Shingles Vaccine and Anal Warts Vaccine are in trials and may be approved

[bimazek]

Shingles Vaccine and Anal Warts Vaccine are in trials and may be approved

These are two diseases which are very common in hiv poz guys even on haart

and Shingles for example is horribly painful   Shingles= old chicken pox virus popping up again can cause blindness and other terrible complications

Anal Warts = HPV ... think texas with the vaccine of women for cervical cancer
get this vaccine to avoid cancer in anus

get these vaccines when and if they are approved

if you

every had chicken pox  -- you did

and

if you even had passive anal sex

[trellium]

hiya

You can ask your doc about getting Gardasil (HPV vaccine) for off-label use since it is not yet clear whether the vaccine is as effective for men as it is for women. (some risks, expensive too)

Are you referring to Zostavax (Shingles vaccine)?
It is actually a boosted dose (14 times more potent) of the Varivax (Merck's chickenpox vaccine) currently given to children and has already been approved by the FDA in 2006.

It is a live vaccine and should be avoided by all pozzies.

http://www.fda.gov/Cber/products/zosmer052506qa.htm
(from Q&A # 8  )

Who should not be immunized with Zostavax?

People who are allergic to neomycin, or any component of the vaccine should not receive Zostavax. Zostavax is a live vaccine and should not be given to individuals who have a weakened immune system caused by treatments that they are taking such as radiation, a class of drugs called corticosteroids, or due to conditions such as AIDS, cancer of the lymph, bone or blood.

In addition, Zostavax should not be used by women who are or may be pregnant.

Zostavax should not be used in children and it is not a substitute for Varivax, the vaccine to prevent chicken pox.

In addition, people who are in close contact with pregnant women who have not had chickenpox should talk to their healthcare provider to decide if using Zostavax is right for them.

[risred1]

Some Vaccines or Anti Viral Drugs such Valtrex do come with warnings about those with immune dieseases such as AIDS.

However, HIV impacted folks may still be able to be vaccinated and take Valtrex if your system is still above, "severely impacted", as stated in the Valtrex documentation.

Absolutely work with your HIV specialist, not your general practitioner, unless your GP is really up on HIV.

There is also some research going on about how these anti retroviral vaccines and drugs may infact help the body fight against HIV. I still can't find much information on this though.

 

[northernguy]

But Gardasil isn't a therapeutic vaccine is it?  So for those of us who already have HPV it won't do any good.

[hahaha]

Since my CD4 is above 400, My doc suggest me to have HPV vaccine.  He told me that actually the vaccine do, in a way, suppress HIV as well, and it "might" boost the other therapeutic vaccine in the future. 

Maybe we shall all consult with our docs to see their point of view and exchange the opinion here.

[NYCguy]

I don't know anything about the shingles vaccine, although it would seem that if tcell counts were normal it would be ok (however, absolutely check with hiv doc) but I have asked my doc about Guardasil and he gave me a script for it.  It costs about $170 but haven't bought it yet - my brother's ID doc (he's not poz, just gay and up on medical stuff) told him that it might be good to wait a while while they test it in men. 

Also, it is not a theraputic vaccine so it won't help if you already have hpv, however, my doc said it won't hurt you either.  It's still not clear to me if/how you can test for hpv.  Also, there are a number of different strains, so it's possible to have one strain and still benefit from Guardiasil if you don't have one of the four strains (the most cancer causing ones) that it protects against.

I did hear something about how it might have some theraputic effect for hiv...any more info on that appreciated.  I always worry about negative interations with potential future drugs or vaccines...

[Miss Philicia]

You test for HPV by getting an anal pap smear, or at least that is the first step.  80% of HIV positive gay men already have HPV it is estimated.

[dixieman]

When their available... I'll be first inline... never had hpv... and I had the pap smear to check for anal cancer..luckily I came back ok... but, who knows what may change in the future...  I have had shingles... 3 times at stressful moments in life... shingles are no fun...

[bimazek]

there are phase trials of Therapeutic HPV vaccines  ... that is why i posted,... even if you have the virus you can get vaccine soon... i hope for approval

In addition to preventive vaccines, such as Gardasil and Cervarix, laboratory research and several human clinical trials are focused on the development of therapeutic HPV vaccines. In general these vaccines focus on the main HPV oncogenes, E6 and E7. Since expression of E6 and E7 is required for promoting the growth of cervical cancer cells (and cells within warts), it is hoped that immune responses against the two oncogenes might eradicate established tumors.[15]
t
http://en.wikipedia.org/wiki/HPV_vaccine

i think it is Authorised Medicines for Human Use - Gardasil
Therapeutic Indication. Gardasil is a vaccine for the prevention of high-grade cervical dysplasia (CIN 2/3), cervical carcinoma, high-grade vulvar ...
www.emea.europa.eu/humandocs/Humans/EPAR/gardasil/gardasil.htm
Roche enters therapeutic vaccines market - MarketWatch


Transgene's lead product, a therapeutic vaccine candidate codenamed TG 4001, differs from Gardasil - a new vaccine made by Sanofi SA (SNY : ...
www.marketwatch.com/.../story.aspx?guid=%7BB7DB4314-C935-4828-9479-CCE819A31EB8%7D

World market for cancer vaccines 2007-2012
Revenue forecasts for Gardasil and Cervarix 2007-2012; Table 4.1. Therapeutic cancer vaccines with licenses or predicted to obtain them within the forecast ...
www.leaddiscovery.co.uk/reports/World_market_for_cancer_vaccines.html - 44k - Cached - Similar pages
Pharm Aid: Dendreon
Well, cancer vaccines are back, driven partly, by approval of Merck’s Gardasil. Therapeutic cancer vaccines are making news again. An FDA advisory committee ...
pharm-aid.blogspot.com/search/label/Dendreon


Human Papillomavirus Vaccines: Q & A - National Cancer Institute
NCI is also collaborating with other researchers on therapeutic HPV vaccines that would prevent the development of cancer among women previously exposed to ...
www.cancer.gov/cancertopics/factsheet/risk/HPV-vaccine - 54k - Cached - Similar pages
Aidsmap | An HPV vaccine - what it might really mean
Still, therapeutic HPV vaccines are also being developed to treat established ... If these therapeutic HPV vaccines prove as successful in patients as they ...
www.aidsmap.com/en/news/3429199D-5FE5-4795-B0E6-CD957617C160.asp - 30k - Cached - Similar pages

Biotechnology firms, pharmaceutical companies, and academic researchers are
working to develop vaccines against the types of human papillomavirus (HPV) that
cause most, if not all, cases of cervical cancer. Some are designing prophylactic
vaccines to prevent initial infections with HPV; if successful, these vaccines
ultimately could eliminate the public health problem of cervical cancer. Others are
focusing on therapeutic vaccines to control the progress of established disease or
prevent its recurrence in women who already have cervical dysplasia or cancer.
Vaccine developers face many technical challenges, in part because the HPV virus
itself has evolved various strategies for evading the immune response

Therapeutic HPV vaccines must prompt cell-
mediated immunity in order to be effective, since antibodies cannot reach and
eliminate the virus once it has been incorporated into host cells.


Randomized, double-blind, placebo-controlled Phase IIb trials are
currently taking place in multiple sites in Europe, Canada, Scandinavia, Australia, and
New Zealand.
34
These will assess wart recurrence rates and rates of disease
regression following vaccination.
Building on the success of its peptide vaccine against genital warts, Cantab has begun
developing a similar fusion protein vaccine to treat cervical dysplasia. By treating
early-stage cervical disease, scientists hope to reduce treatment costs and patient
trauma. This vaccine called TA-CIN uses a novel adjuvant (NAX-57) developed by
NovaVax Inc. (Columbia, MD, USA).


A major breakthrough in HPV vaccine research came with the discov-
ery that the capsid proteins L1 and L2 (or L1 alone) self-assemble into
virus-like particles (VLPs) when expressed in cells. VLPs closely
resemble native HPV particles and include the conformational epitopes
that induce virus-neutralizing antibodies. Therefore, the immune system
perceivesb VLPs as infectious viruses and responds accordingly

able 2. Therapeutic HPV Vaccines Under Development*
*Note: While efforts were made to be comprehensive, this is not a com

http://209.85.165.104/search?q=cache:GrODQKx0Pq0J:www.path.org/files/jsrp13710.pdf+%22therapeutic+HPV+vaccines%22&hl=en&ct=clnk&cd=1&gl=us

Table 2. Therapeutic HPV Vaccines Under Development*
*Note: While efforts were made to be comprehensive, this is not a complete list.