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Author Topic: Question on meds?? (NRTIs+Entry/Fusion Inhibitors)  (Read 2667 times)

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Offline audioholic

  • Member
  • Posts: 29
Question on meds?? (NRTIs+Entry/Fusion Inhibitors)
« on: April 14, 2008, 11:25:55 pm »
I recently entered a trial for a new version of viramune coupled with truvada. . . it has been going well, no side effects that i can really notice from the pills. A little lazier but not much.

my question is, ive read a lot about entry and fusion inhibitors. I would say they could or would be like the "front line" against the virus from getting my good cd4 cells. right? I have pretty good insurance and am getting the study drugs for free. If I could improve my cd4 numbers by adding another pill or treatment I would probly do it. So should i look at combining the 2 therapies?
Logged
4/07-  vl:28,918  cd4:418
7/07-  vl:38,710 cd4:354
10/07-  vl:21,320 cd4:278
baseline started meds 1/08 vl:25,589 cd4:247
2/08 vl:410 cd4:320
2/08 vl:380  cd4:374
3/08 vl:310  cd4:419   23%
3/08 vl:240  cd4:384   27%
4/08 vl:119  cd4:383   23%

Offline audioholic

  • Member
  • Posts: 29
Re: Question on meds?? (NRTIs+Entry/Fusion Inhibitors)
« Reply #1 on: April 15, 2008, 09:10:58 am »
any kind of insight would be great. . 
Logged
4/07-  vl:28,918  cd4:418
7/07-  vl:38,710 cd4:354
10/07-  vl:21,320 cd4:278
baseline started meds 1/08 vl:25,589 cd4:247
2/08 vl:410 cd4:320
2/08 vl:380  cd4:374
3/08 vl:310  cd4:419   23%
3/08 vl:240  cd4:384   27%
4/08 vl:119  cd4:383   23%

Offline bmancanfly

  • Member
  • Posts: 786
  • Medicare For All !
Re: Question on meds?? (NRTIs+Entry/Fusion Inhibitors)
« Reply #2 on: April 15, 2008, 09:26:11 am »
Hi,
Sorry I don't have an answer to your question. 
But I was wondering about the study you're in.  Is it once a day?  And one pill?
Thanks
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"The trouble with the world is that the stupid are cocksure and the intelligent are full of doubt."

 Bertrand Russell

Offline trellium

  • Member
  • Posts: 95
  • stArk raving Borg
Re: Question on meds?? (NRTIs+Entry/Fusion Inhibitors)
« Reply #3 on: April 15, 2008, 10:33:04 am »
Adding additional meds to your current working combo is an overkill and not going to improve your CD4 count.  The antiviral drugs only suppress viral replication,  how soon/fast your CD4 recovers depends on your own genes and body.

If you are in the VERxVE study, look at exclusion criteria # 9, 10 & 11.

VERxVE Study on Efficacy and Safety of Nevirapine XR in Comparison to Nevirapine IR With Truvada in Naive HIV+ Patients
http://clinicaltrials.gov/ct2/show/NCT00561925?term=viramune&cond=hiv&phase=23&rank=10

EXCLUSION CRITERIA:

9. Patients who are receiving other concomitant treatments which are not permitted, as described in the prescribing information

10. Use of investigational medications (any experimental agent other than the study regimen) within 30 days before study entry or during the trial

11. Use of immunomodulatory drugs within 30 days before study entry or during the trial (e.g., interferon, cyclosporin, hydroxyurea, interleukin 2)
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Offline audioholic

  • Member
  • Posts: 29
Re: Question on meds?? (NRTIs+Entry/Fusion Inhibitors)
« Reply #4 on: April 15, 2008, 04:15:47 pm »
not sure which study im in. . yea its for the once a day viramune. . . . its some BI trial. . . .
kinda wish i had waited till the new viciviroc test. . .

i wanna prtoect my healthy cd4 cells before HIV can even touch them thus as my body slowly builds more no more will be consumed by HIV. . . am i odd or completely wrong for tinking this will happen with entry inhibitors???
Logged
4/07-  vl:28,918  cd4:418
7/07-  vl:38,710 cd4:354
10/07-  vl:21,320 cd4:278
baseline started meds 1/08 vl:25,589 cd4:247
2/08 vl:410 cd4:320
2/08 vl:380  cd4:374
3/08 vl:310  cd4:419   23%
3/08 vl:240  cd4:384   27%
4/08 vl:119  cd4:383   23%

Offline NLEWLAD

  • Member
  • Posts: 230
  • Anything is possible, ANYTHING
Re: Question on meds?? (NRTIs+Entry/Fusion Inhibitors)
« Reply #5 on: April 15, 2008, 04:52:24 pm »
i dont think i know anything about trials

but if you take another med, along with your trial drugs,  wont you interfear with the results?
Logged
Simon - Location Manchester England
Negative test 10/11/07
Tested poz 28/12/07
Confirmed WB 07/01/08
Sero-converted Late December 07

Date        CD4            %              VL

7/01/08   1273 :)      N/A       100,232
24/01/08   755 :(      42%         4,010
13/2/08     922 :)      45%       78,234
09/04/08   652 :(      38%       36,604
05/05/08   936 :)      39%       38,952
07/07/08   844 :)      34%       24,000
12/11/08   753 :(      31%       45,600
no meds yet:)
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