endothelia cells (I am not saying that Viagra can cure an HIV infection) and another way is a release of oxygen free radicals which generates an oxydative stress. Blood cells can "survive" an oxydative stress, but bacteria, virus and fungi can not. Hydrogen peroxide releases also an anion of oxygen (same oxydative stress). you can find enormous scientific material regarding mentioned compounds in pubmed (library of medicine, national institute of health).
if somebody is interested to research a little, I can provide a scientific articles regarding studies what has been done already or in stage of development.

Huh?

Offline Bucko

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Re: HIV can be cured, easy
« Reply #17 on: June 28, 2007, 04:32:20 pm »
<Been waiting with bated breath to add>

This is obviously what is meant by a hole in the ozone layer.

 :D
Brent
(Who has heard all those "wonder treatments" before)
Blessed with brains, talent and gorgeous tits.

Blathering on AIDSmeds since 2005, provocative from birth

Offline milker

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Re: HIV can be cured, easy
« Reply #18 on: June 28, 2007, 05:49:57 pm »
pubmed is as accurate as wikipedia. It's not because something is published in pubmed that it is accurate.

Milker.
mid-dec: stupid ass
mid-jan: seroconversion
mid-feb: poz
mar 07: cd4 432 (35%) vl 54000
may 07: cd4 399 (28%) vl 27760
jul 07: cd4 403 (26%) vl 99241
oct 07: cd4 353 (24%) vl 29993
jan 08: cd4 332 (26%) vl 33308
mar 08: cd4 392 (23%) vl 75548
jun 08: cd4 325 (27%) vl 45880
oct 08: cd4 197 (20%) vl 154000 <== aids diagnosis
nov 2 08 start Atripla
nov 30 08: cd4 478 (23%) vl 1880 !!!!!!!!!!!!!!!!!!!!!!!!!!
feb 19 09: cd4 398 (24%) vl 430 getting there!
apr 23 09: cd4 604 (29%) vl 50 woohoo :D :D
jul 30 09: cd4 512 (29%) vl undetectable :D :D
may 27 10: cd4 655 (32%) vl undetectable :D :D

Now accepting applications from blowjob ninjas™

Offline gvcmdny

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Re: HIV can be cured, easy
« Reply #19 on: June 28, 2007, 09:43:38 pm »
Thanks guys for warm welcome. I am european M.D. live in the U.S., I came on this site as my partner is interested and he recommended this website. As a research physician I am interested in new discoveries in HIV/AIDS field. I have 16 years of medical research background and the answer on the post regarding a time frame of hydrogen peroxide, oxygen free radicals are very short. It's a very complex process involving an army of small "messenger" molecules from part of defense system, including but not limited by chemokines, cytokines, tumor necrosis factor alpha, etc. Some how (Still mystery for actual medicine) how the defense mechanism is shot down. as well as content of nitric oxide in the exhaled air from hiv positive patient contains very decreased amount of NO (nitric oxide).
late scientific discoveries shows that viral genome plays very dramatic role to "turn off" a gene responsible on immune response. I am still in search of best (less hepato- and nephrotoxic) compound to eliminate a virus from the patient. I am optimist by nature (regardless my HIV status, I am negative, have been exposed in many occasions to virus, but never got it, maybe because of my CCR5/CXCR4 mutation on the surface of T cell) and I won't stop until I will not find an answer, how to kill and eliminate virus from my partner's body. Any questions will be answered based on my medical background. If I don't know an answer, I know where to look for it.
« Last Edit: June 28, 2007, 09:49:50 pm by gvcmdny »

Offline milker

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Re: HIV can be cured, easy
« Reply #20 on: June 28, 2007, 10:06:09 pm »
Haaaaaaaaaaaaa !!!

You're talking about the blood pressure and the NO being lowered in HIV+ patients. There also have been studies about PIs showing that PIs are lowering the NO and decreasing the blood pressure. So what you're saying is that there are also studies about inhaling nitric oxide that would help, since there seems to be a correlation between NO decreases and HIV, right?

As an aside, i'm curious about your CCR5/CXCR4 mutation.. but that would be for a different post!

Milker.
mid-dec: stupid ass
mid-jan: seroconversion
mid-feb: poz
mar 07: cd4 432 (35%) vl 54000
may 07: cd4 399 (28%) vl 27760
jul 07: cd4 403 (26%) vl 99241
oct 07: cd4 353 (24%) vl 29993
jan 08: cd4 332 (26%) vl 33308
mar 08: cd4 392 (23%) vl 75548
jun 08: cd4 325 (27%) vl 45880
oct 08: cd4 197 (20%) vl 154000 <== aids diagnosis
nov 2 08 start Atripla
nov 30 08: cd4 478 (23%) vl 1880 !!!!!!!!!!!!!!!!!!!!!!!!!!
feb 19 09: cd4 398 (24%) vl 430 getting there!
apr 23 09: cd4 604 (29%) vl 50 woohoo :D :D
jul 30 09: cd4 512 (29%) vl undetectable :D :D
may 27 10: cd4 655 (32%) vl undetectable :D :D

Now accepting applications from blowjob ninjas™

Offline gvcmdny

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Re: HIV can be cured, easy
« Reply #21 on: June 28, 2007, 11:08:36 pm »
you got it... :'(
« Last Edit: June 28, 2007, 11:22:39 pm by gvcmdny »

Offline gvcmdny

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Re: HIV can be cured, easy
« Reply #22 on: June 28, 2007, 11:17:08 pm »
Yes Milker, that's exactly. there is co-relation in between NO and HIV. higher VL=lower concentration of exhaled NO. and regarding sniff of NO the answer is no as NO reacts with an oxygen from air and transforms in Nitric Dioxide (NO2), I am talking NO released from endothelial cells. about my CCR5/CXCR4 mutation I have nothing to do. my parents gave me genetic "defect". during 3 years of relationship with my partner I never used a condom. because of my job I have to test myself every 3 month and I do so. anyway, I do my clinical research to determine how to make artificially chromosome to mutate. in other hand, if mosquito caring west nile virus will bite me I will have 6 hours window to make my "move". after that my immune system will collapse. so there is pro and cons in my parent's "gift".
BTW, if you are interested in ozone therapy there is an ocean of information regarding clinical studies already conducted worldwide. there is an issue of money, as everyone knows well. there is enormous amount of finances involved in HIV/AIDS matter. just for simple calculations, there are more then 40 million infected persons in the world and the pharmaceuticals are making billions. I would not go in that discussion as I can not change anything there. I would love to, but I can not, unfortunately. my advise to everyone, save yourself as you can. I don't think the cure will come from biopharmaceutical industry. there is a lot of money on the table...

Offline gvcmdny

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Re: HIV can be cured, easy
« Reply #23 on: June 28, 2007, 11:29:30 pm »
just for general information...
 
edited to remove a link to a commercial site.
« Last Edit: June 29, 2007, 05:56:41 am by Ann »

Offline Matty the Damned

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Re: HIV can be cured, easy
« Reply #24 on: June 29, 2007, 12:21:52 am »
GV,

That link really isn't "general information", it's snake oil spam.

Reported.

MtD

Offline gvcmdny

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Re: HIV can be cured, easy
« Reply #25 on: June 29, 2007, 12:30:53 am »
everyone believes what they want to believe...

Offline bimazek

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Re: HIV can be cured, easy
« Reply #26 on: June 29, 2007, 02:03:11 am »
dear dr. gvcmdny:

could you please take a look at my posts under research on here an tell me your thoughts

search on this page
useing my user name
by user:

bimazek

http://forums.poz.com/index.php?action=search

especially on key words

cd8

fas

node

LTNP


http://news.bbc.co.uk/2/hi/health/6230580.stm

some of the paradoxes of hiv one of which was just published this week, that the enigma of the slow loss of cd4 cells, if the virus was behaving as thought the scientists said the immune system would be distroyed in a few short months not 9 to 15 years.

http://news.bbc.co.uk/2/hi/health/6230580.stm

"It was thought infected cells produced more HIV particles and that this caused the body to activate more T cells which in turn were infected and killed."

it may be pd-1 on the cd8 cells this would make sense in alot of ways

basically hiv is a

CD4 cell lymph node homing signal disease, the CD4 cells are told to go back to nodes by a FasL signal and it is there that they are distroyed

i have posted this numerous times.

basically this is my theory from thousands of hours of reading

basically the hiv is very confusing to the immune system because it lives in the immune system and reproduces in the cd4 cell, this causes many issues

of course the fact that it is retrovirus is important

but lets just look at the plateau period after acute infection and before the immune system starts to really collapse, or just up to that cliff and as we start to go down the cliff

the plateau period -- basically the cd4 cells are between 800 down to 200 or so and VL can be all over map, 1000, 10k, 100k, 300k etc

during the plateau period - what is going on - the immune system is doing a fantastic job of fighting off the virus and sweeping up all the debris, (i know about the cytokines, TNF etc)  recently in this paper...

http://forums.poz.com/index.php?topic=13031.0
Breakthru Diagram shows CD8 LTNP info presented New most advanced
Diagram shows CD8 LTNP breakthru info presented New most advanced
http://bloodjournal.hematologylibrary.org/content/vol109/issue11/images/large/zh80110704370001.jpeg

this diagram shows what happens

there are two processes going on at same time

and the CD8 cells are doing alot of work,

but over time the pd-1 is activated by a protein or touching hiv or an antigen they dont know exactly

this causes at the cliff, the 200 and below the rapid falling of the immune system

they just proved that it is the % or amount of pd-1 on the cd8 that is turned on that causes the cd8 to stop working, when cd8 stops working then the collapse the immune system looses cd4 very very fast

that is why we need blood tests all the time,

since the system is a non-linear system... i studied
non-linear systems in university .... more than the sum of the parts

do a search on here for non-linear systems -- i did a post on it

anyway

that is why the problems can be so up and down one week good and one day very bad because the immune system is like one of those weird sound machines in a 50s science fiction, the one that makes all the weird sounds even though the knobs are not touched, that is an example of a non linear system that you can hear --
constant changes and variability even though the state is suppose to be level

well
so

when too many pd-1 say 50% get experessed on outside of cd8 then cd8 stops working and the immune system looses cd4s fast

why is there not too much drama during the plateau period that can last for 7-13 years

because ... well every day there is a big war going on but the immune system is great at doing its job, but it sends the soldiers back to the lymph nodes with a homing signal because the body thinks that the fight is over every day because

THE BODY HAS NO WAY OF KNOWING THAT THE VIRUS, THE INVADER IS ACTUALLY INSIDE PART OF THE IMMUNE system -- so when a immune response is done and the body gets things under control then it backs off thinking things are ok, but then more virus is produced and this is going on simultaneously and in 3D, so that in some parts of body the battles may be going better than in others...

(i posted about another theory called relativistic localized immune difficiency -- this is where say you cut off blood flow by sitting for a long period then the toxins cant be removed fast enough, the hiv in a small area get reved up and then the immune system is really low and weak in one tissue area, and say that that happens to be near the nerve center where a herpes is then you get shingles-- this part  is my theory -- i havent searched to see if any of it is proven)

anyway

so the homing signal and the fasL - i posted some great stuff about why anabolic steriods help people for a short while and it has to do with fas or fasL and homing signals  -- posted on here

check out my posts in research on here



« Last Edit: June 29, 2007, 02:07:02 am by bimazek »

Offline Cerrid

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  • only as good as your last haircut
Re: HIV can be cured, easy
« Reply #27 on: June 29, 2007, 03:09:29 am »
I am still in search of best (less hepato- and nephrotoxic) compound to eliminate a virus from the patient.

It's just been done for the first time in history, using tailor-designed molecular scissors called recombinases. So far not in a patient, but in a single cell. However, it's a start. Have a look at the new edition of Science:

http://www.sciencemag.org/cgi/content/abstract/316/5833/1912
"Boredom is always counterrevolutionary. Always." (Guy Debord)

Offline RapidRod

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Re: HIV can be cured, easy
« Reply #28 on: June 29, 2007, 04:32:10 am »
In the past 30 years I have seen a lot of promising results that turned to failure and the waste basket.

Offline Ann

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Re: HIV can be cured, easy
« Reply #29 on: June 29, 2007, 06:01:11 am »
gvc,

I removed the link you provided a few posts up because it went to a page that linked to a commercial site. We don't allow that here - especially when the site is one that hawks an unproven therapy.

Please re-read the Terms of Membership which you agreed to when you became a member, particularly the following paragraph:

Quote
Messages posted to the AIDSmeds.com Forums must not contain marketing information, either from a pharmaceutical company; a healthcare provider (i.e., seeking to provide services to the HIV community); or the manufacturer or distributor of a complementary, alternative, herbal, traditional, and/or surgical treatment approach.

I'd also like to ask you to read the Welcome Thread and take note of our forum posting guidelines.

Thank you for your cooperation.

Ann
Condoms are a girl's best friend

Condom and Lube Info  

"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline gvcmdny

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Re: HIV can be cured, easy
« Reply #30 on: June 29, 2007, 09:04:56 am »
Dear Ann,

I understand a policy of this website. I am not promoting anything to anyone. the most websites contain a commercial links. I do understand that. next time probably I will just cut and paste the valuable information without linking to commercial propaganda. I will keep in mind your suggestions. Thank you, dear.

Offline Ann

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Re: HIV can be cured, easy
« Reply #31 on: June 29, 2007, 09:14:42 am »
gvc,

If you have links to articles published in peer-review, scientific/medical journals, those would be fine. Just don't post information as published on commercial sites.

You can find our guidelines on posting articles here

Again, thank you for your cooperation.

Ann
Condoms are a girl's best friend

Condom and Lube Info  

"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline gvcmdny

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Re: HIV can be cured, easy
« Reply #32 on: June 29, 2007, 12:20:27 pm »
Guys, I perfectly understand that sometimes there can be very frustrating when some promising information fails and crushes the dreams, but it's like in life, when if you are falling in the dirt, you won't stay there like an animal do, but you just have to get up, shake the dirt from you clothes and keep walking. The bitterness will not give us any progress in your life, one brain is good but when more brains are in constructive conversation, there will be always light in the end of the road. I will try to give objective information based not only on my allopathic medical background but also holistic approaches on HIV/AIDS matters.

Offline RapidRod

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Re: HIV can be cured, easy
« Reply #33 on: June 29, 2007, 02:26:37 pm »
Quote
I will try to give objective information based not only on my allopathic medical background but also holistic approaches on HIV/AIDS matters.

Don't waste your time and energy posting it here. It's not needed, helpful or proven medicine. This site does not take kindly to quackery.

Offline gvcmdny

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Re: HIV can be cured, easy
« Reply #34 on: June 29, 2007, 02:39:18 pm »
Rapidwhatever, I am not in this site only for you, so keep your opinion for you, I am not interested and I won't enter in arguments with you. have a nice life.

Offline RapidRod

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Re: HIV can be cured, easy
« Reply #35 on: June 29, 2007, 02:49:38 pm »
I try to always have a nice day. Thank you very much.

Offline Ann

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Re: HIV can be cured, easy
« Reply #36 on: June 29, 2007, 02:51:29 pm »
gvc,

I'm not frustrated and I'm not bitter. But I AM telling you to not post "information" or psuedo-science that you've lifted from commercial sites, along with not linking to such sites. We like to go with peer-reviewed science here.

Ann

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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline gvcmdny

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Re: HIV can be cured, easy
« Reply #37 on: June 29, 2007, 02:57:48 pm »
Cerrid I checked the website you provided me. I went into Nat. Library of medicine and I found this very interesting article. The research has been done in Japan. Here is the text of this study:

Department of Molecular Genetics, Nagoya City University Medical School, Japan.

Gene expression of human immunodeficiency virus (HIV) depends on a host cellular transcription factors including nuclear factor-kappaB (NF-kappaB). The involvement of reactive oxygen intermediates (ROI) has been implicated as intracellular messengers in the inducible activation of NF-kappaB. In this study, we compared the efficacy of two antioxidants, alpha-lipoic acid (LA) and N-acetylcysteine (NAC), which are widely recognized NF-kappaB inhibitors. Here, we demonstrate that LA has a more potent activity in inhibiting NF-KappaB-mediated gene expression in THP-1 cells that have been stably transfected with a plasmid bearing a hygromycin B resistance gene under the control of HIV-1 long terminal repeat (LTR) promoter. The spontaneous activation of NF-kappaB in this cell culture system leads to expression of the hygromycin phosphotransferase gene hence rendering the cells resistance to hygromycin B. In this study, the effect of the test compounds against transcriptional activity of HIV-1 LTR was evaluated based on the degree of cellular toxicity due to the inhibitory activity on the expression of hygromycin B resistance gene in the presence of hygromycin B. We also found that 0.2 mM LA could cause 40% reduction in the HIV-1 expression from the TNF-alpha-stimulated OM 10.1, a cell line latently infected with HIV-1. On the other hand, 10 mM NAC was required to elicit the same effect. Furthermore, the initiation of HIV-1 induction by TNF-alpha was completely abolished by 1 mM LA. These findings confirm the involvement of ROI in NF-kappaB-mediated HIV gene expression as well as the efficacy of LA as a therapeutic regimen for HIV infection and acquired immunodeficiency syndrome (AIDS). Moreover, this study validates the applicability of our present assay system which we primarily designed for the screening of candidate drugs against HIV-1 gene expression.

Source: PMID: 8925935 [PubMed - indexed for MEDLINE]

MY COMMENTS: As I previously stated, my major goal is elimination completely viral mRNA from the system. Nothing personal but I realized that today's pharmaceutical research is trying to put "patches" on treatment options. unfortunately, today's doctors are treating symptoms, not disease per si.
My research interest from one hand is focused to neutralize virus, by innate immunity or some external compounds and in other hand I am focused also CCR5/CXCR4 delta32 mutation. As I mentioned previously I have that mutation, because of that I never get infected regardless my sexual positions. I am working on the issue to "provoke" this change in the chromosomal level, deleting the allele of delta32. My partner is positive and I have everything I need, his normal chromosome and my mutated chromosome. There is a theory that because of black plague, surviving persons have been developed this "surviving" alterations on genome level.

Offline gvcmdny

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Re: HIV can be cured, easy
« Reply #38 on: June 29, 2007, 03:01:31 pm »
Ann, I did not say bitter about you. I said sometimes frustration makes us bitter, it's normal. I am trying to fight that in myself. If I somehow upset you, my apologies, I was not saying that about you and not about anyone in particular. it was just an expression.

Offline Ann

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Re: HIV can be cured, easy
« Reply #39 on: June 29, 2007, 03:03:59 pm »
gvc,

I wasn't offended, I just wanted to make certain we were on the same page as regards the quality and source of information you present as fact in this forum.

;)

Ann
Condoms are a girl's best friend

Condom and Lube Info  

"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline thunter34

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Re: HIV can be cured, easy
« Reply #40 on: June 29, 2007, 03:05:33 pm »
This thread just makes me think of Naomi Campbell on Ab Fab:

"I plug my hole with Ozone."
AIDS isn't for sissies.

Offline RapidRod

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Re: HIV can be cured, easy
« Reply #41 on: June 29, 2007, 03:05:49 pm »
Why can't this be placed in Research News forum, instead of this forum?

Offline gvcmdny

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Re: HIV can be cured, easy
« Reply #42 on: June 29, 2007, 03:13:02 pm »
RapidRod, I am new in this site and I didn't know that there is a research page here. any suggestions how to put there?

Actually there was an interesting interview in PBS station. I just copy and pasting for review.
It's an interview with Dr. Stephen O'Brien, M.D.

Interview

You may possess a genetic mutation. Most people would probably be aghast to learn that one of their genes is malformed. But before you start asking, "What does that mean? Will it make me sick someday? Will I pass it on to my children?" bear in mind that a mutation of the CCR5 gene -- called "delta 32" in its mutated form -- has no adverse effect on humans. In fact, possessing delta 32 could save your life, and the lives of your children.

"It's highly unusual," says Dr. Stephen J. O'Brien of the National Institutes of Health in Washington D.C. "Most genes, if you knock them out, cause serious diseases like cystic fibrosis or sickle cell anemia or diabetes. But CCR5-delta32 is rather innocuous to its carriers. The reason seems to be that the normal function of CCR5 is redundant in our genes; that several other genes can perform the same function."

"The non-mutated form is what's called a chemokine receptor," he says. Chemokines are protein distress calls released by an injured region of your body. "The normal function of the CCR5 gene is to act as a retriever of the chemokine distress signal from these bruises, which will then be alleviated by the chemokines."

This may not sound exciting, but delta 32 is a powerful mistake. HIV, the virus that causes AIDS, attacks the human immune system, infecting the white blood cells sent to destroy it. The delta 32 mutation, however, effectively blocks the crucial gateway into human cells the virus needs. In the case of Steve Crohn, whose partner was the fifth person to die from AIDS, possessing the CCR5 mutation has prevented him from contracting the virus.

O'Brien explains further, "In order to have total resistance to HIV, you have to carry two doses of the mutated gene -- one from each parent. If you get only one dose, you will not be resistant to infection. However, you may be able to delay the onset of HIV once you become infected. That's because, in patients with one copy of the mutation, the amount of 'portals' or 'doorways' that HIV can use is reduced by about 50 percent. That slows down virus replication, which is the most important factor in AIDS progression."

O'Brien's work on AIDS led him to another disease that delta 32 could prevent, the plague. "They both, upon entering the body, infect the macrophages, which are the first line of defense against bacterial infections," he says. "Over the course of evolution, many bugs and pathogens have become extinct because the body learned how to defend itself against them. So the ones that are around today, like HIV and the plague, are pretty savvy -- HIV, for example, specifically attacks and kills the very cells that are designed to kill it. Both these pathogens have developed very clever ways around our immunological defenses."

The results of the Eyam study suggest that delta 32 may have helped save Europe from the bubonic plague pandemic. It seems logical, then, that this could be confirmed by an experiment in which the plague bacterium is injected into the cells of someone possessing the delta 32 mutation. "We have attempted to design experiments that allow us to expose the plague to the lymphocytes of different people, including Steve Crohn," O'Brien says. "But so far we haven't been able to design that kind of experiment ... to do that experiment, you would need to isolate that particular kind of cell. You would need to isolate the exact strain of the plague, and you would need to expose them together."

Nevertheless, delta 32 seems to be a formidable defense the human body has developed in response to ages of pathogenic exposure. And though we may just be getting acquainted with it, delta 32 has been protecting humans for ages. O'Brien suspects the mutation has been around since long before the Black Death. "There have been human remains dug up from graves in Scandinavia -- bodies 3,000 and 4,000 years old -- in which they actually found the mutation, through DNA typing. So there are all kinds of pieces in this puzzle that are coming together."

Source: Public Broadcasting Station, keyword: Case File: Mystery of the Black Death.

Offline RapidRod

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Re: HIV can be cured, easy
« Reply #43 on: June 29, 2007, 03:17:35 pm »
Same as you do here. Go to content on the left hand side of the screen and click on Research News.

Offline gvcmdny

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Re: HIV can be cured, easy
« Reply #44 on: June 29, 2007, 03:22:53 pm »
Thank you.

BTW, JUST GOT AN UPDATES FROM MY ACCOUNT IN NIH:

http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1630600&blobtype=pdf
« Last Edit: June 30, 2007, 02:42:01 pm by gvcmdny »

 


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